Abstract: The present invention provides compositions and methods involving the use of a carboxylate graft polymer having high molecular weight and low ratio of acid-to-polyoxyalkylene groups. Such clay-mitigation is particularly useful for treating clay and clay-bearing aggregates, particularly those aggregates used for construction purposes. The present invention minimizes the need to wash the aggregates, thus preserving fine aggregates (“fines”) content in construction materials, and thereby beneficiating the performance and/or properties of construction materials containing the clay-bearing aggregates.

Abstract: The present invention provides compositions and methods involving the use of a carboxylate graft polymer having high molecular weight and low ratio of acid-to-polyoxyalkylene groups. Such clay-mitigation is particularly useful for treating clay and clay-bearing aggregates, particularly those aggregates used for construction purposes. The present invention minimizes the need to wash the aggregates, thus preserving fine aggregates (“fines”) content in construction materials, and thereby beneficiating the performance and/or properties of construction materials containing the clay-bearing aggregates.

Abstract: The present invention provides compositions and methods involving the use of a carboxylate graft polymer having high molecular weight and low ratio of acid-to-polyoxyalkylene groups. Such clay-mitigation is particularly useful for treating clay and clay-bearing aggregates, particularly those aggregates used for construction purposes. The present invention minimizes the need to wash the aggregates, thus preserving fine aggregates (“fines”) content in construction materials, and thereby beneficiating the performance and/or properties of construction materials containing the clay-bearing aggregates.

Abstract: An interface device for interfacing a user with a computer, the computer running an application program and generating a graphical image and a graphical object, comprises a user manipulatable object in communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation.

Abstract: An interface device for interfacing a user with a computer, the computer miming an application program and generating a graphical image and a graphical object, comprises a user manipulatable object in communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation.

Abstract: An interface device for interfacing a user with a computer, the computer running an application program and generating a graphical image and a graphical object, comprises a user manipuatable object in, communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image, and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation.

Abstract: The present invention is directed to the identification, characterization and three-dimensional structure of a novel ligand binding site of KSP. Binding of ligands to the novel binding site result in a conformational change in the three-dimensional structure of the protein and a modulation of the activity of KSP. This conformational change in turn results in the formation of a novel binding pocket in the KSP protein, which comprises the novel binding site of the instant invention.

Abstract: An interface device for interfacing a user with a computer, the computer running an application program and generating a graphical image and a graphical object, comprises a user manipuatable object in, communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image, and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation.

Abstract: An interface device for interfacing a user with a computer, the computer running an application program and generating a graphical image and a graphical object, comprises a user manipulatable object in communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation.