Patents by Inventor Laxmi Manral

Laxmi Manral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of fentanyl
    Patent number: 8399677
    Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: March 19, 2013
    Assignee: Defence Research & Development Organisation
    Inventors: Pradeep Kumar Gupta, Laxmi Manral, Kumaran Ganesan, Ramesh Chandra Malhotra, Krishnamurthy Sekhar
  • Method for the Preparation of Fentanyl
    Publication number: 20110021781
    Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride (NPP) with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-ANPP), (b) reacting the 4-ANPP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.
    Type: Application
    Filed: March 9, 2009
    Publication date: January 27, 2011
    Applicant: Director General Defence Research & Development Organization, Ministry of Defence
    Inventors: Pradeep Kumar Gupta, Laxmi Manral, Kumaran Ganesan, Ramesh Chandra Malhotra, Krishnamurthy Sekhar