Patents by Inventor Lawrence Pfeffer

Lawrence Pfeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINED TARGETING OF STAT3 AND ULKI TO TREAT GLIOBLASTOMA
    Publication number: 20250011790
    Abstract: Disclosed herein is a composition comprising a signal transducer and activator of transcription 3 (STAT3) inhibitor and one or more of a UNC51-like 1 (ULK1) inhibitor, histone deacetylase (HDAC) inhibitor, or an mTOR inhibitor in a pharmaceutically acceptable carrier. Also disclosed is a method for treating glioblastoma in a subject that involves administering to the subject an effective amount of a STAT3 inhibitor and one or more of a ULK inhibitor, an AMPK? inhibitor, an HDAC inhibitor, or an mTOR inhibitor.
    Type: Application
    Filed: November 11, 2022
    Publication date: January 9, 2025
    Inventors: Edward CHAUM, Sujoy BHATTACHARYA, Lawrence PFEFFER
  • BENZYLTHIOPHENE DERIVATIVES
    Publication number: 20240368112
    Abstract: Disclosed are benzylthiophene derivatives, pharmaceutical compositions comprising them, and methods of using them.
    Type: Application
    Filed: September 16, 2022
    Publication date: November 7, 2024
    Inventors: John K. Buolamwini, Mithun Raje, Hemantkumar Deokar, Lawrence Pfeffer, James Turkson
  • BROMODOMAIN INHIBITORS FOR CANCER THERAPY
    Publication number: 20240316043
    Abstract: The present disclosure related to compounds of Formula (I): stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, including to treat cancer in a subject.
    Type: Application
    Filed: March 21, 2024
    Publication date: September 26, 2024
    Applicant: University of Tennessee Research Foundation
    Inventors: Duane Miller, Lawrence Pfeffer, Yali He, Yinan Wang, Chuan Yang
  • INTERFERON GENE SIGNATURE AND METHODS OF USE THEREOF
    Publication number: 20130261018
    Abstract: The present invention is a method and kit for determining responsiveness of a subject to treatment with a Type I interferon based upon the expression of gene signatures shown to be stimulated by interferon. A method for testing the propensity of a test compound to induce a Type I interferon response is also provided.
    Type: Application
    Filed: October 13, 2011
    Publication date: October 3, 2013
    Applicant: University of Tennessee Research Foundation
    Inventors: Lawrence Pfeffer, Meiyun Fan, Susan R. Pfeffer, Charles Handorf