Patents by Inventor Lelia Ng

Lelia Ng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia
    Patent number: 6080578
    Abstract: Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 27, 2000
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: James R. Bischoff, Julie Nye, Lelia Ng, Sharon Horn, Angelica Williams, David Kirn