Patents by Inventor Lawrence MacPherson

Lawrence MacPherson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SONIC HEDGEHOG MODULATORS
    Publication number: 20160046590
    Abstract: Sonic Hedgehog modulators and methods of use thereof are provided for.
    Type: Application
    Filed: March 23, 2015
    Publication date: February 18, 2016
    Inventors: Sara Buhrlage, Chris Dockendorff, Mike Foley, Han-Je Kim, Andrew Germain, Lawrence MacPherson, Partha Pratim Nag, Stuart Schreiber, Amal Ting, Michel Weiwer, Willmen Youngsaye
  • SONIC HEDGEHOG MODULATORS
    Publication number: 20140094462
    Abstract: Sonic Hedgehog modulators and methods of use thereof are provided for.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 3, 2014
    Inventors: Sara Buhrlage, Chris Dockendorff, Mike Foley, Han-Je Kim, Andrew Germain, Lawrence MacPherson, Partha Nag, Stuart Schreiber, Amal Ting, Michel Weiwer, Willmen Youngsaye
  • COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS
    Publication number: 20130331411
    Abstract: The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a compound of Formula I or a prodrug or metabolite thereof.
    Type: Application
    Filed: September 23, 2011
    Publication date: December 12, 2013
    Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, THE BROAD INSTITUTE, INC.
    Inventors: Chris Dockendorff, Robert Flaumenhaft, Lawrence MacPherson
  • Sonic hedgehog modulators
    Patent number: 8530456
    Abstract: The present invention relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: September 10, 2013
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Lee F. Peng, Julia Lamenzo, Nicole Maloof, Kazuo Nakai, Benjamin Stanton, Sara Jean Buhrlage, Lawrence MacPherson, Michel Weiwer, Stuart L. Schreiber
  • SONIC HEDGEHOG MODULATORS
    Publication number: 20110172233
    Abstract: The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.
    Type: Application
    Filed: April 21, 2009
    Publication date: July 14, 2011
    Inventors: Lee F. Peng, Julia Lamenzo, Nicole Maloof, Kazuo Nakai, Benjamin Stanton, Sara Jean, Lawrence Macpherson, Michel Weiwer, Stuart L. Schreiber
  • Fused heterocycles as inhibitors of glutamate racemase(MURI)
    Patent number: 7371757
    Abstract: This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: May 13, 2008
    Assignee: AstraZeneca AB
    Inventors: Marshall Morningstar, Gregory Basarab, Charles Joseph Eyermann, Madhu Gowravaram, Oluyinka Green, Andrew Kiely, Lawrence MacPherson, Nguyen Thanh
  • Novel Fused Heterocycles and Uses Thereof
    Publication number: 20070275954
    Abstract: This invention relates to novel compounds having the Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 29, 2007
    Applicant: AstraZeneca AB
    Inventors: Gregory Basarab, Charles Eyermann, Bolin Geng, Madhusudhan Gowravaram, James Loch III, Lawrence MacPherson, Marshall Morningstar, George Mullen, Alex Staz, Andrew Kiely
  • Pyrazolo[3,4-d]pyrimidines inhibiting infections
    Patent number: 7285558
    Abstract: Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: October 23, 2007
    Assignee: AstraZeneca AB
    Inventors: Gregory Basarab, Joseph Eyermann, Madhusudhan Gowravaram, Oluyinka Green, Lawrence MacPherson, Marshall Morningstar, Thanh Nguyen
  • Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection
    Publication number: 20070004761
    Abstract: This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 4, 2007
    Inventors: Gregory Basarab, Joseph Eyermann, Madhusudhan Gowravaram, Ohryinka Green, Lawrence MacPherson, Marshall Morningstar, Thanh Nguyen
  • Fused heterocycles as inhibitors of glutamate racemase(muri)
    Publication number: 20060252781
    Abstract: This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
    Type: Application
    Filed: August 12, 2004
    Publication date: November 9, 2006
    Inventors: Gregory Basarab, Charles Eyermann, Madhusudhhan Gowravaram, Oluyinka Green, Andrew Kiely, Lawrence Macpherson, Marshall Morningstar, Nguyen Thanh
  • Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections
    Publication number: 20040254183
    Abstract: Compounds having the general formula 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 16, 2004
    Inventors: Gregory Basarab, Joseph Eyermann, Madhusudhan Gowravaram, Oluyinka Green, Lawrence MacPherson, Marshall Morningstar, Thanh Nguyen