Abstract: This disclosure pertains to compounds, the preparation thereof, and the use of these compounds in the treatment of prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in subjects in need thereof.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: A vehicle detection system warns snowmobilers of other approaching vehicles with potential risk of collision. To better prevent accidents, the system calculates collision risks and warns the rider based on level of risk. When riding in groups, a member can press a stop request button to ask the group to slow down. When a member exits the group, everyone in the group will receive a message, alerts or indication with the update. The vehicle detection system utilizes Bluetooth® low energy (BLE), LoRaWAN® technologies and/or global positioning system technologies and is designed to detect other devices in the region and use acquired information to calculate proximity and risk of collision.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: Semiconductor devices and methods of forming the same include a front-end-of-line (FEOL) layer that includes a first transistor device. A first back-end-of-line (BEOL) layer is on a front side of the FEOL layer and includes a first electrical connection to the first transistor device. A second BEOL layer is on a back side of the FEOL layer and includes a first BEOL device with a second electrical connection to the first transistor device.

Abstract: Systems and methods include the following. Information about a first electronic communication device is transmitted to at least one server and/or decentralized infrastructure. The information includes vicinity information. A status signal associated with a first user of the first electronic communication device is optionally transmitted. Contact proximity network information about a contact proximity network is received. The contact proximity network is based on the information from a plurality of electronic communication devices and information about the association between users and electronic communication devices. The contact proximity network information includes status signal information and interconnected nodes corresponding to different users and pairwise connections between users based upon their relative physical space and time proximity.

Abstract: Systems and methods include the following. Information about a first electronic communication device is transmitted to at least one server and/or decentralized infrastructure. The information includes vicinity information. A status signal associated with a first user of the first electronic communication device is optionally transmitted. Contact proximity network information about a contact proximity network is received. The contact proximity network is based on the information from a plurality of electronic communication devices and information about the association between users and electronic communication devices. The contact proximity network information includes status signal information and interconnected nodes corresponding to different users and pairwise connections between users based upon their relative physical space and time proximity.

Abstract: A system and method of controlling a powertrain to protect a high voltage cable by determining a temperature characteristic for a busbar, determining a temperature characteristic adjacent to a component, and determining a current through the high voltage cable. Thereafter, the method reduces an operating characteristic of the powertrain based on the temperature characteristic for the busbar, the temperature characteristic adjacent to the component, and the current.

Abstract: Systems, methods, and non-transitory computer-readable media can obtain data associated with a computer-based experience. The computer-based experience can be based on interactive real-time technology. At least one virtual camera can be configured within the computer-based experience in a real-time engine. Data associated with an edit cut of the computer-based experience can be obtained based on content captured by the at least one virtual camera. A plurality of shots that correspond to two-dimensional content can be generated from the edit cut of the computer-based experience in the real-time engine. Data associated with a two-dimensional version of the computer-based experience can be generated with the real-time engine based on the plurality of shots. The two-dimensional version can be rendered based on the generated data.

Abstract: In a wavelength selective switch, an input port transmits an input beam, and diffraction grating disperses the input beam into optical channels. A liquid-crystal-on-silicon (LCoS) switch assembly has a phase grating profile and has addressable pixels, which are liquid crystal based. The LCoS switch assembly can selectively direct first-order diffracted beams of the optical channels for output to selected output ports. A tunable optical wedge adjacent the LCoS switch assembly can direct higher-order diffraction beams in the space between the output ports to reduce crosstalk. The wedge is a liquid crystal cell having spaced-apart resistive layers and having liquid crystal material disposed between the layers. In the wedge, the liquid crystal material can produce a phase profile in response to bias voltages applied to the resistive layers, and a beam steering angle of the phase profile can direct at least the second-order diffracted beams towards the port spacing between the ports.

Abstract: Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

Abstract: Systems and methods include the following. Information about a first electronic communication device is transmitted to at least one server and/or decentralized infrastructure. The information includes vicinity information. A status signal associated with a first user of the first electronic communication device is optionally transmitted. Contact proximity network information about a contact proximity network is received. The contact proximity network is based on the information from a plurality of electronic communication devices and information about the association between users and electronic communication devices. The contact proximity network information includes status signal information and interconnected nodes corresponding to different users and pairwise connections between users based upon their relative physical space and time proximity.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: A multiple wavelength selective switch has an optics assembly to receive a first input optical signal from a first ingress port and a second input optical signal from a second ingress port. A switch assembly has a single switching mechanism to direct the first input optical signal to the optics assembly as a first output optical signal and the second input optical signal to the optics assembly as a second output optical signal. The switch assembly directs the first output optical signal to a first egress port selected from the first set of egress ports and directs the second output optical signal to a second egress port selected from the second set egress ports. The first egress port and the second egress port have the same wavelength channel. The multiple wavelength selective switch supports an arbitrary number of wavelength channels that can be switched at the same time. Each switch assembly directs signals from a set of ingress ports to a set of egress ports sharing the same wavelength channel.

Abstract: An electromechanical polymer (EMP) sensor includes (a) a first set of EMP layers provided between a first electrode and a second electrode forming a capacitor, the first set of EMP layers having one or more EMP layers capable of being activated by application of a voltage across the first and second electrodes; and (b) a sensing circuit coupled to the first electrode and the second electrode for detecting a change in capacitance or a change in voltage across the first and second electrodes. The EMP sensor may further include means for disconnecting the second electrode from a ground reference after the pre-determined voltage is applied, such that the sensing circuit senses a change in capacitance. The sensing circuit may be capable of detecting a noise portion of a voltage across the first and second electrode.

Abstract: LED lighting systems employing plano optics, direct dissipation heat sinks, and linear AC direct current drivers are disclosed. The heat sink is configured to provide thermal management for the LED lights and AC linear current driver circuit elements, as well as to provide a means for holding lenses having diffractive optical elements. The LED lighting systems are compact, energy efficient, and may be used in many conventional incandescent or fluorescent lighting applications. Lenses having diffractive optical elements are designed to redirect light radiated from the LEDs into other directions.

Abstract: An interactive entertainment system comprises a display device for viewing an interactive video and a controller for operating one or more sex toys for providing stimulations to a user at a remote location and displayed in the interactive video. A sensory feedback is generated as a function of the provide stimulations. The sensory feedback indicates one or more of the following: strength of the stimulations; patterns of the stimulations; characteristics of the stimulations; status of the stimulations; types of the stimulations; and the status of the sex toys. The one or more sex toys and the controller are at different locations. The one or more sex toys can be virtual objects or real objects, while the user can be a virtual user or a natural person.

Abstract: An electromechanical polymer (EMP) sensor includes (a) a first set of EMP layers provided between a first electrode and a second electrode forming a capacitor, the first set of EMP layers having one or more EMP layers capable of being activated by application of a voltage across the first and second electrodes; and (b) a sensing circuit coupled to the first electrode and the second electrode for detecting a change in capacitance or a change in voltage across the first and second electrodes. The EMP sensor may further include means for disconnecting the second electrode from a ground reference after the pre-determined voltage is applied, such that the sensing circuit senses a change in capacitance. The sensing circuit may be capable of detecting a noise portion of a voltage across the first and second electrode.

Abstract: A system and method for managing application provisioning to one or more wireless devices are disclosed. In a preferred embodiment, the system comprises a server framework that is adapted to communicate with one or more wireless devices of various types via a wireless communications network. An administration tool is preferably provided that permits an administrator to specify whether an application is required, optional, or unauthorized for individual users or user groups and whether an application is compatible with a specific type of user device. When a user attempts to log into the server framework from his or her wireless device, the system automatically downloads all compatible required applications to the user's device and deletes all unauthorized downloaded applications from the user's device. It also gives the user the opportunity to download any optional applications that are compatible with the user's device.