Abstract: The present invention is particularly directed to the use of a derivative of vinblastine, 3',4'-anhydrovinblastine (AHVB), which differs from vinblastine in that it possesses a double bond at the 3',4' position of the caranthine nucleus rather than the hydroxyl group that is present in the parent structure, as an antineoplastic agent in the therapeutic treatment of cancer. Specifically, the treatment of lymphoma with 3',4'-anhydrovinblastine is disclosed.

Abstract: A portfolio includes a rectangular piece of a canvas material having an outer peripheral edge, a rectangular peripheral piece of a vinyl material having an inner peripheral edge that slightly overlaps the outer peripheral edge of the canvas material, with an inner surface of the inner peripheral edge and an outer surface of the outer peripheral edge being heat sealed to each other with a predetermined stitching pattern, a first cardboard rigidifying member positioned to an inner surface of the canvas material corresponding to a top panel of the desk folder, a second cardboard rigidifying member positioned to an inner surface of the canvas material adjacent to the first rigidifying member, corresponding to a bottom panel of the desk folder, with a spacing between the first and second rigidifying members which defines a narrow binding edge which connects together side edges of the top and bottom panels, a vinyl backing member positioned over the first and second rigidifying members being heat sealed to the viny