Patents by Inventor Laxmi Adhikary

Laxmi Adhikary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid and efficient de-glycosylation of glycoproteins
    Patent number: 11530403
    Abstract: The present invention discloses rapid and cost-effective method of de-glycosyation of a glycoprotein, wherein, glycoprotein is combined with anionic surfactant and reducing agent and non-ionic surfactant in order to obtain stable denatured glycoprotein. An endoglycosidase is further added to denatured glycoprotein to cleave N-linked glycans in order to obtain de-glycosylated protein. A rapid tool for assessing the protein conformation by partial de-glycosylation is also presented wherein the partial de-glycosylated protein is analysed using capillary electrophoresis (CE-SDS).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 20, 2022
    Assignee: BIOCON LIMITED
    Inventors: Anushikha Thakur, Seija Rohil, Shrivardhan Patil, Meenakshi Sudhakaran, Laxmi Adhikary
  • Peptide mapping method for sequence identification of insulin and insulin analogues
    Patent number: 11442067
    Abstract: The invention relates to peptide mass fingerprinting technique for the proteins such as Human insulin and insulin analogs. The insulin analogues can vary at least by one amino acid, which is elusive to distinguish by currently available analytical methods. The invention further allows sequence confirmation of the peptide wherein the run time of the method is forty minutes. This method could be applied for molecules up to 50 kDa.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: September 13, 2022
    Inventors: Phanichand Kodali, Krishnappa Mane, Srivatsa Koduru, Ashutosh Sudhir Naik, Laxmi Adhikary
  • MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20210122829
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: April 29, 2020
    Publication date: April 29, 2021
    Inventors: RAMAKRISHNAN MELARKODE, PRADIP NAIR, SUNDARAJ DAVID RAJKUMAR, KEDARNATH NANJUND SASTRY, MONALISA CHATTERJI, LAXMI ADHIKARY, HEMA BALASUBRAMANIAN, JOSE ENRIQUE MONTERO CASIMIRO, JOSEFA LOMBARDERO VALLADARES, ROLANDO PEREZ RODRIGUEZ
  • PEPTIDE MAPPING METHOD FOR SEQUENCE IDENTIFICATION OF INSULIN AND INSULIN ANALOGUES
    Publication number: 20200378984
    Abstract: The invention relates to peptide mass fingerprinting technique for the proteins such as Human insulin and insulin analogs. The insulin analogues can vary at least by one amino acid, which is elusive to distinguish by currently available analytical methods. The invention further allows sequence confirmation of the peptide wherein the run time of the method is forty minutes. This method could be applied for molecules up to 50 kDa.
    Type: Application
    Filed: July 20, 2018
    Publication date: December 3, 2020
    Inventors: PHANICHAND KODALI, KRISHNAPPA MANE, SRIVATSA KODURU, ASHUTOSH SUDHIR NAIK, LAXMI ADHIKARY
  • RAPID AND EFFICIENT DE-GLYCOSYLATION OF GLYCOPROTEINS
    Publication number: 20200291377
    Abstract: The present invention discloses rapid and cost-effective method of de-glycosyation of a glycoprotein, wherein, glycoprotein is combined with anionic surfactant and reducing agent and non-ionic surfactant in order to obtain stable denatured glycoprotein. An endoglycosidase is further added to denatured glycoprotein to cleave N-linked glycans in order to obtain de-glycosylated protein. A rapid tool for assessing the protein conformation by partial de-glycosylation is also presented wherein the partial de-glycosylated protein is analysed using capillary electrophoresis (CE-SDS).
    Type: Application
    Filed: November 17, 2017
    Publication date: September 17, 2020
    Inventors: Anushikha THAKUR, Seija ROHIL, Shrivardhan PATIL, Meenakshi SUDHAKARAN, Laxmi ADHIKARY
  • Monoclonal antibody and a method thereof
    Patent number: 10669346
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: June 2, 2020
    Assignees: BIOCON LIMITED, CENTRO DE INMUNOLOGIA MOLECULAR
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
  • Methods for controlling fucosylation levels in proteins
    Patent number: 10308970
    Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: June 4, 2019
    Assignee: BIOCON LIMITED
    Inventors: Pradip Nair, Ramakrishnan Melarkode, Rasika Venkataraman, Laxmi Adhikary, Ankur Bhatnagar, Sunaina Prabhu, Kriti Shukla, Dinesh Baskar, Saravanan Desan, Harish Venkatraman Pai, Jose Enrique Montero Casimiro
  • A MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20180258179
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: May 9, 2018
    Publication date: September 13, 2018
    Inventors: RAMAKRISHNAN MELARKODE, PRADIP NAIR, SUNDARAJ DAVID RAJKUMAR, KEDARNATH NANJUND SASTRY, MONALISA CHATTERJI, LAXMI ADHIKARY, HEMA BALASUBRAMANIAN, JOSE ENRIQUE MONTERO CASIMIRO, JOSEFA LOMBARDERO VALLADARES, ROLANDO PEREZ RODRIGUEZ
  • Monoclonal antibody and a method thereof
    Patent number: 10000573
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: June 19, 2018
    Assignees: CENTRO DE IMMUNOLOGIA MOLECULAR, BIOCON LIMITED
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
  • METHODS FOR CONTROLLING FUCOSYLATION LEVELS IN PROTEINS
    Publication number: 20180087080
    Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.
    Type: Application
    Filed: November 21, 2017
    Publication date: March 29, 2018
    Inventors: PRADIP NAIR, RAMAKRISHNAN MELARKODE, RASIKA VENKATARAMAN, LAXMI ADHIKARY, ANKUR BHATNAGAR, SUNAINA PRABHU, KRITI SHUKLA, DINESH BASKAR, SARAVANAN DESAN, HARISH VENKATRAMAN PAI, JOSE ENRIQUE MONTERO CASIMIRO
  • Methods for controlling fucosylation levels in proteins
    Patent number: 9856502
    Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: January 2, 2018
    Assignee: BIOCON LIMITED
    Inventors: Pradip Nair, Ramakrishnan Melarkode, Rasika Venkataraman, Laxmi Adhikary, Ankur Bhatnagar, Sunaina Prabhu, Kriti Shukla, Dinesh Baskar, Saravanan Desan, Harish Venkatraman Pai, Jose Enrique Montero Casimiro
  • MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20170281808
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: May 31, 2017
    Publication date: October 5, 2017
    Inventors: RAMAKRISHNAN MELARKODE, PRADIP NAIR, SUNDARAJ DAVID RAJKUMAR, KEDARNATH NANJUND SASTRY, MONALISA CHATTERJI, LAXMI ADHIKARY, HEMA BALASUBRAMANIAN, MONTERO CASIMIRO, JOSEFA LOMBARDERO VALLADARES, ROLANDO PEREZ RODRIGUEZ
  • Monoclonal antibody and a method thereof
    Patent number: 9670285
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: June 6, 2017
    Assignees: BIOCON LIMITED, CENTRO DE INMUNOLOGIA MOLECULAR
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
  • MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20160168256
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 16, 2016
    Inventors: RAMAKRISHNAN MELARKODE, PRADIP NAIR, SUNDARAJ DAVID RAJKUMAR, KEDARNATH NANJUND SASTRY, MONALISA CHATTERJI, LAXMI ADHIKARY, HEMA BALASUBRAMANIAN, JOSE ENRIQUE MONTERO CASIMIRO, JOSEFA LOMBARDERO VALLADARES, ROLANDO PEREZ RODRIGUEZ
  • METHODS FOR CONTROLLING FUCOSYLATION LEVELS IN PROTEINS
    Publication number: 20160138065
    Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.
    Type: Application
    Filed: July 23, 2014
    Publication date: May 19, 2016
    Inventors: PRADIP NAIR, RAMAKRISHNAN MELARKODE, RASIKA VENKATARAMAN, LAXMI ADHIKARY, ANKUR BHATNAGAR, SUNAINA PRABHU, KRITI SHUKLA, DINESH BASKAR, SARAVANAN DESAN, HARISH VENKATRAMAN PAI, JOSE ENRIQUE MONTERO CASIMIRO
  • Monoclonal antibody and a method thereof
    Patent number: 9217037
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: December 22, 2015
    Assignees: BIOCON LIMITED, CENTRO DE INMUNOLGIA MOLECULAR
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
  • MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20140031529
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 30, 2014
    Applicants: CENTRO DE INMUNOLOGIA MOLECULAR, BIOCON LIMITED
    Inventors: RAMAKRISHNAN MELARKODE, PRADIP NAIR, SUNDARAJ DAVID RAJKUMAR, KEDARNATH NANJUND SASTRY, MONALISA CHATTERJI, LAXMI ADHIKARY, HEMA BALASUBRAMANIAN, JOSE ENRIQUE MONTERO CASIMIRO, JOSEFA LOMBARDERO VALLADARES, ROLANDO PEREZ RODRIGUEZ
  • Monoclonal antibody and a method thereof
    Patent number: 8524233
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: September 3, 2013
    Assignee: Biocon Limited & Centro de Immunologia Molecular
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez
  • Process for the production of macrolides using a novel strain, sp. BICC 7522
    Patent number: 8012723
    Abstract: The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: September 6, 2011
    Assignee: Biocon, Ltd.
    Inventors: Madhav Kulkarni, Surekha K. Prabhu, Madenahally Channabasappa Shivakumar, Prijyajit Sengupta, Sanjay Tiwari, Rakesh Mendhe, Nitin Patil, Laxmi Adhikary, Anand Khedkar, Ramakrishnan Melarkode, Ramavana Gururaja, Shrikumar Suryanarayan
  • MONOCLONAL ANTIBODY AND A METHOD THEREOF
    Publication number: 20110002939
    Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1(D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 6, 2011
    Inventors: Ramakrishnan Melarkode, Pradip Nair, Sundaraj David Rajkumar, Kedarnath Nanjund Sastry, Monalisa Chatterji, Laxmi Adhikary, Hema Balasubramanian, Jose Enrique Montero Casimiro, Josefa Lombardero Valladares, Rolando Perez Rodriguez