Patents by Inventor Lawrence Shapiro

Lawrence Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11321668
    Abstract: A method for codeless development of an application includes registering one or more actions in a registry. Each action is coded in a reusable block of code, each action having an action definition including an action type name, an input parameters map, and an output parameters map. The method further includes performing an action type name look up in the registry for an invoked action with an action service ensuring that a number of arguments included in the action definition matches a number of arguments specified by the action type, passing an input to and receiving a return value from the invoked action, updating the output parameters map included in the definition of the invoked action, and returning the updated output parameters map to an application in development for updating processing variables in the application.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: May 3, 2022
    Assignee: BMC Software, Inc.
    Inventors: Abhijit Anirrudha Rajwade, Steve Wong, David Lawrence Shapiro, Jiayi Gu, Girish Kumar Gupta, David T. Sulcer
  • Publication number: 20220098286
    Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
    Type: Application
    Filed: December 14, 2021
    Publication date: March 31, 2022
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Trustees of Columbia University in the City of New York
    Inventors: Peter Kwong, Young Do Kwon, Ivelin Georgiev, Gilad Ofek, Baoshan Zhang, Krisha McKee, John Mascola, Mark Connors, Gwo-Yu Chuang, Sijy O'Dell, Robert Bailer, Mark Louder, Mangaiarkarasi Asokan, Richard Schwartz, Jonathan Cooper, Kevin Carlton, Michael Bender, Amarendra Pegu, Lawrence Shapiro, Tatyana Gindin, Lisa Kueltzo
  • Patent number: 11236152
    Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: February 1, 2022
    Assignees: The United States of America, as represented by the Sectetary, Department of Health and Human Services, The Trustees of Columbia University in the City of New York
    Inventors: Peter Kwong, Young Do Kwon, Ivelin Georgiev, Gilad Ofek, Baoshan Zhang, Krisha McKee, John Mascola, Mark Connors, Gwo-Yu Chuang, Sijy O'Dell, Robert Bailer, Mark Louder, Mangaiarkarasi Asokan, Richard Schwartz, Jonathan Cooper, Kevin Carlton, Michael Bender, Amarendra Pegu, Lawrence Shapiro, Tatyana Gindin, Lisa Kueltzo
  • Publication number: 20200057995
    Abstract: A method for codeless development of an application includes registering one or more actions in a registry. Each action is coded in a reusable block of code, each action having an action definition including an action type name, an input parameters map, and an output parameters map. The method further includes performing an action type name look up in the registry for an invoked action with an action service ensuring that a number of arguments included in the action definition matches a number of arguments specified by the action type, passing an input to and receiving a return value from the invoked action, updating the output parameters map included in the definition of the invoked action, and returning the updated output parameters map to an application in development for updating processing variables in the application.
    Type: Application
    Filed: October 28, 2019
    Publication date: February 20, 2020
    Inventors: Abhijit Anirrudha Rajwade, Steve Wong, David Lawrence Shapiro, Jiayi Gu, Girish Kumar Gupta, David T. Sulcer
  • Patent number: 10504064
    Abstract: In one general aspect, a method can include creating an action, the creating including annotating a block of code with metadata, and encapsulating the annotated block of code into a reusable building block of code. The method can further include publishing the action, the publishing including registering the action in a service registry. The method can further include dynamically discovering the action in the service registry by an application during runtime, invoking the action by the application, and executing the action by the application, the executing performing a method specified by the action.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: December 10, 2019
    Assignee: BMC Software, Inc.
    Inventors: Abhijit Anirrudha Rajwade, Steve Wong, David Lawrence Shapiro, Jiayi Gu, Girish Kumar Gupta, David T. Sulcer
  • Publication number: 20190077849
    Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
    Type: Application
    Filed: November 3, 2016
    Publication date: March 14, 2019
    Applicants: The Trustees of Columbia University in the City of New York, The United States of AMerica, as represented by the Secretary, Department of Health and Human Serc
    Inventors: Peter Kwong, Young Do Kwon, Ivelin Georgiev, Gilad Ofek, Baoshan Zhang, Krisha McKee, John Mascola, Mark Connors, Gwo-Yu Chuang, Sijy O'Dell, Robert Bailer, Mark Louder, Mangaiarkarasi Asokan, Richard Schwartz, Jonathan Cooper, Kevin Carlton, Michael Bender, Amarendra Pegu, Lawrence Shapiro, Tatyana Gindin, Lisa Kueltzo
  • Publication number: 20170053243
    Abstract: In one general aspect, a method can include creating an action, the creating including annotating a block of code with metadata, and encapsulating the annotated block of code into a reusable building block of code. The method can further include publishing the action, the publishing including registering the action in a service registry. The method can further include dynamically discovering the action in the service registry by an application during runtime, invoking the action by the application, and executing the action by the application, the executing performing a method specified by the action.
    Type: Application
    Filed: August 31, 2015
    Publication date: February 23, 2017
    Inventors: Abhijit Anirrudha RAJWADE, Steve WONG, David Lawrence SHAPIRO, Jiayi GU, Girish Kumar GUPTA, David T. SULCER
  • Publication number: 20120282264
    Abstract: Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
    Type: Application
    Filed: September 24, 2010
    Publication date: November 8, 2012
    Inventors: John R. Mascola, Richard Wyatt, Xueling Wu, Yuxing Li, Carl-Magnus Hogerkorp, Mario Roederer, Zhi-yong Yang, Gary Nabel, Peter Kwong, Tongqing Zhou, Mark Connors, Gilad Ofek, Lawrence Shapiro, Jiang Zhu, William R. Schief
  • Publication number: 20120244166
    Abstract: Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and uses of these antibodies, are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 27, 2012
    Inventors: John R. Mascola, Richard T. Wyatt, Xueling Wu, Yuxing Li, Carl-Magnus Hogerkorp, Mario Roederer, Zhi-yong Yang, Gary J. Nabel, Peter D. Kwong, Tongqing Zhou, Mark Connors, Gilad Ofek, Lawrence Shapiro, Jiang Zhu, William R. Schief
  • Publication number: 20120237523
    Abstract: Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 20, 2012
    Inventors: John R. Mascola, Richard T. Wyatt, Xueling Wu, Yuxing Li, Carl-Magnus Hogerkorp, Mario Roederer, Zhi-yong Yang, Gary J. Nabel, Peter D. Kwong, Tongqing Zhou, Mark Connors, Gilad Ofek, Lawrence Shapiro, Jiang Zhu, William R. Schief
  • Patent number: 7152385
    Abstract: Methods, systems, and devices for installing barriers in openings of gaps in or between structures such as walls, ceilings, and floors are described herein. At least one barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is preferably operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to create a barrier in the hole or gap.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: December 26, 2006
    Assignee: W.R. Grace & Co.-Conn.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Jr., Leon Bablouzian, Lawrence Shapiro, William J. Hurley, Jr.
  • Publication number: 20060101785
    Abstract: A building element having pressure-sensitive adhesive coating layer having a low initial bond strength, to permit a substrate to be repositioned without destroying the integrity of the adhesive, and a long term bond strength, which occurs after the building element is mechanically fastened to another building element. This allows wood deck components, flooring planks, roofing tiles, and other building material components to be fastened together conveniently while securing a waterproofing and/or sound-deadening effect.
    Type: Application
    Filed: October 25, 2005
    Publication date: May 18, 2006
    Inventors: Robert Wiercinski, Lawrence Shapiro
  • Patent number: 7043880
    Abstract: The invention provides methods, systems, and devices for installing thermal barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one thermal barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to mold a barrier in the hole or gap.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: May 16, 2006
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Jr., Leon Bablouzian, Lawrence Shapiro, William J. Hurley, Jr.
  • Publication number: 20060059825
    Abstract: Methods and structures involving the use of a double-sided adhesive membrane assembly having one adhesive surface with low initial tackiness to permit a substrate to be re-positionable even if pressed into contact against the adhesive. The method allows wood deck components, flooring planks, roofing tiles, and other building material components to be fastened together conveniently while securing a waterproofing and/or sound-deadening effect.
    Type: Application
    Filed: August 1, 2005
    Publication date: March 23, 2006
    Inventors: Robert Wiercinski, Lawrence Shapiro, Robert Sorrentino
  • Publication number: 20050126109
    Abstract: Exemplary methods and assemblies for preventing corrosion of metal connector devices, e.g., zinc-galvanized joist hangers and fasteners, used for assembling outdoor structures such as decks from wood components pretreated with alkaline copper quat (ACQ), ammoniacal copper quat (ACQ-B), copper azole (CA), or mixtures thereof. Membrane barriers separate metal from wood, and seal around fasteners thus minimizing corrosion of the connector devices and fasteners.
    Type: Application
    Filed: December 15, 2003
    Publication date: June 16, 2005
    Inventors: Antonio Aldykiewicz, Gerald Blay, Gregory Ciampa, Ann Jansen, Edwin Schaughency, Lawrence Shapiro, Albina Velikin, Walter Wydra
  • Patent number: 6783345
    Abstract: The invention provides methods, systems, and devices for installing barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is preferably operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to create a barrier in the hole or gap.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: August 31, 2004
    Assignee: W.R. Grace & Co.-Conn
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Jr., Leon Bablouzian, Lawrence Shapiro, William J. Hurley, Jr.
  • Publication number: 20040045234
    Abstract: The invention provides methods, systems, and devices for installing barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is preferably operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to create a barrier in the hole or gap.
    Type: Application
    Filed: September 4, 2003
    Publication date: March 11, 2004
    Applicant: W.R. GRACE & CO.-CONN.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Leon Bablouzian, Lawrence Shapiro, William J. Hurley
  • Patent number: 6698146
    Abstract: The invention provides methods, systems, and devices for installing thermal barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one thermal barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to mold a barrier in the hole or gap.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: March 2, 2004
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Jr., Leon Bablouzian, Lawrence Shapiro
  • Publication number: 20030213211
    Abstract: The invention provides methods, systems, and devices for installing thermal barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one thermal barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to mold a barrier in the hole or gap.
    Type: Application
    Filed: April 15, 2003
    Publication date: November 20, 2003
    Applicant: W.R. GRACE & CO.-CONN.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Leon Bablouzian, Lawrence Shapiro, William J. Hurley
  • Publication number: 20030089062
    Abstract: The invention provides methods, systems, and devices for installing barriers in openings or gaps in or between structures such as walls, ceilings, and floors. At least one barrier molding bag is positioned in the hole or gap, and a flowable firestop material that is preferably operative to cure or harden, such as a hydratable cementitious slurry, is introduced into the bag to create a barrier in the hole or gap.
    Type: Application
    Filed: May 20, 2002
    Publication date: May 15, 2003
    Applicant: W.R. GRACE & CO.-CONN.
    Inventors: Michael D. Morgan, Xiudong Sun, Laura A. Tennenhouse, Robert A. Wiercinski, Benita Dair, Antonio J. Aldykiewicz, Leon Bablouzian, Lawrence Shapiro, William J. Hurley