Patents by Inventor Lawrence H. Young

Lawrence H. Young has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of MIF and MIF pathway agonists
    Patent number: 10765739
    Abstract: The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of MIF, identifying a subject at risk for developing a condition in which increased AMPK activity is desirable, and for predicting whether a subject is susceptible to a condition in which increased AMPK activity is desirable.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: September 8, 2020
    Assignee: Yale University
    Inventors: Richard Bucala, Lawrence H. Young
  • USE OF MIF AND MIF PATHWAY AGONISTS
    Publication number: 20180008705
    Abstract: The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of MIF, identifying a subject at risk for developing a condition in which increased AMPK activity is desirable, and for predicting whether a subject is susceptible to a condition in which increased AMPK activity is desirable.
    Type: Application
    Filed: July 13, 2017
    Publication date: January 11, 2018
    Inventors: Richard Bucala, Lawrence H. Young
  • Compositions and Methods for Diagnosing and Treating Diseases and Disorders Associated With D-DT
    Publication number: 20160258966
    Abstract: The present invention relates to the discovery that altered levels of D-DT (also known as MIF-2) are associated with disorders and diseases. Thus, the present invention relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with an elevated level of D-DT. The present invention also relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with a reduced level of D-DT.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Inventors: Richard J. Bucala, Lawrence H. Young
  • Methods of administering D-dopachrome tautomerase (D-DT) to treat ischemia-reperfusion injury
    Patent number: 9308255
    Abstract: The present invention relates to the discovery that reduced levels of D-dopachrome tautomerase (D-DT) (also known as MIF-2) are associated with ischemia-reperfusion injury. Thus, the present invention relates to methods of administering D-DT and recombinant D-DT for the treatment of ischemia-reperfusion injury.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 12, 2016
    Assignee: Yale University
    Inventors: Richard J. Bucala, Lawrence H. Young
  • Compositions and Methods for Diagnosing and Treating Diseases and Disorders Associated With D-DT
    Publication number: 20140030266
    Abstract: The present invention relates to the discovery that altered levels of D-DT (also known as MIF-2) are associated with disorders and diseases. Thus, the present invention relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with an elevated level of D-DT. The present invention also relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with a reduced level of D-DT.
    Type: Application
    Filed: November 23, 2011
    Publication date: January 30, 2014
    Applicant: Yale University
    Inventors: Richard J. Bucala, Lawrence H. Young