Abstract: Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: A system including a fabric manager, a memory mapper, and a switch is described. The memory mapper receives and stores mapping information from the fabric manager that maps memory locations in a plurality of hosts to corresponding memory locations in a plurality of physical devices. The switch receives at least a portion of the mapping information from the memory mapper, receives a request from a host, and accesses memory that is identified by the request on a physical device of the plurality of physical devices.

Abstract: A system and method of generating a plurality of actionable insights is disclosed herein. A computing system retrieves data corresponding to a work procedure. Each work procedure includes a plurality of steps. The computing system generates a predictive model for each actionable insight using a plurality of machine learning models by generating an input training based on the retrieved work procedure data and learning, by the plurality machine learning models, a metric corresponding to each actionable insight based on each respective input training set. The input data set for each actionable insight includes actionable insight specific information. The computing system receives a request to generate a plurality of actionable insights for a current work procedure. The computing system generates, via the predictive models, a plurality of metrics for a plurality of actionable insights based on data corresponding to the current work procedure.

Abstract: A system and method of generating a plurality of actionable insights is disclosed herein. A computing system retrieves data corresponding to a work procedure. Each work procedure includes a plurality of steps. The computing system generates a predictive model for each actionable insight using a plurality of machine learning models by generating an input training based on the retrieved work procedure data and learning, by the plurality machine learning models, a metric corresponding to each actionable insight based on each respective input training set. The input data set for each actionable insight includes actionable insight specific information. The computing system receives a request to generate a plurality of actionable insights for a current work procedure. The computing system generates, via the predictive models, a plurality of metrics for a plurality of actionable insights based on data corresponding to the current work procedure.

Abstract: A non-transitory computer-readable storage medium storing one or more programs, the one or more programs comprising instructions, which when executed by an electronic system with a display, cause the electronic system to display a human-centric process (HCP) authoring application window configured to allow an author to create one or more tasks for the human¬centric process, wherein HCP authoring application window displays one or more task cards, wherein at least one of the task cards includes HCP task characteristics data input fields, receive HCP task characteristics entered into the HCP task characteristics data input field of the task card by the author, determine whether the HCP task characteristics meets task authoring criteria, wherein the task authoring criteria is based on task status data and/or prior author process modification data.

Abstract: A system and method of generating a plurality of actionable insights is disclosed herein. A computing system retrieves data corresponding to a work procedure. Each work procedure includes a plurality of steps. The computing system generates a predictive model for each actionable insight using a plurality of machine learning models by generating an input training based on the retrieved work procedure data and learning, by the plurality machine learning models, a metric corresponding to each actionable insight based on each respective input training set. The input data set for each actionable insight includes actionable insight specific information. The computing system receives a request to generate a plurality of actionable insights for a current work procedure. The computing system generates, via the predictive models, a plurality of metrics for a plurality of actionable insights based on data corresponding to the current work procedure.

Abstract: Methods and systems herein employ graphical elements as a coding basis within a development platform to develop Web applications that access and aggregate real-time data of connected devices. The development platform includes testing and development functions to simplify the development of mashup web applications. In one aspect, the platform causes updates of the client-side applications, and the real-time data to be received at each test device with a save action of the development workspace. In another aspect, the platform inserts code to enable caching operations at the client-side applications, based on associative linking of the graphical objects during development. In another aspect, the platform employs multiple-level hierarchical real-time data to enable the client-side applications to maintain client-side cursors of the last presentation state of the data upon an update of the applications.

Abstract: Methods and systems herein employ graphical elements as a coding basis within a development platform to develop Web applications that access and aggregate real-time data of connected devices. The development platform includes testing and development functions to simplify the development of mashup web applications. In one aspect, the platform causes updates of the client-side applications, and the real-time data to be received at each test device with a save action of the development workspace. In another aspect, the platform inserts code to enable caching operations at the client-side applications, based on associative linking of the graphical objects during development. In another aspect, the platform employs multiple-level hierarchical real-time data to enable the client-side applications to maintain client-side cursors of the last presentation state of the data upon an update of the applications.

Abstract: A system and method for developing real-time web-service objects. The method includes providing a client-side application running on a connected device. The client-side application executes Webpage definition files having a composite Web-service objects, including a first and second composite Web-service objects where each of the object has been associatively linked to a data service from a data source. The method includes receiving, during runtime of the client-side application, a first updated data content from the data source. The method includes caching the first updated data content in memory and, upon receiving a second updated data content, retrieving the first updated data content from memory and updating the composite Web-service objects of the Webpage definition files using the first and second update data contents.

Abstract: The present disclosure provides a system and method for managing data using semantic tags. The method may include providing a data model corresponding to a first set of tangible objects where the data model includes a first template class having both properties describing the set of tangible object and a set of semantic tags corresponding to the properties. The method may include receiving a class definition for a second template class for a second set of tangible objects where the second template class inherits, by the class definition, the properties and the sematic tags for the second set of tangible objects.

Abstract: The present disclosure provides a system and method for managing data using semantic tags. The method may include providing a data model corresponding to a first set of tangible objects where the data model includes a first template class having both properties describing the set of tangible object and a set of semantic tags corresponding to the properties. The method may include receiving a class definition for a second template class for a second set of tangible objects where the second template class inherits, by the class definition, the properties and the semantic tags for the second set of tangible objects.

Abstract: A system and method of using multi-level hierarchical data in displaying real-time Web-service objects is provided. The method includes providing, at a client-side application at a computing device, a graphical user interface having one or more rendering widgets and an input widget having one or more levels where each of the rendering widgets had been associated to one or more data content source. The method includes transmitting a request for a dataset corresponding to the data content source. The method includes receiving, at the client-side application, the data set where the data set forms a multi-level hierarchy corresponding the one or more levels of the input widget. The method includes displaying a selected rendering widgets with a data content source wherein the selected rendering widgets corresponds to a selected level of the input widget.

Abstract: A system and method for developing real-time web-service objects. The method includes providing a client-side application running on a connected device. The client-side application executes Webpage definition files having a composite Web-service objects, including a first and second composite Web-service objects where each of the object has been associatively linked to a data service from a data source. The method includes receiving, during runtime of the client-side application, a first updated data content from the data source. The method includes caching the first updated data content in memory and, upon receiving a second updated data content, retrieving the first updated data content from memory and updating the composite Web-service objects of the Webpage definition files using the first and second update data contents.

Abstract: A system and method is provided for testing computing devices in a heterogeneous environment. The method includes providing a development workspace for a set of Webpage definition files. The method includes storing, responsive to a save command being received by an input at the development workspace, a set of modified Webpage definition files where the set of modified Webpage definition files includes at least one modification in relation to the Webpage definition files associated with a previous save command. The method includes causing, by a processor responding to the save command, a message to be transmitted to one or more computing devices. The message causes each of the computing device to receive the set of modified Webpage definition files where the receipt of the set of modified Webpage definition files occurs without any input by a user at the client-side application.

Abstract: The present disclosure provides a system and method for managing data using semantic tags. The method may include providing a data model corresponding to a first set of tangible objects where the data model includes a first template class having both properties describing the set of tangible object and a set of semantic tags corresponding to the properties. The method may include receiving a class definition for a second template class for a second set of tangible objects where the second template class inherits, by the class definition, the properties and the sematic tags for the second set of tangible objects.

Abstract: A MEMS fuze having a moveable slider with a microdetonator at an end for positioning adjacent an initiator. A setback activated lock and a spin activated lock prevent movement of the slider until respective axial and centrifugal acceleration levels have been achieved. Once these acceleration levels are achieved, the slider is moved by a V-beam shaped actuator arrangement to position the microdetonator relative to a secondary lead to start an explosive train in a munitions round.

Abstract: A MEMS fuze having a moveable slider with a microdetonator at an end for positioning adjacent an initiator. A setback activated lock and a spin activated lock prevent movement of the slider until respective axial and centrifugal acceleration levels have been achieved. Once these acceleration levels are achieved, the slider is moved by a V-beam shaped actuator arrangement to position the microdetonator relative to a secondary lead to start an explosive train in a munitions round.

Abstract: The invention comprises a micromechanical shock sensor that is formed on the surface of a micro-substrate. A moveable proof mass is formed on the surface with at least one spring connected to the proof mass and the surface. The spring allows the proof mass to move a predetermined distance. Latching means are formed on the surface the predetermined distance from the proof mass. When the sensor is subjected to a sufficient shock, the proof mass moves and contacts the latching means. An indicator means is provided to allow this contact to be readily known by the user.

Abstract: A micromechanical device that takes a vertical force to a micro substrate that results into a vertical motion and translates that vertical motion into horizontal motion. A pit is etched onto a micro substrate where the walls of the pit meet the floor of the pit at less than a 90° angle. A vertical force is applied to a structure to push it along the angled wall of the pit and as the structure reaches the bottom of the pit the vertical motion is translated into horizontal motion. By attaching a spring or similar mechanism to the structure, one can store the horizontal momentum for later use by latching the structure in some way before the spring can pull the structure back into its original position.