Patents by Inventor Lawrence M. Nelson

Lawrence M. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATER-protein specific antibodies and methods of use
    Patent number: 7531635
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. MATER-protein specific binding agents, such as antibodies, are described. Methods are described for detecting MATER protein in a subject, including methods for determining whether a subject has a biological condition associated with abnormal Mater expression. Also provided are kits for detecting MATER protein in a subject.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: May 12, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Lawrence M. Nelson, Zhi-Bin Tong
  • Methods of detection of MATER protein autoantibodies
    Patent number: 7432067
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for detecting an autoimmune response to MATER in a subject by detecting autoantibodies that recognize an epitope of a MATER protein. Also provided are methods for diagnosis of infertility or reduced fertility by detecting presence of MATER protein autoantibodies in a subject. The disclosure also describes kits for detecting MATER autoantibodies comprising MATER protein.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: October 7, 2008
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services & The National Institutes of Health
    Inventors: Lawrence M. Nelson, Zhi-Bin Tong
  • Human gene critical to fertility
    Patent number: 7217811
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: May 15, 2007
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence M. Nelson, Zhi-Bin Tong
  • Human gene critical to fertility
    Patent number: 7189812
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility, and kits related to such methods. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: March 13, 2007
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lawrence M. Nelson, Zhi-Bin Tong
  • Human gene critical to fertility
    Publication number: 20040072297
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility, and kits related to such methods. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 15, 2004
    Applicant: The Government of the USA as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Lawrence M. Nelson, Zhi-Bin Tong
  • Human gene critical to fertility
    Publication number: 20040028669
    Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
    Type: Application
    Filed: April 16, 2003
    Publication date: February 12, 2004
    Inventors: Lawrence M Nelson, Zhi-Bin Tong