Patents by Inventor Lawrence I. Greenfield

Lawrence I. Greenfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONTROL OF CHEMICAL MODIFICATION
    Publication number: 20100009342
    Abstract: Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid support for the label, reducing the number of labels available to conjugates to the carrier molecule or solid support. This provides for a facile method that predictably alters the DOL of a carrier molecule or solid support.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 14, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: John Matthew MAURO, Thomas Harry STEINBERG, Lawrence I. GREENFIELD, Louis LEONG
  • CONTROL OF CHEMICAL MODIFICATION
    Publication number: 20080176213
    Abstract: Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid support for the label, reducing the number of labels available to conjugates to the carrier molecule or solid support. This provides for a facile method that predictably alters the DOL of a carrier molecule or solid support.
    Type: Application
    Filed: March 27, 2008
    Publication date: July 24, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: John Matthew Mauro, Thomas Harry Steinberg, Lawrence I. Greenfield, Louis Leong
  • Toxin conjugates
    Patent number: 4894443
    Abstract: A novel class of polypeptides of the general formula (F-(Pro).sub.n).sub.m F, wherein F represents a flexible amino acid sequence wherein each amino acid is individually selected from the group consisting of serine, glycine, and threonine, and n is an integer from 4-8 inclusive and m is an integer from 1-4 inclusive, is disclosed. Thses polypeptides are useful in the construction of conjugates between antibodies and peptide toxins. The preparation of such conjugate toxins by linking antibodies to toxin/spacer composites prepared by recombinant techniques is also disclosed.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: January 16, 1990
    Assignee: Cetus Corporation
    Inventors: Lawrence I. Greenfield, Donald A. Kaplan, Danute E. Nitecki
  • Recombinant diphtheria toxin fragments
    Patent number: 4830962
    Abstract: Recombinant vectors which are effective in expressing DNA sequences encoding specific fragments of diphtheria toxins at high levels in recombinant host cells are disclosed. Both a fragment consisting of the enzymatically active A chain of diphtheria toxin and a fragment consisting of both the A portion and a B portion partial sequence are constructed by use of this recombinant vector.
    Type: Grant
    Filed: February 9, 1984
    Date of Patent: May 16, 1989
    Assignee: Cetus Corporation
    Inventors: David H. Gelfand, Lawrence I. Greenfield, Frances C. Lawyer