Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: A data processing apparatus includes circuitry configured to: detect a speech input from a first user playing a video game; transmit data representing the speech input to a second data processing apparatus using a first communication channel for output to a second user playing the video game with the first user; determine if a private conversation mode is enabled; if the private conversation mode is not enabled, transmit data representing the speech input to a third data processing apparatus using a second communication channel for output to a third user watching but not playing the video game with the first and second users; and if the private conversation mode is enabled, prevent transmission of data representing the speech input to the third data processing apparatus using the second communication channel.

Abstract: A data processing apparatus includes processing circuitry to generate images of a computer-generated environment for display to a first user, storage circuitry to temporarily store at least some of the images, where the storage circuitry is configured to temporarily store a respective image in dependence upon one or more storage conditions, receiving circuitry to receive user input data indicative of selection by a first user of a predetermined function for reporting abusive interaction by another user associated with the computer-generated environment, recording circuitry to generate a respective recording in response to the user input data, the respective recording comprising at least some of the images stored by the storage circuitry and output circuitry to output the respective recording

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: This invention is directed to a protective headgear system which includes a relatively light weight, substantially rigid, headgear structure which may include an internal, adjustable headband. The system includes at least one filter which is attachable to the headgear structure to cover the structure and a filter protector mounted thereon. A fan mechanism is mounted on the headgear structure to draw air into the headgear structure through the filter means. A power supply selectively powers the fan. A facial shield is attachable to the headgear structure to cover the face of the wearer to maintain non-contaminating conditions relative to the wearer. A flexible cuff or hood is attachable to the facial shield to enclose the lower opening of the lens and provides protection for the wearer through which air can be exhausted.

Abstract: A system consisting of a hand-piece with a lever operated hydraulic pump and a fluid reservoir, a connecting tube and a remote connector which will seal to a syringe body which contains a viscous material. The pump expels fluid from the reservoir into the top of the syringe via the connecting tube where the fluid presses on the syringe plunger expelling the viscous material from the primary chamber of the syringe.

Abstract: A method and apparatus are described for image sensor optimization. According to an embodiment of the invention, a method comprises capturing an image with an image sensor, the image sensor comprising a plurality of pixels; obtaining an output relating to the image from a first pixel of the plurality of pixels; and normalizing the output from the first pixel to correlate with photon flux striking the image sensor.

Abstract: The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be Mycobacterium bovis or any other Mycobacterium species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of pathogen and/or molecular marker may be screened and detected. Preferred embodiments comprise reflex supplemental testing using the same assay at approximately 100% sensitivity and the highest possible corresponding sensitivity—in one example 70%. Such assay conditions, used iteratively, result in elimination of 70% of uninfected subjects for each round of testing. Use of 4 or more rounds of testing results in less than 1% error. Since only positive samples are retested, the methods provide a rapid, inexpensive and highly accurate way to detect infected subjects.

Abstract: The present invention concerns methods and compositions relating to translucent matrix arrays. In certain embodiments, the arrays are reconfigurable. Reconfigurable arrays may be produced using small linker molecules, such as aptamers or affibodies, which preferably bind to an IgG specific portion of antibodies. Such arrays may be used to detect any target that binds selectively or specifically to an IgG. Translucent matrix arrays may utilize cellophane, rayon or a translucent, colloidal form of nitrocellulose to coat the substrate. Other embodiments concern methods of data analysis and apparatus for analyte detection. Certain embodiments concern a total optical assay device (TOAD™), which may be used with GRABBER™ slides and/or FOOTPAD™ microtiter well assay devices.

Abstract: Disclosed are methods of inhibiting neovascularization in a subject by administering to the subject a pharmaceutical preparation of R?-Glu-Trp-R?.

Abstract: The present disclosure concerns methods of detecting counterfeit liquid and/or food products, particularly those used for human consumption. In certain embodiments, the claimed methods may comprise adding two or more markers to a liquid or food product, releasing the product into a stream of commerce, obtaining one or more samples purported to be the liquid or food product and assaying the samples for the presence of the markers, wherein the absence of at least one of the markers indicates that the product is counterfeit, fake or otherwise not authentic.

Abstract: A system consisting of a hand-piece with a lever operated hydraulic pump and a fluid reservoir, a connecting tube and a remote connector which will seal to a syringe body which contains a viscous material. The pump expels fluid from the reservoir into the top of the syringe via the connecting tube where the fluid presses on the syringe plunger expelling the viscous material from the primary chamber of the syringe.

Abstract: This invention is directed to a protective headgear system which includes a relatively light weight, substantially rigid, headgear structure which may include an internal, adjustable headband. A fan mechanism is mounted on the headgear structure. A power supply selectively powers the fan. The system includes filter means which is attachable to the headgear structure to cover the structure. A facial shield is attachable to the headgear structure to cover the face of the wearer to maintain non-contaminating conditions relative to the wearer. A shield protector is attachable to the facial shield. A flexible cuff is attachable to the facial shield to enclose the lower opening of the lens and provide protection for the wearer.

Abstract: This invention is directed to a protective headgear system which includes a relatively light weight, substantially rigid, headgear structure which may include an internal, adjustable headband. A fan mechanism is mounted on the headgear structure. A power supply selectively powers the fan. The system includes filter means which is attachable to the headgear structure to cover the structure. A facial shield is attachable to the headgear structure to cover the face of the wearer to maintain non-contaminating conditions relative to the wearer. A shield protector is attachable to the facial shield. A flexible cuff is attachable to the facial shield to enclose the lower opening of the lens and provide protection for the wearer.