Patents by Inventor Lawrence M. Pfeffer

Lawrence M. Pfeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bromodomain inhibitors to target therapy-resistant cancer
    Patent number: 12329755
    Abstract: Novel inhibitors of the bromodomain of Brahma-related gene 1 (BRG1) are described. Also described are methods of treating glioblastoma using inhibitors of the BRG1 bromodomain in combination with chemotherapeutics, such as DNA alkylating agents. As described herein, the inhibitors sensitize glioblastoma cells, including chemoresistant glioblastoma cells, to DNA alkylating agents, for example, temozolomide and carmustine.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: June 17, 2025
    Assignee: University of Tennessee Research Foundation
    Inventors: Duane Miller, Lawrence M. Pfeffer, Yali He, Debolina Ganguly
  • BROMODOMAIN INHIBITORS TO TARGET THERAPY-RESISTANT CANCER
    Publication number: 20220296592
    Abstract: Novel inhibitors of the bromodomain of Brahma-related gene 1 (BRG1) are described. Also described are methods of treating glioblastoma using inhibitors of the BRG1 bromodomain in combination with chemotherapeutics, such as DNA alkylating agents. As described herein, the inhibitors sensitize glioblastoma cells, including chemoresistant glioblastoma cells, to DNA alkylating agents, for example, temozolomide and carmustine.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 22, 2022
    Inventors: Duane Miller, Lawrence M. Pfeffer, Yali He, Debolina Ganguly
  • Method to detect sensitivity to alpha-interferon therapy
    Patent number: 5145773
    Abstract: This invention provides a method of detecting sensitivity to alpha-interferon therapy which comprises contacting a sample with a monoclonal antibody under conditions so as to form an antibody-antigen complex, detecting the complex so formed, and thereby detecting sensitivity to alpha-interferon.
    Type: Grant
    Filed: May 25, 1989
    Date of Patent: September 8, 1992
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Anthony P. Albino, David M. Nanus, Neil H. Bander, Lawrence M. Pfeffer