Patents by Inventor Lazzaro Feliciani

Lazzaro Feliciani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF A KEY INTERMEDIATE OF SIPONIMOD
    Publication number: 20230322658
    Abstract: The present invention relates to a process for the preparation of a key intermediate and other intermediates useful for the synthesis of Siponimod, a drug used for the treatment of multiple sclerosis. Object of the invention are also said novel intermediates.
    Type: Application
    Filed: July 30, 2021
    Publication date: October 12, 2023
    Applicant: OLON S.P.A.
    Inventors: Matteo VALLI, Mara SADA, Lazzaro FELICIANI, Giorgio BERTOLINI
  • PROCESS FOR THE PREPARATION OF LASMIDITAN AND OF A SYNTHESIS INTERMEDIATE
    Publication number: 20230098051
    Abstract: A process for the preparation of Lasmiditan and of a synthesis intermediate of formula (II): including reacting a compound of Formula (III) wherein X and Y, each independently, represent a halogen atom, with an aqueous solution of ammonia, in presence of at least one bidentate ligand and of at least one copper-based catalyst, and optionally converting the so-obtained compound of Formula (II) into a salt and/or solvate thereof.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 30, 2023
    Inventors: Giuseppe CREMONESI, Christian INVERNIZZI, Mara SADA, Lazzaro FELICIANI, Giorgio BERTOLINI
  • Process for the preparation of lifitegrast
    Patent number: 11498917
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: November 15, 2022
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • Process for the preparation of Crisaborole in a stable crystal form
    Patent number: 11325922
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 10, 2022
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • PROCESS FOR THE PREPARATION OF LIFITEGRAST
    Publication number: 20210246123
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Application
    Filed: June 13, 2019
    Publication date: August 12, 2021
    Applicant: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • A PROCESS FOR THE PREPARATION OF CRISABOROLE
    Publication number: 20210070781
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: June 25, 2018
    Publication date: March 11, 2021
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR THE PREPARATION OF CRISABOROLE IN A STABLE CRYSTAL FORM
    Publication number: 20200407377
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: July 10, 2020
    Publication date: December 31, 2020
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR THE PREPARATION OF CRISABOROLE
    Publication number: 20190194230
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: March 21, 2018
    Publication date: June 27, 2019
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • Process for the preparation of crisaborole
    Patent number: 10329311
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 25, 2019
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • PROCESS FOR THE PREPARATION OF THE AMORPHOUS FORM OF IBRUTINIB AND NOVEL CRYSTALLINE FORM
    Publication number: 20180282339
    Abstract: Subject-matter of the invention is a process for the preparation of the amorphous form of ibrutinib and a novel crystalline form.
    Type: Application
    Filed: November 16, 2016
    Publication date: October 4, 2018
    Inventors: Giorgio BERTOLINI, Lazzaro FELICIANI, Ilaria FERRANDO, Mara SADA
  • Process for the preparation of indanamine derivatives and new synthesis intermediates
    Patent number: 10059653
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 28, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Paolangelo Cerea, Corrado Colli, Lazzaro Feliciani, Federico Gassa, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • PROCESS FOR THE PREPARATION OF INDANAMINE DERIVATIVES AND NEW SYNTHESIS INTERMEDIATES
    Publication number: 20170362161
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: January 19, 2016
    Publication date: December 21, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Paolangelo CEREA, Corrado COLLI, Lazzaro FELICIANI, Federico GASSA, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC
  • CRYSTALLINE COMPOUNDS OF DABIGATRAN ETEXILATE
    Publication number: 20170165247
    Abstract: The present invention relates to new crystalline compounds of dabigatran etexilate, namely to crystalline compounds comprising mixtures of dabigatran etexilate and an acid. The invention also relates to processes for the preparation of the new crystalline compounds, pharmaceutical compositions comprising them and their use in therapy.
    Type: Application
    Filed: July 17, 2015
    Publication date: June 15, 2017
    Inventors: Giorgio BERTOLINI, Lazzaro FELICIANI, Ilaria FERRANDO
  • AMORPHOUS FORM AND NEW CRYSTALLINE FORMS OF MACITENTAN
    Publication number: 20170158645
    Abstract: The present invention relates to the amorphous form of macitentan and to new crystalline forms thereof. The invention also relates to processes for the preparation of the new compounds, to the pharmaceutical compositions comprising them and to the use thereof in the therapy.
    Type: Application
    Filed: July 13, 2015
    Publication date: June 8, 2017
    Inventors: Giorgio BERTOLINI, Lazzaro FELICIANI, Ilaria FERRANDO
  • Process for the preparation of bosentan
    Patent number: 9233936
    Abstract: The invention concerns a new process for the preparation of bosentan or bosentan monohydrate by reaction of compound of Formula II with ethylene glycol in the presence of potassium bases and the potassium salt of bosentan.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: January 12, 2016
    Assignee: SIFAVITOR S.R.L.
    Inventors: Giancarlo Biffi, Lazzaro Feliciani, Enrico Viscardi
  • PROCESS FOR THE PREPARATION OF BOSENTAN
    Publication number: 20120041200
    Abstract: The invention concerns a new process for the preparation of bosentan or bosentan monohydrate by reaction of compound of Formula II with ethylene glycol in the presence of potassium bases and the potassium salt of bosentan.
    Type: Application
    Filed: March 3, 2010
    Publication date: February 16, 2012
    Inventors: Giancarlo Biffi, Lazzaro Feliciani, Enrico Viscardi
  • PROCESS FOR THE PREPARATION OF PROSTAGLANDIN DERIVATIVES
    Publication number: 20120016136
    Abstract: The invention concerns a new process for the preparation of prostaglandin derivatives, in particular prostaglandin F2? derivatives, for example bimatoprost, latanoprost and travoprost, the new intermediates of said process and their use in the preparation of prostagblandin derivatives.
    Type: Application
    Filed: February 18, 2010
    Publication date: January 19, 2012
    Inventors: Giancarlo Biffi, Alessandro D'Alfonso, Lazzaro Feliciani, Alessio Porta, Giovanni Vidari, Enrico Viscardi, Giuseppe Zanoni
  • ESTERIFICATION PROCESS OF PROSTAGLANDINS AND ANALOGUES THEREOF
    Publication number: 20110124064
    Abstract: The invention relates to a process for enzymatically catalyzed esterification of prostaglandins or analogues thereof.
    Type: Application
    Filed: May 8, 2009
    Publication date: May 26, 2011
    Inventors: Giancarlo Biffi, Lazzaro Feliciani, Alessandro D'Alfonso, Alessio Porta, Giuseppe Zanoni