Patents by Inventor Le-Cun Xu

Le-Cun Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bifunctional chelators and conjugates
    Patent number: 11964948
    Abstract: Provided are new bifunctional chelators for use in the manufacture of radiolabeled targeting agents for therapeutic or diagnostic use. Also provided are conjugates of the new bifunctional chelators with various cancer antigen targeting agents.
    Type: Grant
    Filed: October 8, 2023
    Date of Patent: April 23, 2024
    Assignee: Actinium Pharmaceuticals, Inc.
    Inventors: Le-Cun Xu, Denis Beckford Vera
  • BIFUNCTIONAL CHELATORS AND CONJUGATES
    Publication number: 20240082438
    Abstract: Provided are new bifunctional chelators for use in the manufacture of radiolabeled targeting agents for therapeutic or diagnostic use. Also provided are conjugates of the new bifunctional chelators with various cancer antigen targeting agents.
    Type: Application
    Filed: October 5, 2023
    Publication date: March 14, 2024
    Applicant: ACTINIUM PHARMACEUTICALS, INC.
    Inventors: Le-Cun XU, Denis BECKFORD-VERA
  • BIFUNCTIONAL CHELATORS AND CONJUGATES
    Publication number: 20240051928
    Abstract: Provided are new bifunctional chelators for use in the manufacture of radiolabeled targeting agents for therapeutic or diagnostic use. Also provided are conjugates of the new bifunctional chelators with various cancer antigen targeting agents.
    Type: Application
    Filed: October 8, 2023
    Publication date: February 15, 2024
    Applicant: ACTINIUM PHARMACEUTICALS, INC.
    Inventors: Le-Cun XU, Denis BECKFORD-VERA
  • CANCER IMAGING AGENT
    Publication number: 20170368208
    Abstract: The present disclosure relates to imaging agent formulations, methods for preparing imaging agent formulations and methods for using the same. The present disclosure also relates to kits for imaging agent formulations.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 28, 2017
    Inventor: Le-Cun XU
  • Processes for preparing tubulysins
    Patent number: 9499849
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 22, 2016
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Christopher Paul Leamon
  • PROCESSES FOR PREPARING TUBULYSINS
    Publication number: 20160177363
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Iontcho Radoslavov VLAHOV, Michael GROANING, Paul Joseph KLEINDL, Hari Krishna R. SANTHAPURAM, Fei YOU, Kevin Yu WANG, Le-Cun XU, Katheryn Marie STANFORD, Allen RITTER, Christopher Paul LEAMON
  • Processes for preparing tubulysins
    Patent number: 9273091
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: March 1, 2016
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Christopher Paul Leamon
  • PROCESSES FOR PREPARING TUBULYSINS
    Publication number: 20150225447
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Application
    Filed: October 20, 2014
    Publication date: August 13, 2015
    Applicant: ENDOCYTE, INC.
    Inventors: Iontcho Radoslavov VLAHOV, Michael GROANING, Paul Joseph KLEINDL, Hari Krishna R. SANTHAPURAM, Fei YOU, Kevin Yu WANG, Le-Cun XU, Katheryn Marie STANFORD, Allen RITTER, Christopher Paul LEAMON
  • Processes for preparing tubulysins
    Patent number: 8889880
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: November 18, 2014
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Christopher Paul Leamon
  • PROCESSES FOR PREPARING TUBULYSINS
    Publication number: 20130137139
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Application
    Filed: August 5, 2011
    Publication date: May 30, 2013
    Applicant: ENDOCYTE, INC.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Paul Christopher Leamon
  • Synthesis and purification of pteroic acid and conjugates thereof
    Patent number: 8044200
    Abstract: Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: October 25, 2011
    Assignee: Endocyte, Inc.
    Inventors: Le-Cun Xu, Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Hari Krishna Santhapuram, Chunhong Li
  • Synthesis and Purification of Pteroic Acid and Conjugates Thereof
    Publication number: 20080207625
    Abstract: Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described.
    Type: Application
    Filed: March 14, 2006
    Publication date: August 28, 2008
    Applicant: Endocyte, Inc.
    Inventors: Le-Cun Xu, Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Hari Krishna Santhapuram, Chunhong Li