Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.

Abstract: A monoplace hyperbaric chamber design to permit at least 2 ATR (about 30 psi relative) internal pressure which accommodates upright seating and, with stiffeners removed for transport, has dimensions to facilitate the chamber passing through a common door opening width of a doctor's examination room where the stiffeners are attached without disturbing a hermetic seal of the hyperbaric chamber.

Abstract: A hybrid tree and network visualization represents a segmented computer network. The visualization presents an overview of the segmentation as a hierarchy and displays connections within the network. Using the visualization, analysts can explore a segmented network, identify nodes and connections of interest through exploratory network analysis, and drill down on elements of interest to reason about the patterns of relationships in the network. Thus, analysts can intuitively obtain a deeper understanding of the network to identify potential security threats and other problems as well as write better segmentation policies.

Abstract: Compounds that selectively inhibit GluN2B-containing N-methyl-D-aspartic acid receptors (NMDARs) are disclosed. In some cases, the compounds selectively target GluN2B over GluN2A, GluN2C, and/or GluN2D. Generally, the compounds possess an enhanced potency to GluN2B at a pH that is more acidic compared to the physiological pH. Pharmaceutical formulations containing one or more of the compounds are also disclosed. Additionally, methods of treating a condition, disorder or disease using the compounds or their pharmaceutical formulations thereof are disclosed.

Abstract: CXCR4 antagonists and pharmaceutical formulations thereof are disclosed. The compounds and pharmaceutical formulations disclosed herein can be used to antagonize the CXCR4 pathway for mobilizing stem cells or treating a condition, disorder, or disease associated with the CXCR4 pathway. Exemplary conditions, disorders, and diseases relevant to this disclosure include HIV infections, WHIM syndrome, Waldenström macroglobulinemia, chronic neutropenia, primary immune-deficiency, aplastic anemia, hypoplastic myelodysplastic syndrome, acute respiratory distress syndrome (ARDS), ankylosing spondylitis, autoimmune diseases, and cancers.

Abstract: Compounds that selectively inhibit GluN2B-containing N-methyl-D-aspartic acid receptors (NMDARs) are disclosed. In some cases, the compounds selectively target GluN2B over GluN2A, GluN2C, and/or GluN2D. Generally, the compounds possess an enhanced potency to GluN2B at a pH that is more acidic compared to the physiological pH. Pharmaceutical formulations containing one or more of the compounds are also disclosed. Additionally, methods of treating a condition, disorder or disease using the compounds or their pharmaceutical formulations thereof are disclosed.

Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

Abstract: A hybrid tree and network visualization represents a segmented computer network. The visualization presents an overview of the segmentation as a hierarchy and displays connections within the network. Using the visualization, analysts can explore a segmented network, identify nodes and connections of interest through exploratory network analysis, and drill down on elements of interest to reason about the patterns of relationships in the network. Thus, analysts can intuitively obtain a deeper understanding of the network to identify potential security threats and other problems as well as write better segmentation policies.

Abstract: This disclsore relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.

Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.

Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

Abstract: The present invention provides a system and a method for performing electromagnetic compatibility measurements. A signal source generates a test signal which is amplified by an amplifier. Overdriving of the amplifier is prevented by limiting the test signal applied to the amplifier below a predefined threshold value.

Abstract: The present invention provides a system and a method for performing electromagnetic compatibility measurements. A signal source generates a test signal which is amplified by an amplifier. Overdriving of the amplifier is prevented by limiting the test signal applied to the amplifier below a predefined threshold value.

Abstract: A support system for assembling and shipping a steam turbine is provided that includes an annular support fixture configured to be coupled to a longitudinal end of a casing of the steam turbine. The annular support fixture includes a first protrusion that extends in an axial direction relative to a longitudinal axis of a rotor of the steam turbine between the rotor and the casing and that is configured to support the rotor in the radial direction. The annular support fixture includes a second protrusion, which extends in the radial direction toward a lateral surface of the rotor and which includes a surface configured to face the rotor in the axial direction. The support system includes a block configured to be disposed between the surface of the second protrusion and the rotor, such that the block blocks movement of the rotor in the axial direction during shipping of the steam turbine.

Abstract: A support system for assembling and shipping a steam turbine is provided that includes an annular support fixture configured to be coupled to a longitudinal end of a casing of the steam turbine. The annular support fixture includes a first protrusion that extends in an axial direction relative to a longitudinal axis of a rotor of the steam turbine between the rotor and the casing and that is configured to support the rotor in the radial direction. The annular support fixture includes a second protrusion, which extends in the radial direction toward a lateral surface of the rotor and which includes a surface configured to face the rotor in the axial direction. The support system includes a block configured to be disposed between the surface of the second protrusion and the rotor, such that the block blocks movement of the rotor in the axial direction during shipping of the steam turbine.

Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.

Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

Abstract: A computer acting as display device can present pixmap screen page image(s), and with end-user input, can act on associated interaction(s) area(s) specification(s); with the screen page image(s) and associated interaction(s) area(s) specification(s) created automatically from electronic document processing on another computer; such other computer paginating the documents for information viewing area(s) on such display device(s), record interaction(s) area(s) data corresponding with styled hypertext or interactive graphical elements within the electronic document, rasterising these document page(s) into screen page image pixmap(s), and compile interaction(s) area(s) data into persistent interaction(s) area(s) specification(s), together for communication to the display device. References to content elements in document pages can be associated with screen page images to allow end-users find information.

Abstract: This invention relates to a shotgun tube, either an inserted/attached short section that replaces a conventional choice device, or one that forms an integral section of the shotgun barrel. It is designed to provide major advances in two performance features of shotguns: (1) It provides an extremely uniform expanded shot pattern at short ranges 10 to 20 feet and (2) it provides rotational stabilization for both rifled slugs and sabot encased sub-caliber projectiles that significantly improves accuracy at longer ranges.