Patents by Inventor Lawrence E. Samelson

Lawrence E. Samelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LAT adapter molecule for enhanced T-cell signaling and method of use
    Patent number: 9649339
    Abstract: LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that result in an increase in stability of LAT in stimulated and unstimulated cells, and enhanced signaling through the TCR. The invention further provides use for a LAT protein including mutations at ubiquitylation sites for therapeutic and laboratory methods.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: May 16, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Lawrence E. Samelson, Lakshmi Balagopalan
  • LAT ADAPTER MOLECULE FOR ENHANCED T-CELL SIGNALING AND METHOD OF USE
    Publication number: 20150202230
    Abstract: LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that result in an increase in stability of LAT in stimulated and unstimulated cells, and enhanced signaling through the TCR. The invention further provides use for a LAT protein including mutations at ubiquitylation sites for therapeutic and laboratory methods.
    Type: Application
    Filed: July 11, 2014
    Publication date: July 23, 2015
    Inventors: Lawrence E. Samelson, Lakshmi Balagopalan
  • LAT adapter molecule for enhanced T-cell signaling and method of use
    Patent number: 8779095
    Abstract: LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that result in an increase in stability of LAT in stimulated and unstimulated cells, and enhanced signaling through the TCR. The invention further provides use for a LAT protein including mutations at ubiquitylation sites for therapeutic and laboratory methods.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: July 15, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Lawrence E. Samelson, Lakshmi Balagopalan
  • LAT ADAPTER MOLECULE FOR ENHANCED T-CELL SIGNALING AND METHOD OF USE
    Publication number: 20120114700
    Abstract: LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that result in an increase in stability of LAT in stimulated and unstimulated cells, and enhanced signaling through the TCR. The invention further provides use for a LAT protein including mutations at ubiquitylation sites for therapeutic and laboratory methods.
    Type: Application
    Filed: April 30, 2010
    Publication date: May 10, 2012
    Applicant: Government of the United States of America, as Rep by the Secretary, Department of Health and
    Inventors: Lawrence E. Samelson, Lakshmi Balagopalan
  • Protein tyrosine kinase substrate LAT and its use in the identification of (ANT) agonists of the kinase
    Patent number: 8114975
    Abstract: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: February 14, 2012
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Lawrence E. Samelson, Weiguo Zhang
  • Protein tyrosine kinase substrate LAT and its use in the indentification of (ant)agonists of the kinase
    Patent number: 7118889
    Abstract: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: October 10, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence E. Samelson, Weiguo Zhang