Abstract: The compound as shown in formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof, and a preparation method therefor, and the use thereof as an MAT2A inhibitor. Ring A, ring Q, X, Y, X1, X2, L and R1 in formula (I) are as defined in the description.

Abstract: The present disclosure provides a semiconductor device and a manufacturing method therefor. The method includes: providing a semiconductor structure, the semiconductor structure including a semiconductor substrate, a gate disposed on the semiconductor substrate, and an interlayer dielectric layer covering the semiconductor substrate and the gate; wherein the semiconductor structure further includes a first source/drain region and a second source/drain region; defining first connecting holes and at least one first air hole on the first source/drain region and/or the second source/drain region; wherein at least one first air hole is arranged between each adjacent two first connecting holes in an X direction and/or a Y direction, the X direction being a gate length direction, the X direction being perpendicular to the Y direction; sealing each first air hole to define a first cavity in the first air hole; and filling each first connecting hole with a conductive material.

Abstract: A quantum dot Light Emitting Diode, including an anode, a cathode, and a quantum dot light-emitting layer between the anode and the cathode, a carrier functional layer is arranged between the anode and the cathode. The carrier functional layer contains a magnetic material.

Abstract: A flexible display screen includes: a flexible substrate (1); an OLED device layer (2) formed on the flexible substrate (1); an encapsulation layer(3), disposed on the OLED device layer(2) and encapsulating the OLED device layer (2); and an encapsulation protection layer (4) formed on the encapsulation layer (3). The embodiments of the present disclosure also provide a flexible display device and a manufacturing method of the flexible display screen.

Abstract: An electronic device may include an antenna and a coaxial cable coupled to the antenna. The coaxial cable may have a signal conductor coupled to an antenna resonating element of the antenna and a ground conductor coupled to an antenna ground of the antenna. The ground conductor may include an ungrounded segment that is separated from the antenna ground by a gap. A capacitive coupling between the ground conductor in the ungrounded segment and the antenna ground via the gap may form an impedance matching component for the coaxial cable. A dielectric retention layer may overlap the coaxial cable and hold the coaxial cable in place relative to the antenna ground to maintain the gap.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: An alginate hydrogel-based thin-film heat flux sensor for billet crystallizer includes an alginate hydrogel substrate. The alginate hydrogel substrate is configured in a U-shaped planar structure. The U-shaped planar structure includes a first side and a second side, and the first side is longer than the second side. An inner surface of the alginate hydrogel substrate is provided with a first film thermocouple and a second film thermocouple. The first film thermocouple is in crosslinking connection with the second film thermocouple.

Abstract: The present disclosure discloses a rolling ring shrink fitting tool for rotary equipment, including a lifting frame; a movement slot is formed in a bottom surface of a top of the lifting frame; an output end of a first motor is connected with a main gear; guide rollers are embedded in a lifting seat through bearings; shrink fitting plates are two semicircular structures; lifting lugs are welded on outer sides of the shrink fitting plates; tooth rings are arranged outside the shrink fitting plates; stop rods are fixed on inner walls of the tooth rings; supporting screw rods are embedded at sunken positions on inner walls of the shrink fitting plates through bearings.

Abstract: The application proposes a non-destructive testing method for the sealing degree of the small cigarette box packaging, which includes placing the small cigarette box to be tested in an airtight chamber, using a balance cabin to quickly form a stable negative pressure in the airtight chamber; The pressure change of the sealed chamber is continuously measured until equilibrium, and the data model is analyzed and established by using Darcy's law, Fick's diffusion law and the physical process of molecular kinetic theory. Through the non-destructive testing method for the sealing degree of the small cigarette box packaging of the present invention, the traditional destructive measurement (damaged small box packaging) for measuring the sealing degree of cigarette small box is changed into non-destructive testing; The test results have specific physical meaning; The test time of a single sample is reduced to ? of the time of destructive test.

Abstract: The present disclosure discloses a rolling ring shrink fitting tool for rotary equipment, including a lifting frame; a movement slot is formed in a bottom surface of a top of the lifting frame; an output end of a first motor is connected with a main gear; guide rollers are embedded in a lifting seat through bearings; shrink fitting plates are two semicircular structures; lifting lugs are welded on outer sides of the shrink fitting plates; tooth rings are arranged outside the shrink fitting plates; stop rods are fixed on inner walls of the tooth rings; supporting screw rods are embedded at sunken positions on inner walls of the shrink fitting plates through bearings.

Abstract: A method comprises obtaining a test specification document of a user, wherein the test specification document comprises a test scheme based on a natural language; recommending, to the user and based on a first test step in the test scheme, a test interface set comprising a plurality of test interfaces for implementing a second test step, performing, by the user, a selection operation on the test interfaces in the test interface set; and generating, based on the selection operation, one or more test cases.

Abstract: A target device receives a plurality of pieces of first data, where each piece of the plurality of pieces of first data includes first ephemeris information and/or first almanac information. The target device identifies abnormal first data among the plurality of pieces of first data, where the plurality of pieces of first data include the abnormal first data, and the plurality of pieces of first data are obtained by the target device from a plurality of access network devices. A plurality of pieces of first ephemeris information and/or a plurality of pieces of first almanac information in the plurality of pieces of first data correspond to a first satellite. The target device may determine, by using the plurality of pieces of first ephemeris information and/or the plurality of pieces of first almanac information, that a piece of first ephemeris information and/or a piece of first almanac information is abnormal.

Abstract: This document describes techniques and systems of a radar system with modified orthogonal linear antenna subarrays and an angle-finding module. The described radar system includes a first one-dimensional (1D) (e.g., linear) subarray; a second 1D subarray positioned orthogonal to the first 1D subarray; and a two-dimensional (2D) subarray. Using electromagnetic energy received by the first 1D subarray and the second 2D subarray, azimuth angles and elevation angles associated with one or more objects can be determined. The radar system associates, using electromagnetic energy received by the 2D subarray, pairs of an azimuth angle and an elevation angle to the respective objects. In this way, the described systems and techniques can reduce the number of antenna elements while maintaining the angular resolution of a rectangular 2D array with similar aperture sizing.

Abstract: The invention provides an anti-C5 humanized monoclonal antibody with low immunogenicity and low ADCC/CDC function and its application. By modifying the amino acid sequence of the framework region of Eculizumab monoclonal antibody, the immunogenicity was reduced, and the antibody was replaced from IgG2 subtype to IgG1 subtype, and a flexible amino acid sequence was inserted between the CDR3 and CH2 regions of the heavy chain of the IgG1 antibody to reduce the immunogenicity. The purpose of ADCC/CDC function is to improve the stability of the antibody and prolong its half-life. The binding affinity of the monoclonal antibody of the invention to human C5 is similar to that of the original Eculizumab antibody, it can specifically block the complement hemolytic activity of C5 and the production of C5a and can be used for the preparation of C5-targeted paroxysmal nocturnal hemoglobinuria and atypical the drug for the treatment of hemolytic uremic syndrome has excellent clinical therapeutic value.

Abstract: A low-oxygen heating-type cigarette assembly, comprising a low-oxygen heating-type smoking set (B) and a low-oxygen heating-type cigarette (A). The low-oxygen heating-type smoking set (B) comprises a heating section (4) and a smoke extracting member (2) detachably arranged with the heating section (4), wherein the heating section (4) is provided with a cigarette receiving chamber (4-1), and the smoke extracting member (2) comprises a hollow smoke extracting cone (2-1) and a smoke transmission tube (2-2).

Abstract: The present disclosure provides a pad structure and a testkey structure and a testing method for a semiconductor device. The pad structure includes: an insulating dielectric layer formed on a substrate; a metal interconnection structure formed in the insulating dielectric layer, the metal interconnection structure comprising a first section and a second section, which are insulated from each other; and a pad formed on the top of the insulating dielectric layer so as to be exposed therefrom at least at its top surface, electrically connected to the first section, and insulated from the second section. With this disclosure, reduced capture of plasma is achievable, mitigating adverse impact of plasma on the semiconductor device.

Abstract: A semiconductor device and a method of fabricating same are disclosed. The semiconductor device includes: an SOI substrate including, stacked from the bottom upward, a lower substrate, a buried insulator layer and a semiconductor layer, wherein active regions surrounded by trench isolation structures are formed in the semiconductor layer; a gate electrode layer formed over the semiconductor layer, the gate electrode layer extending from active regions to trench isolation structures; and a source region and a drain region formed in the active regions that are on opposing sides of the gate electrode layer, wherein at least one end portion of the gate electrode layer laterally spans over interfaces of the active regions and the trench isolation structures toward the source region and/or the drain region. Thereby leakage at the interfaces of the active regions and the trench isolation structures can be reduced, resulting in improved performance of the semiconductor device.

Abstract: A computer device obtains a first face image (IMA) and a second face image (IFA). The device obtains M first image blocks corresponding to facial features from the first face image (IMA), and obtains N second image blocks corresponding to facial features from the second face image (IFA). The device transforms the M first image blocks and the N second image blocks to a feature space to generate M first feature blocks and N second feature blocks. The device selects a subset of the first feature blocks and a subset of the second feature blocks according to a specified control vector. The device generates a first composite feature map based the selected subset of the first feature blocks and the selected subset of the second feature blocks. The device inversely transforms the first composite feature map back to an image space to generate a third face image.

Abstract: A risk measurement method for a user account, a related apparatus, and an electronic device are applied to a zero trust architecture, to improve security of the zero trust architecture. The method includes: obtaining a user behavior log of a terminal device, determining a behavior feature of a first behavior type to which a user behavior recorded in the user behavior log belongs, and determining a first danger degree value of a user account based on the behavior feature of the first behavior type. In the method, a risk degree of the user account can be evaluated in time directly based on the behavior feature reflected in the user behavior log, and the risk degree does not need to be evaluated until a threat event is generated.

Abstract: The present disclosure relates to cyclic oligopeptides that bind to interleukin-13 (IL-13) which are useful therapeutically in methods of treating or preventing IL-13-associated skin disorders or conditions. The present disclosure also provides methods to treat or prevent IL-13-associated skin disorders or conditions with the IL-13-binding cyclic oligopeptides. The present disclosure further provides methods to produce the IL-13-binding cyclic oligopeptides.