Abstract: Connection systems for injection devices are disclosed. Also disclosed are injection devices and methods of using the same. A connection system includes a first and second connection assembly and a coupling assembly to secure the same. The first connection assembly connects to a medicament container, and the second connection assembly has a needle movable toward the medicament container. Removable flexible barriers are disposed on the first and second connection assemblies and can be removed once the connection assemblies are coupled together to form an aseptic connection between the two assemblies. The needle can be moved toward the medicament container to pierce a septum on the container to form a fluid communication between the container and the needle.

Abstract: Various container assemblies for containing a therapeutic liquid are provided. A first container assembly comprises a frame having a proximal end and a distal end and includes a plurality of axially extending legs, a collar attached to the plurality of axially extending legs at the proximal end of the frame, and a collapsible film covering the frame and attached to the distal end of the frame and at least a portion of the collar. A second container assembly for a therapeutic liquid comprises a collar and a collapsible film. The collar may comprise a plurality of hingedly connected segments configured to switch from an open configuration to a closed configuration. The collapsible film may be configured as a pouch having an open end attached to one end of the collar.