Patents by Inventor Laxman Nallan

Laxman Nallan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GEMCITABINE PRODRUGS
    Publication number: 20210346507
    Abstract: Provided herein are phosphorylated gemcitabine derivative prodrug compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of cancer.
    Type: Application
    Filed: August 14, 2019
    Publication date: November 11, 2021
    Inventors: Rajesh SHINDE, Laxman NALLAN
  • GEMCITABINE PRODRUGS
    Publication number: 20210323992
    Abstract: Provided herein are phosphorylated gemcitabine derivative prodrug compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of cancer.
    Type: Application
    Filed: August 14, 2019
    Publication date: October 21, 2021
    Inventors: Rajesh SHINDE, Laxman NALLAN
  • Pyrimidine derivatives as kinase inhibitors and their therapeutical applications
    Patent number: 10766879
    Abstract: The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 8, 2020
    Assignee: NANTBIOSCIENCE, INC.
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • Compositions and methods of targeting mutant K-ras
    Patent number: 10344026
    Abstract: Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: July 9, 2019
    Assignee: NantBio, Inc.
    Inventors: Chunlin Tao, Laxman Nallan, David G. Ho, Qinwei Wang, Paul Weingarten, Anna B. Juncker-Jensen
  • Substituted indol-5-ol derivatives and their therapeutic applications
    Patent number: 10245261
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 2, 2019
    Assignee: NantBio, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Substituted indol-5-ol derivatives and their therapeutical applications
    Patent number: 10160749
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: December 25, 2018
    Assignee: NantBio, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20180215734
    Abstract: The present invention provides kinase inhibitors with anti-proliferative activity comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof. In addition, the invention provides methods for making novel compounds and methods for using the compounds.
    Type: Application
    Filed: February 29, 2016
    Publication date: August 2, 2018
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS
    Publication number: 20180201610
    Abstract: Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 19, 2018
    Inventors: Chunlin Tao, Laxman Nallan, David G. Ho, Qinwei Wang, Paul Weingarten, Anna B. Juncker-Jensen
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20180155327
    Abstract: The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
    Type: Application
    Filed: February 27, 2015
    Publication date: June 7, 2018
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20170088544
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: October 4, 2016
    Publication date: March 30, 2017
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Substituted indol-5-ol derivatives and their therapeutical applications
    Patent number: 9458137
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 4, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Benzyl substituted triazine derivatives and their therapeutical applications
    Patent number: 9409903
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 9, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20150291564
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 15, 2015
    Applicant: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Triazine derivatives and their therapeutical applications
    Patent number: 9078902
    Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: July 14, 2015
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, David Ho, Neil Desai
  • BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20150057285
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 26, 2015
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Benzyl substituted triazine derivatives and their therapeutical applications
    Patent number: 8877924
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: November 4, 2014
    Assignee: NantBio Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Triazine Derivatives and their Therapeutical Applications
    Publication number: 20130023497
    Abstract: The present invention comprises inter alia triazine compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 7, 2010
    Publication date: January 24, 2013
    Inventors: Chunlin Tao, Qinwei Wang, Tulay Polat, Laxman Nallan, Neil Desai
  • BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20120264759
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Application
    Filed: June 8, 2010
    Publication date: October 18, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Triazine Derivatives and their Therapeutical Applications
    Publication number: 20120238576
    Abstract: The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 7, 2010
    Publication date: September 20, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, Lukasz Koroniak, Neil Desai
  • UREIDOPHENYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20120202818
    Abstract: The present invention provides Uredophenyl substituted triazine derivatives and provides methods of using these compounds to modulate protein kinases and methods of using these compounds to treat protein kinase mediated diseases and conditions.
    Type: Application
    Filed: June 9, 2010
    Publication date: August 9, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Lukasz Koroniak, Laxman Nallan, Neil Desai