Abstract: Methods, systems, and computer programs encoded on computer storage media, for implementing MPP relational databases using containers. One example system initiates primary containers to implement database segment instances. Each segment of the database is stored on a respective storage volume. Each storage volume is mounted on a respective primary container. The system detects a failure of a first primary container that is a segment instance of a first database segment. In response to the detection, the system performs a recovery process. The system unmounts, from the failed first primary container, a first storage volume storing the first database segment. The system selects a standby container from a pool of standby containers and mounts the first storage volume on the selected standby container. The system is reconfigured so that it processes queries for the first database segment using the selected standby container instead of the failed first container.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for allocating a number of first containers to implement one primary segment instance each and a number of second containers to implement one mirror segment instance each. In one example system, the second containers are configured to have less computing resources than the first containers. The containers are distributed among a number of physical computers. The system receives an indication of a failure of a physical computer hosting a particular first container implementing a first primary segment instance. In response to receiving the indication, the system promotes a second mirror segment instance that is a mirror of the first primary segment instance to be a new primary segment instance. The system allocates additional resources to the particular second container implementing the promoted mirror segment instance.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for allocating a number of first containers to implement one primary segment instance each and a number of second containers to implement one mirror segment instance each. In one example system, the second containers are configured to have less computing resources than the first containers. The containers are distributed among a number of physical computers. The system receives an indication of a failure of a physical computer hosting a particular first container implementing a first primary segment instance. In response to receiving the indication, the system promotes a second mirror segment instance that is a mirror of the first primary segment instance to be a new primary segment instance. The system allocates additional resources to the particular second container implementing the promoted mirror segment instance.

Abstract: Methods, systems, and computer programs encoded on computer storage media, for implementing MPP relational databases using containers. One example system initiates primary containers to implement database segment instances. Each segment of the database is stored on a respective storage volume. Each storage volume is mounted on a respective primary container. The system detects a failure of a first primary container that is a segment instance of a first database segment. In response to the detection, the system performs a recovery process. The system unmounts, from the failed first primary container, a first storage volume storing the first database segment. The system selects a standby container from a pool of standby containers and mounts the first storage volume on the selected standby container. The system is reconfigured so that it processes queries for the first database segment using the selected standby container instead of the failed first container.

Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms via the oral transmucosal route of a subject for treatment of pain.

Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms via the oral transmucosal route of a subject for treatment of pain.

Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.

Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

Abstract: A method and apparatus are provided for designing educational assessments. In one embodiment, a method for guiding a user in the design of an assessment includes receiving, from the user, one or more goals relating to the assessment and translating those goals into a task specification for an assessment task in accordance with one or more user-defined variables.

Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.

Abstract: A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed.

Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.