Patents by Inventor Lawrence Klecha

Lawrence Klecha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of discovery ion currents and mass spectrometry and uses thereof
    Patent number: 10037872
    Abstract: Systems for the generation of discovery ion currents. One of the systems includes a mass spectrometer providing ion current measurement. The system includes a controller coupled to the mass spectrometer. The system also includes a liquid handler coupled to the controller and the mass spectrometer. The controller is configured to identify a base average ion current of each mass to charge interval, the mass to charge interval comprising at least one mass to charge channel. The controller is configured to calculate a relative change between a current ion current measurement for a charge interval to the base average for the charge interval. The controller is configured to compare the relative change to a threshold. The controller is also configured to, in response to determining that the relative change exceeds the threshold, start fraction collection using the liquid handler.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 31, 2018
    Assignee: Advion Inc.
    Inventor: Lawrence Klecha
  • GENERATION OF DISCOVERY ION CURRENTS AND MASS SPECTROMETRY AND USES THEREOF
    Publication number: 20180204711
    Abstract: Systems for the generation of discovery ion currents. One of the systems includes a mass spectrometer providing ion current measurement. The system includes a controller coupled to the mass spectrometer. The system also includes a liquid handler coupled to the controller and the mass spectrometer. The controller is configured to identify a base average ion current of each mass to charge interval, the mass to charge interval comprising at least one mass to charge channel. The controller is configured to calculate a relative change between a current ion current measurement for a charge interval to the base average for the charge interval. The controller is configured to compare the relative change to a threshold. The controller is also configured to, in response to determining that the relative change exceeds the threshold, start fraction collection using the liquid handler.
    Type: Application
    Filed: August 29, 2017
    Publication date: July 19, 2018
    Inventor: Lawrence Klecha
  • Generation of discovery ion currents and mass spectrometry and uses thereof
    Patent number: 9779922
    Abstract: Systems for the generation of discovery ion currents. One of the systems includes a mass spectrometer providing ion current measurement. The system includes a controller coupled to the mass spectrometer. The system also includes a liquid handler coupled to the controller and the mass spectrometer. The controller is configured to identify a base average ion current of each mass to charge interval, the mass to charge interval comprising at least one mass to charge channel. The controller is configured to calculate a relative change between a current ion current measurement for a charge interval to the base average for the charge interval. The controller is configured to compare the relative change to a threshold. The controller is also configured to, in response to determining that the relative change exceeds the threshold, start fraction collection using the liquid handler.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: October 3, 2017
    Assignee: Advion Inc.
    Inventor: Lawrence Klecha