Patents by Inventor Lawrence E. Brieaddy

Lawrence E. Brieaddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KAPPA OPIOID RECEPTOR LIGANDS
    Publication number: 20120178781
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: February 29, 2012
    Publication date: July 12, 2012
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank Ivy CARROLL, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Kappa opioid receptor ligands
    Patent number: 8173678
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: May 8, 2012
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • KAPPA OPIOID RECEPTOR LIGANDS
    Publication number: 20110065743
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: October 25, 2010
    Publication date: March 17, 2011
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy CARROLL, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Kappa opioid receptor ligands
    Patent number: 7872023
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: January 18, 2011
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Therapeutic uses of a diphenylsulfide compound to treat depression and effect serotonin uptake
    Patent number: 5216028
    Abstract: A halogen-substituted diphenylsufide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: June 1, 1993
    Assignee: Burroughs Wellcome Co.
    Inventors: Nariman B. Mehta, Lawrence E. Brieaddy
  • Medical uses of halogen substituted diphenylsulfides
    Patent number: 5104897
    Abstract: A class of halogen-substituted diphenylsulfide compounds are disclosed which produce a large selective inhibition of serotonin uptake in brain. Such compounds are useful in the treatment of depression, anxiety, obsessive compulsive disorders and substance abuse disorders such as alcoholism.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: April 14, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Lawrence E. Brieaddy, Claudia E. B. Hollingsworth, Barrett R. Cooper
  • Diphenylsulfide compound and use
    Patent number: 5095039
    Abstract: A halogen-substituted diphenylsulfide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: March 10, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Nariman B. Mehta, Lawrence E. Brieaddy
  • Sulfide compounds and methods and compositions for treating depression
    Patent number: 4123555
    Abstract: Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, or R and R.sup.1 taken together are (CH.sub.2).sub.X where X is 4 or 5, or NRR.sup.1 is ##STR2## where Y is 3 or 4 and R.sup.3 is hydrogen or lower alkyl, or NRR.sup.1 is ##STR3## where R.sup.2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.
    Type: Grant
    Filed: November 12, 1976
    Date of Patent: October 31, 1978
    Assignee: Burroughs Wellcome Co.
    Inventors: Nariman B. Mehta, Lawrence E. Brieaddy