Patents by Inventor Lawrence Fang

Lawrence Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of Alzheimer's disease
    Patent number: 7432389
    Abstract: The present invention is substituted amine s of formula (XV) useful in treating Alzheimer's ease and other similar disease.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: October 7, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Lawrence Fang, Varghese John
  • Methods of Treatment of Amyloidosis Using Subsituted Ethanolcyclicamine Aspartyl Protease Inhibitors
    Publication number: 20080166332
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis.
    Type: Application
    Filed: August 26, 2005
    Publication date: July 10, 2008
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Roy Hom, Lawrence Fang, Varghese John
  • Dipeptide inhibitors of ?-secretase
    Patent number: 7276484
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: October 2, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye S. Mamo
  • Compounds to treat Alzheimer's disease
    Publication number: 20070213407
    Abstract: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: September 13, 2007
    Inventors: Lawrence Fang, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Michel Maillard, Varghese John, Shon Pulley, James Beck, Ruth TenBrink, John Freskos
  • N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
    Publication number: 20070213316
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Application
    Filed: December 11, 2006
    Publication date: September 13, 2007
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • N,N?-substituted-1,3-diamino-2-hydroxypropane derivatives
    Patent number: 7176242
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 13, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Tetrapeptide inhibitors of ?-secretase
    Patent number: 7169759
    Abstract: Statine-derived peptide inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and pharmaceutical compositions.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: January 30, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Jay Tung, Lawrence Fang, Shumeye S. Mamo
  • Compounds to treat alzheimer's disease
    Publication number: 20060287306
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: January 31, 2006
    Publication date: December 21, 2006
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Compounds to treat Alzheimer's disease
    Publication number: 20060276642
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: April 17, 2006
    Publication date: December 7, 2006
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Compounds for the treatment of Alzheimer's disease
    Publication number: 20060211860
    Abstract: The present invention is substituted amines of formula (XV) useful in treating Alzheimer's ease and other similar dise
    Type: Application
    Filed: March 7, 2006
    Publication date: September 21, 2006
    Inventors: Lawrence Fang, Varghese John
  • Methods of treating alzheimer's disease
    Publication number: 20060079533
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of 3,4-disubstituted piperidinyl compounds of formula (I) wherein the variables R1, R2, R3, R4, Q, W, X, Z, m, and n are defined herein.
    Type: Application
    Filed: March 21, 2002
    Publication date: April 13, 2006
    Inventors: James Nieman, Lawrence Fang, barbara Jagodzinska
  • Methods of treatment of amyloidosis using ethanolcyclicamine aspartyl protease inhibitors
    Publication number: 20060074098
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: August 26, 2005
    Publication date: April 6, 2006
    Inventors: Roy Hom, Lawrence Fang, Varghese John
  • Compounds to treat Alzheimer's disease
    Patent number: 6992081
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: January 31, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors
    Publication number: 20060014790
    Abstract: The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: January 21, 2005
    Publication date: January 19, 2006
    Inventors: Varghese John, Roy Hom, Jennifer Sealy, Jose Aquino, Gary Probst, Jay Tung, Lawrence Fang
  • Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors
    Publication number: 20050239832
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: October 27, 2005
    Inventors: Varghese John, Michel Maillard, Lawrence Fang, John Tucker, Louis Brogley, Jose Aquino, Simeon Bowers, Gary Probst, Jay Tung
  • Dipeptide inhibitors of beta-secretase
    Publication number: 20050182138
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 18, 2005
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye Mamo
  • Dipeptide inhibitors of ?-secretase
    Patent number: 6864240
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: March 8, 2005
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye S. Mamo
  • N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
    Publication number: 20040171881
    Abstract: Disclosed are compounds of the formula 1
    Type: Application
    Filed: November 8, 2002
    Publication date: September 2, 2004
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Compounds to treat Alzheimer's disease
    Publication number: 20030013881
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) 1
    Type: Application
    Filed: September 21, 2001
    Publication date: January 16, 2003
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Pollen suppressant comprising a 5-oxy- or amino substituted cinnoline
    Patent number: 5696055
    Abstract: Pollen suppressants of the formula ##STR1## wherein X represents a group of the formula OR.sup.1 or NR.sup.1 R.sup.2 wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl (optionally substituted with a C.sub.1 -C.sub.4 alkoxy group, 1 to 3 halogen atoms, or a carboxy or C.sub.1 -C.sub.4 alkylcarbonyl group), alkenyl (optionally substituted with 1 to 3 halogen atoms), or alkynyl group and R.sup.2 represents H or CH.sub.3, with the proviso that when R.sup.1 is C.sub.3, R.sup.2 is CH.sub.3 ; Y is hydrogen, C.sub.1 -C.sub.22 linear alkyl or alkenyl containing up to four C.dbd.C double bonds, C.sub.3 -C.sub.6 branched alkyl or alkenyl, C.sub.2 -C.sub.4 alkoxyalkyl, cyclohexylmethyl, halogenated C.sub.1 -C.sub.4 alkyl, phenyl, benzyl, --(CH.sub.2 CH.sub.2 O).sub.m CH.sub.2 CH.sub.3 in which m is an integer from 1 to 5, or --CH(CH.sub.2 OR.sup.4)CH.sub.2 OR.sup.5 or --CH.sub.2 CHOR.sup.4 CH OR.sup.5 in which either R.sup.4 or R.sup.5 but not both represent a C.sub.1 -C.sub.
    Type: Grant
    Filed: January 6, 1992
    Date of Patent: December 9, 1997
    Assignee: Hybrinova S.A.
    Inventors: Jeffrey Labovitz, William J. Guilford, Yi Liang, Lawrence Fang, Thomas G. Patterson