Abstract: A device and method operated thereby may control a hydraulic pump to pump a hydraulic fluid into a chamber of a piston coupled to a fifth wheel of the tractor to raise the fifth wheel. The device, and method operated thereby, may sense, at intervals as the fifth wheel rises, a pressure value of the hydraulic fluid in the chamber. The device, and method operated thereby, may process the pressure values to determine when the landing gear is lifted off the ground.

Abstract: Systems and methods determines that a trailer being towed by an autonomous electric tractor has its brakes applied when a motor current value of a drive motor of the autonomous electric tractor reaches or exceeds a first current threshold. a recover handler initiates a set of actions to recover resolve the trailer brake problem. A trailer lift status indicating whether a landing gear of the trailer is off the ground and a lift metric indicative of a height of the landing gear off the ground are determined by a perception module using one or more of images, point clouds, and radar data that include the trailer.

Abstract: A device and method operated thereby may control a hydraulic pump to pump a hydraulic fluid into a chamber of a piston coupled to a fifth wheel of the tractor to raise the fifth wheel. The device, and method operated thereby, may sense, at intervals as the fifth wheel rises, a pressure value of the hydraulic fluid in the chamber. The device, and method operated thereby, may process the pressure values to determine when the landing gear is lifted off the ground.

Abstract: A method for improving processing of data from a plurality of data sources by extracting signals from data sets includes retrieving the data from the plurality of data sources, generating a correlation matrix or a covariance matrix based on the retrieved data, performing an eigenvalue decomposition on the correlation matrix or the covariance matrix to determine a set of eigenvector loadings, and converting a result of the eigenvalue decomposition into an indicator of a common signal among the retrieved data. Converting the result of the eigenvalue decomposition into the indicator of the common signal includes applying a loading from the set of eigenvector loadings as a weight to at least one corresponding observation in the retrieved data from the plurality of data sources, and recursively repeating the steps of retrieving, generating, performing, and converting.

Abstract: Systems and methods determine an angle of an articulated trailer relative to a tractor that the trailer is hitched to. An optical encoder is positioned beneath a fifth-wheel of a tractor to couples with a kingpin of the trailer when the trailer is hitched to the tractor. The optical coupler has a rotating shaft that may include pins that physically interact with the kingpin and/or may include a magnet that magnetically attaches to the kingpin. A clearance and cleaning block may be positioned on the spring plate to interact with a bottom surface of a kingpin of the trailer during hitching of the trailer to the tractor. A LIDAR attached to the tractor may detect a front end of the trailer to determine the trailer angle relative to the tractor.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with ANGPTL3 whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of ANGPTL3 gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN10A gene in a cell by genome editing.

Abstract: A path for an autonomous tractor to move a trailer from a start spot to an ending spot has at least one path segment and a variation indicator that indicates a path variant for the autonomous tractor to follow for the path segment. The autonomous tractor follows the path variant to reduce wear caused by repetitive use of the same path by the autonomous tractor. The path variant may be selected as a least frequented path variant or may be selected as having carried the least amount of weight.

Abstract: Systems and methods for creating indicators to quantify and index financial market liquidity risk that is marked wide among a broad set of securities or asset classes or portfolio specific relative to an individual investor's portfolio holdings. A liquidity risk index can be created as a counterpart to any well-known market index, such as the Dow Jones Industrial Average® or the S&P 500® index. The present disclosure relates to risk management in financial markets and in particular to systems and methods for quantifying and indexing liquidity risk such that these indices can serve as underlying assets for futures, options, or other financial instruments that investors would use to hedge against the liquidity risk.

Abstract: Various embodiments of the present technology generally relate to systems and methods for secure customer data handling. More specifically, some embodiments relate to handling of derivative data as a provider in a manner that supports security and provides a stronger level of control over the data. The solution supports four core principles of customer data handling: no export of customer data, unless authorized; remote operations only via shell access or equivalent; temporary and task-based privileges; and diagnostic data to be ephemeral. The customer data handling system herein includes a central repository for the storage of diagnostic data, an upload tool for uploading to the central repository and automated staging on containers, a diagnostic virtual machine that enables task-based access to diagnostic data and analysis tools hosted on a dedicated container, and an application for handling requests, provisioning and staging containers, and purging.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN10A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more condition associated with FXN whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of FXN gene in a cell by genome editing.

Abstract: A method detects and prevents stall of a drive motor of an autonomous electric tractor. A stall detector receives, at intervals, a motor current value from a drive circuit of the autonomous electric tractor, determines when the motor current value reaches or exceeds a first current threshold and applies brakes, inhibits a throttle controlling the drive motor, and sets a motor stall flag. A method determines a height above the ground of a landing gear of a trailer coupled with a tractor. A lift detector controls a hydraulic pump to pump a hydraulic fluid into a chamber of a piston coupled to a fifth wheel of the tractor to raise the fifth wheel. The lift detector senses, at intervals as the fifth wheel rises, a pressure value of the hydraulic fluid in the chamber and processes the pressure value to determine when the landing gear is lifted off the ground.

Abstract: Materials and methods for producing genome-edited cells engineered to express a chimeric antigen receptor (CAR) construct on the cell surface, and materials and methods for genome editing to modulate the expression, function, or activity of one or more immuno-oncology related genes in a cell, and materials and methods for treating a patient using the genome-edited engineered cells.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN9A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN9A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with DMPK whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of DMPK gene in a cell by genome editing.

Abstract: A RADAR system and associated methods are used to detect obstacles obscured from view when backing a trailer. An autonomous tractor is equipped with a rear facing RADAR device that has a field-of-view under the trailer and is configured to output RADAR returns from reflections. A controller of the tractor classifies RADAR returns from the RADAR device according to a number of reflections by a dock wall and a trailer face (e.g., a back end of the trailer) of a corresponding RADAR beam. The RADAR returns are correlated based on distance, and distance of a RADAR return from an obstacle is corrected based on the number of reflections. Advantageously, by processing RADAR returns from both direct and reflected RADAR beams, the controller is able to detect obstacles hidden behind the trailer and flag the obstacles as a hazard.

Abstract: Materials and methods for producing genome-edited cells engineered to express a chimeric antigen receptor (CAR) construct on the cell surface, and materials and methods for genome editing to modulate the expression, function, or activity of one or more immuno-oncology related genes in a cell, and materials and methods for treating a patient using the genome-edited engineered cells.

Abstract: A variety of signal extraction algorithms are employed to construct indicators or synthetic data proxy variables or factors from one or multiple data sources with specialized data handling options to resolve problems associated with economic and financial data: revisions, missing observations, publication lags, spontaneous arrival. A forecast evaluation module aids in the selection of the signal extraction procedure that has produced the most accurate factor.

Abstract: Systems and methods for creating indicators to quantify and index correlation risk that is market-wide among a broad set of asset classes or portfolio specific relative to an investor's portfolio holdings. The present disclosure relates to risk management in financial markets, and in particular to systems and methods for quantifying and indexing correlation risk such that these indices can serve as underlying assets for futures and options or other financial instruments that investors would use to hedge against the risk.