Patents by Inventor Lawrence Weissbach

Lawrence Weissbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MMP-2 propeptide for use as antiangiogenic or antitumor agent
    Publication number: 20020151481
    Abstract: Methods and compositions for inhibiting growth of a tumor, inhibiting angiogenesis and inhibiting extracellular matrix destruction in a mammal are disclosed. The method includes administering a therapeutically effective amount of a polypeptide that contains the sequence ProArgCysGlyXaaProAsp, wherein Xaa represents Val or Asn (SEQ ID NO:6). Preferably, the polypeptide is 60 to 100 amino acids in length. In some embodiments, the polypeptide is a human MMP-2 propeptide (SEQ ID NO:1) or an MMP-2 propeptide-like polypeptide, i.e., a polypeptide having at least 80% sequence identity with SEQ ID NO:1.
    Type: Application
    Filed: April 12, 2001
    Publication date: October 17, 2002
    Inventor: Lawrence Weissbach
  • Plasminogen-related gene B Polypeptides
    Publication number: 20020151482
    Abstract: A method of inhibiting angiogenesis or neoplastic growth, or both, in a bird or mammal is disclosed. The method involves identifying an animal that has, or is at risk for, unwanted angiogenesis or neoplastic growth or both, and administering to the animal an amount of a plasminogen-related gene-B polypeptide sufficient to inhibit the angiogenesis or neoplastic growth.
    Type: Application
    Filed: May 7, 2001
    Publication date: October 17, 2002
    Inventors: Lawrence Weissbach, Valerae Lewis, Michael O'Reilly
  • Gap-related gene, human IQGAP1
    Patent number: 5639651
    Abstract: A purified nucleic acid encoding the IQGAP1 protein, a novel member of the GTPase activating protein family, useful in the diagnosis and treatment of tumors.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: June 17, 1997
    Assignee: The General Hospital Corporation
    Inventors: Lawrence Weissbach, Andre Bernards, Jeffrey Settleman
  • Plasmilar and plasmilar antibody compositions as malignant cell markers
    Patent number: 5545717
    Abstract: Disclosed are substantially pure plasmilar polypeptide and antibodies which bind plasmilar.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: August 13, 1996
    Assignee: The General Hospital Corporation
    Inventor: Lawrence Weissbach