Patents by Inventor Lawrence S. Mathews

Lawrence S. Mathews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to activin receptor
    Patent number: 7893213
    Abstract: In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-? superfamily of polypeptide growth factors such that concentrations of ?10 nM of said polypeptide growth factor occupy ?50% of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-?, and other non-activin-like proteins.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: February 22, 2011
    Assignee: The Salk Institute for Biological Studies
    Inventors: Lawrence S. Mathews, Wylie W. Vale, Jr., Kunihiro Tsuchida
  • CLONING AND RECOMBINANT PRODUCTION OF RECEPTOR(S) OF THE ACTIVIN/TGF-BETA SUPERFAMILY
    Publication number: 20100016558
    Abstract: In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-? superfamily of polypeptide growth factors such that concentrations of ?10 nM of said polypeptide growth factor occupy ?50% of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-?, and other non-activin-like proteins.
    Type: Application
    Filed: May 11, 2007
    Publication date: January 21, 2010
    Inventors: Lawrence S. Mathews, Wylie W. Vale, JR., Kunihiro Tsuchida
  • Cloning and recombinant production of receptor(s) of the activin/TGF-beta superfamily
    Publication number: 20010039036
    Abstract: In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein:
    Type: Application
    Filed: December 19, 2000
    Publication date: November 8, 2001
    Applicant: The Salk Institute for Biological Studies.
    Inventors: Lawrence S. Mathews, Wylie W. Vale, Kunihiro Tsuchida
  • Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-.beta. superfamily
    Patent number: 5885794
    Abstract: In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein:an extracellular, ligand-binding domain,a hydrophobic, trans-membrane domain, andan intracellular, receptor domain having serine kinase-like activity.The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-.beta. superfamily of polypeptide growth factors such that concentrations of .ltoreq.10 nM of said polypeptide growth factor occupy .gtoreq.50% of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-.beta., and other non-activin-like proteins.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: March 23, 1999
    Assignee: The Salk Institute for Biological Studies
    Inventors: Lawrence S. Mathews, Wylie W. Vale