Abstract: Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K) L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.

Abstract: An optical lens assembly for a near-eye display device includes a light box and a diffractive optical element (DOE). The light box has a first layer facing a display screen of the near-eye display device and a second layer facing the DOE. The light box is configured to receive a first light from a display screen of the near-eye display device and transmit at least a portion of the first light to the DOE through a folded optical path, where the first layer and the second layer are flat. The DOE aligned with an optical axis of an eye and is configured to receive a second light from the light box and converge the second light to the eye.

Abstract: Methods, systems, and devices for wireless communications are described. that support preconfigured uplink resources (PUR) in wireless communications. A base station may communicate that support for PUR is available, and may allocate PUR resources to a user equipment (UE) based on requests from the UE. The UE may receive an indication that the base station supports PUR, such as via a system information block (SIB), determine to request PUR, and transmit a PUR request message to the base station. A PUR response from the base station may indicate configuration, or reconfiguration of PUR allocation for the UE that may be used for uplink transmissions, or release of the PUR allocation.

Abstract: Disclosed herein is a trusted platform module (TPM) for authenticating a secure system, the TPM including: one or more registers to automatically generate and maintain hash values indicating current state values of the TPM, secure memory to store a key in association with a secure system, and a processor in network communication with the registers and the secure memory. During a secure boot up process, the processor can perform operations including: deriving the key for the secure system from the hash values that are automatically generated by the one or more registers, calculating a Hash-based Message Authentication Code (HMAC) value using the key, generating, based on the HMAC value, an authentication login token for the secure system, and advancing the hash values that are maintained by the one or more registers from their initial state during the secure boot up process.

Abstract: A system and method for translating a 3D visualization to a 2D visualization is provided. Data for a 3D visualization is received and includes layers of voxels that are processed to determine a type of terrain and color associated with the terrain type. Each voxel in a base layer of the 3D visualization is transformed into a tile of pixels for a 2D visualization. The color associated with the layers is assigned to the tiles by identifying, for each such layer, a marker for each voxel in that layer that indicates a presence or absence of the terrain type for that layer and applying the color associated with the layer to at least a portion of the tiles based on the markers. When multiple colors are applied to one of the tiles, the color associated with the layer furthest from the base layer is selected. The 2D visualization is output.

Abstract: The disclosed technology provides for managing, authenticating, and authorizing data sharing between parties utilizing multi-party-computation (“MPC”). A method can include: receiving, by a server from a party B system, (i) a request to access first data of a party A system and (ii) second data of party B, sending, to the party systems, an authorization request to authorize the request, receiving, from the party systems, MPC shares associated with trusted third party processing of data, the MPC shares generated as part of a digital contract between the parties for combining the first and second data within an environment of the trusted third party, to which neither party has access, retrieving MPC authorization functions associated with the digital contract, determining whether the requested access is authorized based on the MPC shares and MPC authorization functions, and performing data processing operations using the first and second data in a secure environment.

Abstract: A nest for the storage of medical device components, including a top surface, a bottom surface, and a plurality of receptacles for the storage of a plurality of medical device components therein. Each of the plurality of receptacles may include a sidewall portion extending downward from the bottom surface of the nest. Additionally, a plurality of ring-shaped protrusions may be provided to extend upward from the top surface of the nest and surround at least some of the plurality of receptacles. The plurality of ring-shaped protrusions may be sized and configured to receive a bottom portion of a corresponding one of the plurality of receptacles when a plurality of nests are vertically stacked relative to one another.

Abstract: Embodiments of the present disclosure disclose a switching method and apparatus, a network function, and a storage medium. The method comprises: a first network function selects or discovers, on the basis of location information of one or more user equipment (UE), a second network function corresponding to each UE; and the first network function decides to respectively transfer or transmit a data subscription or data request about the one or more UE to the second network function corresponding to each UE.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating includes a polymer, collagen, glycerin and a hemostatic agent. The polymer is selected from the group of polyhydroxybutyrate, polyglycerol sebacate and adducts of polyglycerol sebacate. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.

Abstract: A method and device for protecting a local area network including nodes allowing an extension of wireless communication coverage in order to increase the range of the local area network by coordinating a plurality of access points integrated in the nodes, the nodes being interconnected by a backhaul subnetwork, each node in the backhaul subnetwork transmitting at least one wireless network referred to as a fronthaul network, the method includes the steps of: detecting a connection of a station by a cable connection to a network switch included in the local area network, the network switch being connected to the backhaul subnetwork by a cable connection, establishing secure connections between each node if the connection of the station by a cable connection to the network switch is detected, managing the nodes of the network connected to the network switch with filtering rules applied to the data received by the nodes.

Abstract: Embodiments disclosed herein relate to methods of constructing a structure and related non-transitory computer readable medium. In an embodiment, the method includes (a) defining a vertical first slice and a second vertical slice of the structure. A lateral cross-section of the structure within the first vertical slice is different than the lateral cross-section of the structure for the second vertical slice. In addition, the method includes (b) depositing a plurality of first vertically stacked layers of an extrudable building material with a printing assembly to form the first vertical slice. Further, the method includes depositing a plurality of second vertically stacked layers of the extrudable building material atop the first vertical slice with the printing assembly to form the second vertical slice.

Abstract: Disclosed is an online optimization method for a power consumption policy of a terminal of Internet of things (IoT), including: performing comprehensive scanning on a user terminal and a link, and obtaining a link behavior graph; inputting the link behavior graph into a simulation based optimization (SBO) system to obtain power consumption parameters for minimizing power consumption of the user terminal; performing centralized storage on the link behavior graph and the power consumption parameters; regularly sending, by the user terminal, operation data to a server, and evaluating, by the server, whether a power consumption policy needs to be optimized; and issuing, by the server, a parameter update instruction to complete the upgrading of the power consumption policy of the user terminal. In the present disclosure, the update of the power consumption policy of the user terminal can be conveyed more quickly and more efficiently.

Abstract: Example embodiments provide a system for training a data coding pipeline including a feature extractor neural network, an encoder neural network, and a decoder neural network configured to reconstruct input data based on encoded features. A plurality of losses corresponding to different tasks may be determined for the coding pipeline. Tasks may be performed based on an output of the coding pipeline. A weight update may be determined for at least a subset of the coding pipeline based on the plurality of losses. The weight update may be configured to reduce a number of iterations for fine-tuning the coding pipeline for one of the tasks. This enables faster adaptation of the coding pipeline for one of the tasks after deployment of the coding pipeline. Apparatuses, methods, and computer programs are disclosed. Apparatuses, methods, and computer programs are disclosed.

Abstract: Improved software technology and techniques for enabling creation and management of a customized work breakdown structure (“WBS”) for a specific project may comprise various phases. For instance, a first phase may involve defining an organization-level WBS comprising a first set of customized, multi-dimensional WBS codes that serve as a starting point for the WBS codes to use for projects being handled by the organization, a second phase may involve defining a project-level WBS comprising a second set of customized, multi-dimensional WBS codes to use for a particular project being handled by the organization, and a third phase may involve using the defined project-level WBS to manage certain aspects of the particular project. Further, access to customize WBS variables may be regulated based on user access permissions information indicated by an organization and/or project-level WBS.

Abstract: The vehicle-mounted antenna includes a power supply pin disposed upright on the body, a first radiation element extending from the power supply pin in a horizontal plane rearward of the vehicle, and a second radiation element extending from the power supply pin in a horizontal plane forward of the vehicle. The first tip portion of the first radiation element is fixed to the body via a first insulating member. The second radiation element is longer than the first radiation element and comprises a second tip portion and an intermediate portion. The second tip portion is connected to the body. The intermediate portion is located between the power supply pin and the second tip portion and is fixed to the body via the second insulating member.

Abstract: The present invention relates to a recombinant microorganism which is modified to be capable of producing diosmin and hesperidin and to the use thereof for producing diosmin and/or hesperidin.

Abstract: The present invention discloses a strain of ammonium sulfate-tolerant Saccharomyces cerevisiae, and a screening method thereof. The strain of ammonium sulfate-tolerant Saccharomyces cerevisiae, named Saccharomyces cerevisiae Z-1, was preserved in Guangdong Microbial Culture Collection Center on Mar. 3, 2023, with a preservation number of GDMCC NO: 63227 and a preservation address of Floor 5, Building 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou. The ammonium sulfate-tolerant Saccharomyces cerevisiae Z-1 provided by the present invention may grow and breed in an environment containing 1.0 mol/L NH4+ (6.6% ammonium sulfate), and the protein content of the strain can reach 51.97%; and as a fermentation strain for protein feed, the strain of the present invention not only can adapt to the high-tolerance environment, but also can increase the protein content of the protein feed, and is an excellent strain for solid-state fermentation.

Abstract: The present disclosure generally relates to spin-orbit torque (SOT) device comprising a bismuth antimony (BiSb) layer. The SOT device comprises a seed layer and a BiSb layer having a (012) orientation. The seed layer comprises at least one of an amorphous/nanocrystalline material with a nearest neighbor x-ray diffraction peak with a d-spacing in the range of about 2.02 ? to about 2.20 ?; a polycrystalline material having a (111) orientation and an a-axis of about 3.53 ? to about 3.81 ?; and a polycrystalline material having a cubic (100) or tetragonal (001) orientation and an a-axis of about 4.1 ? to about 4.7 ?. When the seed layer comprises an amorphous material or a polycrystalline material having a (111), the BiSb layer is doped, and the seed layer has a lower a/c ratio than when the seed layer comprises polycrystalline material having a cubic (100) or tetragonal (001) orientation.

Abstract: In general, this disclosure is directed to presenting eligible promotional items on an offer description page. In some embodiments, the eligible promotional items are personalized based on customer relevancy. One aspect is a method for dynamically presenting items eligible for a promotion on an e-commerce application of a retailer, the method comprising receiving, from a customer user computing device associated with a customer user, a request for an offer description page of the promotion, retrieving the items eligible for the promotion and user interaction data associated with the customer user, ranking the items eligible for the promotion based as least in part on the user interaction data, and generating a user interface for the offer description page presenting the items eligible for the promotion according to the ranking, wherein the offer description page initially displays a subset of the highest ranked items eligible for the promotion.