Patents by Inventor Lawrence Mark Mielnicki

Lawrence Mark Mielnicki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput assay for identification of gene expression modifiers
    Patent number: 7083919
    Abstract: The present invention provides a method for screening of a large number of compounds for their ability to modulate the expression of genes. The method uses gene trap technology and comprises the steps of transfecting a population of cells with a gene-trap vector, sorting cells according to their level of fluorescence, distributing sorted cells into pools and expanding the pools to obtain a sufficient number of cells representing each trapped gene to permit distinction of the effect of a test compound over controls, exposing the cells to the test compounds and identifying compounds which alter the fluorescence distribution pattern of cells using FACS analysis.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: August 1, 2006
    Assignee: The Research Foundation of State University of New York
    Inventors: Steven C. Pruitt, David G. Hangauer, Carleton C. Stewart, Lawrence Mark Mielnicki
  • High throughput assay for identification of gene expression modifiers
    Publication number: 20020164636
    Abstract: The present invention provides a method for screening of a large number of compounds for their ability to modulate the expression of genes. The method uses gene trap technology and comprises the steps of transfecting a population of cells with a gene-trap vector, sorting cells according to their level of fluorescence, distributing sorted cells into pools and expanding the pools to obtain a sufficient number of cells representing each trapped gene to permit distinction of the effect of a test compound over controls, exposing the cells to the test compounds and identifying compounds which alter the fluorescence distribution pattern of cells using FACS analysis.
    Type: Application
    Filed: May 6, 2002
    Publication date: November 7, 2002
    Inventors: Steven C. Pruitt, David G. Hangauer, Carleton C. Stewart, Lawrence Mark Mielnicki