Patents by Inventor Lawrence H. CHEUNG

Lawrence H. CHEUNG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20230203467
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: November 3, 2022
    Publication date: June 29, 2023
    Applicant: Research Development Foundation
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • Serine protease molecules and therapies
    Patent number: 11535838
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: December 27, 2022
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • Serine protease molecules and therapies
    Patent number: 10920211
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: February 16, 2021
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20200308565
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 1, 2020
    Applicant: Research Development Foundation
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • Serine protease molecules and therapies
    Patent number: 10738295
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: August 11, 2020
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20200010821
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: September 19, 2019
    Publication date: January 9, 2020
    Applicant: Research Development Foundation
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20190256837
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Applicant: Research Development Foundation
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • Serine protease molecules and therapies
    Patent number: 10323239
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: June 18, 2019
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20180201918
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: March 9, 2018
    Publication date: July 19, 2018
    Applicant: Research Development Foundation
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • Serine protease molecules and therapies
    Patent number: 9951325
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: April 24, 2018
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • Serine protease molecules and therapies
    Patent number: 9499807
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 22, 2016
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • Serine protease molecules and therapies
    Patent number: 9096840
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: August 4, 2015
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20150010556
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20140314760
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20140140976
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: October 4, 2013
    Publication date: May 22, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG