Patents by Inventor Lawrence Koupal

Lawrence Koupal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing cholesterol lowering compounds
    Patent number: 5244795
    Abstract: This invention relates to processes employing cultures which are useful for preparing compounds of structural formula (I).
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: September 14, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Lawrence Koupal
  • Antimigraine alkyl indole
    Patent number: 5233050
    Abstract: An alkyl indole of the formula: ##STR1## is a useful antimigraine agent.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Robert P. Borris, Yiu-Kuen T. Lam, Lawrence Koupal
  • Antiviral agent
    Patent number: 5183826
    Abstract: An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: February 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Otto D. Hensens, Lawrence Koupal, Russell B. Lingham, John G. Ondeyka, Deborah L. Zink
  • Culture of Asperigillus versicolor and mutants thereof
    Patent number: 5151365
    Abstract: This invention relates to cultures and processes employing these cultures which are useful for preparing compounds of structural formula (I).
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: September 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Lawrence Koupal
  • Renin-inhibitory pepstatin phenyl derivatives
    Patent number: 4980283
    Abstract: A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: June 2, 1989
    Date of Patent: December 25, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Leeyuan Huang, Joseph Dunn, Jr., Lawrence Koupal, Jerrold Liesch, Otto Hensens, H. Boyd Woodruff
  • Renin-inhibitory pepstatin phenyl derivatives
    Patent number: 4874745
    Abstract: A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: October 17, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Leeyuan Huang, Lawrence Koupal, Joseph Dunn, Jr., Jerrold M. Liesch, Otto Hensens, H. Boyd Woodruff