Abstract: Chimeric antigen receptor molecules that include a variant IL-13. The variant IL-13 are more selective for IL13R?2 than IL13R?1 by virtue of weaker binding to IL13R?1. The chimeric antigen receptors can be used to treat IL13R?2 expressing cancers.

Abstract: CD19 scFv, methods for using such scFv, CAR that include such scFv, methods for making and using such CD19 targeted CAR T cells and CD19 targeted CAR natural killer (NK) cells are described as a methods to treat a variety of cancers.

Abstract: Chimeric antigen receptor molecules that include a variant IL-13. The variant IL-13 are more selective for IL13R?2 than IL13R?1 by virtue of weaker binding to IL13R?1. The chimeric antigen receptors can be used to treat IL13R?2 expressing cancers.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: Chimeric antigen receptor molecules that include a variant IL-13. The variant IL-13 are more selective for IL13R?2 than IL13R?1 by virtue of weaker binding to IL13R?1. The chimeric antigen receptors can be used to treat IL13R?2 expressing cancers.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: A method of improving the landing of a hydraulic elevator car which responds to slowdown and leveling indicia associated with each floor of a building served by the car. The method, which utilizes signals which are already generated relative to the car traveling past slowdown and leveling indicia, provides an optimum deceleration time TOPT for the car to initiate deceleration and arrive at a leveling zone of a target floor, defined by leveling indicia. The method further delays the initiation of deceleration of the car, after the car reaches slowdown indicia for the target floor, by a predetermined time delay Td. The method determines the actual time TACT for the car to travel between slowdown and leveling indicia for the target floor, and then changes Td, if necessary, in a direction which tends to optimize Td, when TACT - Td is not equal to TOPT.

Abstract: A hypodermic syringe has a needle guard of elliptical cross section which is releasable by compressing the needle guard along its major axis, and, which can be moved between an extended and a retracted position when released. Optionally, a compression spring is provided for urging the needle guard towards an extended position.

Abstract: A double-faced blister pack and frame assembly for packaging and displaying an article of merchandise. The article is sandwiched between a pair of superposed, transparent plastic sheets whose central regions are molded to generally conform to the opposite faces of the article, the four superposed margins of the sheets each defining a flange. The frame is formed of a cardboard strip that is so die-cut and folded as to create a chain of four interhinged branches each having a triangular truss cross section whose base chord is the outer wall of the frame and whose central strut is constituted by parallel walls extending from the apex of the triangle to the base chord to form a narrow slot. Socketed in the slot of each branch is the corresponding flange of the pack whereby the pack is supported by the frame, and the opposite faces of the article which lie within the frame are both exposed to a prospective purchaser who is able to fully examine the article without having to break open the package to do so.

Abstract: A hydraulic elevator system having a tunnel member as part of the car frame, to reduce the pit depth required for a hydraulic jack. A stabilizer for the plunger of the hydraulic jack is fixed to the bottom of the tunnel member, with the stabilizer being in an inactive, retracted position while the cylinder head is within the tunnel member. The stabilizer is automatically actuated to an operative plunger support position, as the elevator car rises and the bottom of the tunnel member starts to rise higher than the cylinder head, to provide an additional lateral support point for the plunger. The lateral support function provided by the stabilizer functions at all times, in both the active and inactive positions, without any wear inducing relative motion between the stabilizing surfaces of the stabilizer, and any other element of the system, including the hydraulic jack, its plunger, or the tunnel of the car frame.