Abstract: A storage application is disclosed herein that employs a method for managing read and write requests associated with a database distributed across multiple replicas in multiple data centers. The storage application may be implemented on one or more computing devices in the context of a data center, cloud environment, or the like. The method includes the storage application receiving a client request to perform an operation with respect to an object at an any-local-quorum consistency level. In response to client request, the storage application iteratively generates and submits coordinator requests to the multiple data centers at a local-quorum consistency level, until one of the multiple data centers successfully replies to one of the coordinator requests with a result. The storage application then replies to the client request based on the result provided by the one of the multiple data centers.

Abstract: A storage application is disclosed herein that employs a method for managing read and write requests associated with a database distributed across multiple replicas in multiple data centers. The storage application may be implemented on one or more computing devices in the context of a data center, cloud environment, or the like. The method includes the storage application receiving a client request to perform an operation with respect to an object at an any-local-quorum consistency level. In response to client request, the storage application iteratively generates and submits coordinator requests to the multiple data centers at a local-quorum consistency level, until one of the multiple data centers successfully replies to one of the coordinator requests with a result. The storage application then replies to the client request based on the result provided by the one of the multiple data centers.

Abstract: A transducer or pickup system amplifying musical instruments (such as, e.g., an acoustic guitar), including at least one magnet, at least one inductance coil coupled to the magnet(s), and an arc shaped housing enclosing magnet(s) and inductance coil(s). Some embodiments of the invention may provide unique sound characteristics due to comb filtering effects associated with an arc shape arrangement of magnets and/or coils in the pickup. In some embodiments the arc shaped pickup and/or housing may be placed within 7.0-7.5 inches of an edge of a guitar's bridge, and/or may be clamped to the edge of a guitar's sound hole, and/or may be aligned with a circumference of the sound hole. Different configurations are described with regard to nonlimiting embodiments.

Abstract: A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.

Abstract: A sensor for measuring electrochemical impedance includes a primary circuit that includes a primary electrically conducting coil and a secondary circuit that includes a secondary electrically conducting coil. The primary electrically conducting coil is inductively coupled to the secondary circuit. During operation, the secondary electrically conductive couple has contact electrodes that contact a medium for which the impedance is to be measured. An alternating current source energizes the primary electrically conducting coil during impedance measurements.

Abstract: A sensor for measuring electrochemical impedance includes a primary circuit that includes a primary electrically conducting coil and a secondary circuit that includes a secondary electrically conducting coil. The primary electrically conducting coil is inductively coupled to the secondary circuit. During operation, the secondary electrically conductive couple has contact electrodes that contact a medium for which the impedance is to be measured. An alternating current source energizes the primary electrically conducting coil during impedance measurements.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: The invention provides a crystalline form of the compound of formula (Ia), methods for making the crystalline form of the compound of formula (Ia), and therapeutic methods for the use of the crystalline form of the compound of formula (Ia).

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: Single chain trimer (SCT) molecules are disclosed, comprising an MHC antigen peptide sequence, a ?2-microglobulin sequence and a full-length MHC class I heavy chain sequence, joined by linker sequences. Further described are nucleic acids encoding single chain trimers. Methods for expansion of antigen-specific T cell populations using single chain trimer molecules are also disclosed. In some configurations, these methods comprise co-culturing, in a first stage, CD8+ T cells from a donor with antigen presenting cells comprising an MHC antigen peptide, and co-culturing, in a second stage, the CD8+ T cells with cells comprising an SCT which has an MHC antigen peptide sequence identical to the sequence of the antigen peptide in the first stage. The methods can provide 10,000-100,000 fold expansion of antigen-specific CD8+ T cells within about 28 days after establishing culture, and can yield over 1 billion antigen-specific CD8+ T cells expanded from an individual donor.

Abstract: Single chain trimer (SCT) molecules are disclosed, comprising an MHC antigen peptide sequence, a ?2-microglobulin sequence and a full-length MHC class I heavy chain sequence, joined by linker sequences. Further described are nucleic acids encoding single chain trimers. Methods for expansion of antigen-specific T cell populations using single chain trimer molecules are also disclosed. In some configurations, these methods comprise co-culturing, in a first stage, CD8+ T cells from a donor with antigen presenting cells comprising an MHC antigen peptide, and co-culturing, in a second stage, the CD8+ T cells with cells comprising an SCT which has an MHC antigen peptide sequence identical to the sequence of the antigen peptide in the first stage. The methods can provide 10,000-100,000 fold expansion of antigen-specific CD8+ T cells within about 28 days after establishing culture, and can yield over 1 billion antigen-specific CD8+ T cells expanded from an individual donor.

Abstract: A filtered RJ11 connector module that is adaptable for mounting on Home Phone Networking Alliance (HPNA) network interface card useful for home networking applications and other communication protocols involves the integration of filter module into the connector module itself. The filter module comprises an isolation transformer, common mode choke, filter components, high voltage capacitor and surge protection device that may be configured to customize any network interface card. Mounting of at least two light indicators on a printed circuit board is another embodiment of the invention and therefore, also an integral part of a filtered RJ11 connector module. The housing consists of at least one plug-receiving opening for receiving connector plugs that are electrically connected to a transmission medium.

Abstract: The invention involves combining a plurality of vertical wells, each having a power conditioning unit located on the surface and an electrode in electrical contact with the reservoir, with a horizontal well extending through the reservoir in spaced relation to the vertical wells. The liner and tubing of the horizontal well function as the common return means for the circuit. Low frequency current is supplied to flow between the vertical and horizontal wells at adequate levels so as to cause heating in the near-wellbore regions of all the wells. Oil is produced, at the same time as electrical heating, at enhanced rates as a result.