Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

Abstract: Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the Formula (I). Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided.

Abstract: Lipid nanoparticle compositions for delivery of nucleic acids are described. The lipid nanoparticle may contain a conformationally constrained ionizable lipid as part of the composition. These compositions may allow for delivery of cargo without the need for a targeting ligand.

Abstract: A method and apparatus for lifting, transporting, or installing a commode is disclosed. The commode lifting and transporting device includes a base frame, with an upright support frame designed to straddle and lift a commode at or near the commode's center of gravity. The lifting member includes a screw jack, a lifting bar guided by the upright support frame, and three methods of attaching the commode to the commode lifting device: a self-clamping mechanism for lifting and transporting standard commodes; a set of support hooks and chain for lifting and transporting non-standard commodes, and lifting bar holes used in conjunction with the commode's seat holes, two bolts and two nuts as an alternate method for lifting and transporting non-standard commodes.

Abstract: A weight distribution and suspension system is disclosed. This system provides comfort for the human body in a seated position by using a plurality of foam layers of alternating densities and elasticities to form a seat cushion. In one embodiment, the system is comprised of a plurality of foam layers of alternating densities and elasticities, a vinyl cushion cover, a second layer of vinyl, covering the top surface and creating a pocket, a fabric cushion backing, a mesh pocket for holding small items, a nylon zipper, and one or more elastic bands for holding small items. In this embodiment the system is intended to provide user comfort in stadium seating.

Abstract: An organizer component system provides multiple features that may be used independently or in combination to organize a variety of objects. The user can select from a variety of organizing apparatuses, components and system accessories based on user preference. Organizing apparatuses include, among others, those suitable for the desktop, for a computer monitor, for a corner and for a cubicle partition. This system can be used to organize items in the bathroom, craft are, shop area, garage, or simply to display photos anywhere.