Abstract: Compounds of the general formula I and physiologically acceptable acid addition salts thereof:- ##STR1## in which R.sup.1 is a lower alkyl, lower alkenyl, or arylalkyl radical, which radicals may optionally be substituted by one or more alkoxy or hydroxy groups.R.sup.2 represents a hydrogen atom or a lower alkyl radical which may optionally be substituted by one or more hydroxy groups, amino groups, or heterocyclic rings containing one or more heteroatoms, or R.sup.2 represents a cycloalkyl, arylalkyl or aryloxyalkyl radical, which radicals may optionally be substituted by one or more alkoxy or hydroxy groups;R.sup.3 represents a hydrogen atom or a benzyl group;X represents a group of formula --CONR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 may be the same or different and each represents hydrogen or a lower alkyl group;With the proviso that when R.sup.2 is tertiary butyl and R.sup.1 is a benzyl group, R.sup.3 represents a hydrogen atom. The compounds have a blocking action on .beta.

Abstract: Compounds of the formula: ##STR1## and physiologically acceptable acid addition salts thereof, in which R.sup.1 isA. an arylalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms and the aryl portion of which may be substituted by one or more alkoxy groups or hydroxy groups; orB. an aryloxyalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms, and the aryloxy portion of which is substituted with one or more alkoxy or hydroxy groups.These compounds have a blacking action on both .alpha.- and .beta.-adrenergic receptors and are useful in treating hypertension. Processes for the production of these compounds and pharmaceutical compositions containing them are also provided.

Abstract: Compounds of the formula: ##STR1## and physiologically acceptable acid addition salts thereof, in which R.sup.1 isA. an arylalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms and the aryl portion of which may be substituted by one or more alkoxy groups or hydroxy groups; orB. an aryloxyalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms, and the aryloxy portion of which is substituted with one or more alkoxy or hydroxy groups.These compounds have a blocking action on both .alpha.- and .beta.-adrenergic receptors. Processes for the production of these compounds and pharmaceutical compositions containing them are also provided.

Abstract: Compounds of the formula: ##STR1## in which: R.sub.4 and R.sub.5 independently represent hydrogen or lowr alkyl;R.sub.6 represents a straight or branched alkyl or alkenyl group containing from 4 to 6 carbon atoms, inclusive, orR.sub.6 represents a straight or branched alkyl group containing from 2 to 6 carbon atoms, inclusive, which alkyl group is substituted by one or more hydroxy, alkoxy or acyloxy groups; or by an aryl group which may be substituted by one or more hydroxy, alkoxy or acyloxy groups as before; andR.sub.7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an alkoxy group or by an aryl or aryloxy group which, alkoxy, aryl or aryloxy group may, in turn be substituted by hydroxy, alkoxy, acetamido or methanesulphonamido groups,And pharmaceutically acceptable salts thereof. These compounds have utility in the treatment of cardiovascular diseases.

Abstract: Compounds of the formula ##STR1## in which: R.sub.4 and R.sub.5 independently represent hydrogen or lower alkyl;R.sub.6 represents a group Y(CH.sub.2).sub.n, in which n is 2 or 3 andY represents a straight or branched chain alkyl group containing 5 carbon atoms optionally substituted with one more hydroxy or alkoxy groups or by aryl groups which may, in turn, contain hydroxy or alkoxy substituents; orY represents a group ZO--, in which Z represents a straight or branched alkyl group containing from 2 to 6 carbon atoms inclusive substituted by one or more alkoxy, hydroxy, or aryloxy groups; or Z represents an aryl group which may, optionally, contain one or more hydroxy or alkoxy substituents; andR.sub.7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an aryl or aryloxy group which aryl or aryloxy group may, in turn be substituted by hydroxy and alkoxy groupsAnd pharmaceutically acceptable salts thereof.