Abstract: An apparatus, and related method, for determining one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module. The program module is stored in the memory and is configurable to be executed by the processor. The program module includes instructions for determining a statistical relationship between one or more temporal onsets corresponding to one or more events and a pattern of occurrence of a compound variable. The compound variable corresponds at least to a pattern of occurrence of a first variable and a pattern of occurrence of a second variable. The determining includes contributions from presence and absence information in the pattern of occurrence of the compound variable.

Abstract: Methods and compositions, e.g., kits, are provided for treating a host suffering from an indomethacin responsive headache syndrome. In the subject methods, a topical indomethacin formulation is applied to a keratinized skin site proximal to the pain associated with the headache syndrome, e.g. a keratinized skin surface of the head, such as the forehead, temple, etc. Practice of the subject methods results in at least a reduction in the intensity of the pain associated with the syndrome. The subject methods and compositions find use in the treatment of a variety of indomethacin responsive headache syndromes, including syndromes that are absolutely responsive to indomethacin therapy and syndromes that are variably responsive to indomethacin therapy.