Abstract: A P2X7 purinergic receptor has been isolated from the genome of Macaca mulatta (Rhesus monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes that are agonists or antagonists of the receptor.

Abstract: The present invention relates to a method for eliciting a disease modifying effect on an arthritic condition in a mammal which comprises administering to the mammal a therapeutically effective amount of an anti-resorptive compound. The present invention also relates to method for eliciting a disease modifying effect on subchondral bone sclerosis, preventing osteophyte formation or progression and preventing joint destruction in a mammal which comprises administering to the mammal a therapeutically effective amount of an anti-resorptive compound.

Abstract: The Macaca mulatta (rhesus monkey) NURR1 nuclear receptor and the nucleic acid encoding the rhesus monkey NURR1 are described. Further described are methods for identifying analytes which modulate expression or activity of the rhNURR1 for treating or inhibiting inflammatory diseases such as osteoarthritis, bone disorders, neurological such as Parkinson's disease, psychotic diseases such as bipolar diseases, and prostate disorders.

Abstract: The present invention provides for methods for treating or preventing an inflammatory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a cyclooxygenase-2 specific inhibitor in combination with an ?V?3, ?V?5? and/or ?V?6 integrin receptor antagonist in an amount effective to treat or prevent the inflammatory disease or condition. The present invention also provides for pharmaceutical compositions for the treatment or prevention of an inflammatory disease or condition. Further, the invention provides for the manufacture of a medicament useful in the treatment or prevention of an inflammatory disease or condition.