Patents by Inventor Laxminarayana Devireddy

Laxminarayana Devireddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method Of Inducing Apoptosis In Lymphoid Cells
    Publication number: 20080249010
    Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.
    Type: Application
    Filed: June 12, 2007
    Publication date: October 9, 2008
    Inventors: Michael R. Green, Laxminarayana Devireddy, Jose G. Teodoro, Fabian Richard
  • Method of inducing apoptosis in lymphoid cells
    Patent number: 7235520
    Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: June 26, 2007
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Laxminarayana Devireddy, Jose G. Teodoro, Fabian Richard
  • 24p3 receptors and uses thereof
    Publication number: 20050214219
    Abstract: A receptor for 24p3 has been identified. The receptor has been found to play a role in both iron transport and apoptosis. Accordingly, compounds that modulate the expression or activity of a 24p3R are useful for modulating iron transport and apoptosis.
    Type: Application
    Filed: November 22, 2004
    Publication date: September 29, 2005
    Inventors: Michael Green, Laxminarayana Devireddy, Claude Gazin
  • Method of inducing apoptosis in lymphoid cells
    Publication number: 20020128194
    Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.
    Type: Application
    Filed: September 21, 2001
    Publication date: September 12, 2002
    Inventors: Michael R. Green, Laxminarayana Devireddy, Jose G. Teodoro, Fabian Richard