Patents by Inventor Lawrence H. Lazarus

Lawrence H. Lazarus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dmt-derivative compounds and related compositions and methods of use
    Patent number: 8030341
    Abstract: The present invention relates to symmetric and asymmetric dimeric Dmt (2?,6?-ditnethyl) compounds and Dmt derivative compounds with dual ? and ? opioid receptor antagonist activity. Also, the present invention provides compositions comprising these compounds and it provides methods of using these compounds.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: October 4, 2011
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Kobe Gakuin University
    Inventors: Lawrence H. Lazarus, Yoshio Okada, Tingyou Li
  • Dmt-Derivative Compounds and Related Compositions and Methods of Use
    Publication number: 20080269143
    Abstract: The present invention relates to symmetric and asymmetric dimeric Dmt (2?,6?-ditnethyl) compounds and Dmt derivative compounds with dual ? and ? opioid receptor antagonist activity. Also, the present invention provides compositions comprising these compounds and it provides methods of using these compounds.
    Type: Application
    Filed: August 30, 2006
    Publication date: October 30, 2008
    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY,
    Inventors: Lawrence H. Lazarus, Yoshio Okada, Tingyou Li
  • Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use
    Patent number: 6916905
    Abstract: A compound of formula: wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: July 12, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence H. Lazarus, Severo Salvadori
  • Opioid derivative
    Patent number: 6838580
    Abstract: 1. A peptide derivative represented by the following formula (1) or a salt thereof; wherein R1 is hydrogen atom or methyl group, R2 is hydrogen atom or hydroxy group and n is an integer of 1-8, provided that R1 is hydrogen atom when R2 is hydrogen atom, which has specific and high binding affinity with the ?-opioid receptor.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: January 4, 2005
    Assignee: Teikoku Seiyaku Co., Ltd.
    Inventors: Yoshio Okada, Yuko Tsuda, Toshio Yokoi, Sharon D. Bryant, Lawrence H. Lazarus
  • Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use
    Patent number: 6753317
    Abstract: A compound of formula: comprising the Dmt-Tic pharmacophore and related compositions and methods of use in the inhibition of the binding of an opioid receptor-binding compound with a P-glycoprotein, specifically hMDR-1, are provided.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: June 22, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence H. Lazarus, Severo Salvadori
  • Opioid derivative
    Publication number: 20030171302
    Abstract: 1.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 11, 2003
    Inventors: Yoshio Okada, Yuko Tsuda, Toshio Yokoi, Sharon D. Bryant, Lawrence H. Lazarus
  • Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use
    Publication number: 20020161189
    Abstract: A compound of formula: 1
    Type: Application
    Filed: December 21, 2001
    Publication date: October 31, 2002
    Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
    Inventors: Lawrence H. Lazarus, Severo Salvadori
  • Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
    Patent number: 5780589
    Abstract: Novel opioidmimetic dipeptides, tripeptides and cyclic peptides exhibit enhanced affinity and selectivity for .delta. opioid receptors. The peptides are represented by the formulas L/D-Dmt-L-/D-Tic-R', L/D-Dmt-L-/D-Tic-R-R' and cyclic (L/D-Dmt-L/D-Tic) wherein Dmt is 2',6',-dimethyl-L/D-tyrosine Tic is L-/D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, R is a natural or unusual aliphatic amino residue and R' is a functional group at the carboxyl terminus of the peptide. Pharmacological and therapeutic and compositions are also provided.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: July 14, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence H. Lazarus, Severo Salvadori, Piero Andrea Temussi