Patents by Inventor Le SHEN

Le SHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260153454
    Abstract: The CT imaging system includes: an imaging channel; M distributed ray sources, at least one of which including q target spots; N detectors. The q target spots of the distributed ray source are arranged at intervals along a first straight line inclined relative to a first direction. The imaging method includes: placing an object to be imaged in the imaging channel; controlling q target spots of the distributed ray source to emit ray beams to form an imaging area; detecting, using the detector, a ray emitted from the distributed ray source and penetrating the object to be imaged, and generating projection data according to the detected ray; and generating a computed tomography image of the object to be imaged according to the projection data. The beam emitting time interval is determined based on an inclination angle of an extension direction of the first straight line relative to the first direction.
    Type: Application
    Filed: June 30, 2025
    Publication date: June 4, 2026
    Inventors: Zhiqiang CHEN, Li Zhang, Hongkai Yang, Changyu Chen, Qingping Huang, Le shen
  • Publication number: 20260153458
    Abstract: The CT imaging system includes: an imaging channel for placing an object to be imaged in an imaging process; M distributed X-ray sources arranged at intervals along a circumferential direction of the imaging channel, the distributed X-ray source including q target spots; N detectors arranged at intervals along the circumferential direction of the imaging channel, including first sub-detectors and second sub-detectors. The CT imaging system includes imaging components each including the distributed X-ray source and the first sub-detector. In the same imaging component, the distributed X-ray source and the first sub-detector are arranged face-to-face in a radial direction of the imaging channel, target spots of the distributed X-ray source and at least part of the first sub-detector are in a same plane perpendicular to the first direction. At least one second sub-detector is provided on at least one side of the distributed X-ray source in the first direction.
    Type: Application
    Filed: October 27, 2025
    Publication date: June 4, 2026
    Inventors: Zhiqiang CHEN, Li ZHANG, Hongkai YANG, Changyu CHEN, Qingping HUANG, Le SHEN
  • Publication number: 20250234323
    Abstract: The present disclosure provides a method and an apparatus of processing a positioning information, an electronic device, and a storage medium, which may be applied to a field of a positioning technology. The method includes: acquiring, in response to a positioning request, a distance information of each of a plurality of base stations for a terminal device; determining, based on a plurality of distance information, a first position information of the terminal device in a first reference system determined based on the plurality of base stations; and determining a positioning information of the terminal device for a target object based on the first position information and a position information of the target object, where the position information of the target object is determined from a tomography result.
    Type: Application
    Filed: July 19, 2023
    Publication date: July 17, 2025
    Inventors: Zhiqiang CHEN, Li ZHANG, Yunda SU N, Le SHEN, Zhipeng Pl, Shuo WANG
  • Publication number: 20250154110
    Abstract: Provided is a method of treating a disorder mediated by claudin-2 and/or claudin-15, particularly an intestinal disorder, such as colitis or enteritis. The method comprises administering to the subject an effective amount of a compound of formula (I), formula (II), or otherwise as described herein or a pharmaceutically acceptable salt thereof. In another aspect, also provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 2, 2022
    Publication date: May 15, 2025
    Applicants: The University of Chicago, The Board of Trustees of the University of Illinois
    Inventors: Christopher R. Weber, Le Shen, Fatemeh Khalili-Araghi
  • Publication number: 20250095240
    Abstract: A static CT apparatus and an imaging method for the same are provided. The imaging method includes: acquiring initial projection data of an inspected object at different angles by using a distributed ray source and a detector, where the initial projection data includes projection data that is directly obtained by the detector based on the rays emitted from a plurality of ray source points; obtaining a first CT image using a reconstruction algorithm according to the acquired initial projection data; dividing the first CT image into N first sub-images, where N is a positive integer greater than or equal to 1, and a union of the N first sub-images covers the entire first CT image; optimizing the N first sub-images to obtain N second sub-images; and merging the N second sub-images to obtain a second CT image.
    Type: Application
    Filed: August 31, 2023
    Publication date: March 20, 2025
    Inventors: Zhiqiang CHEN, Li ZHANG, Hu TANG, Yunda SUN, Xin JIN, Zhenhua ZHAO, Le SHEN
  • Patent number: 12188882
    Abstract: The method includes: receiving an encoder signal and a ray machine output beam signal, and initially synchronizing the encoder signal and the ray machine output beam signal; recording coded value M of the encoder at moment tm, and coded value N of the encoder at moment tm+1, where M, N, and m are integers; determining that duration from the moment tm to the moment tm+1 is an actual output beam time interval T of the ray machine, when it is determined that a difference value between the coded value M and the coded value N satisfies preset value a, a being an integer; determining gap time TG in the actual output beam time interval T based on a preset output beam time interval TJ of the imaging system and the actual output beam time interval T; and controlling the ray machine not to emit beam within the gap time TG.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: January 7, 2025
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Zhiqiang Chen, Li Zhang, Yunda Sun, Zhenhua Zhao, Xin Jin, Le Shen, Wuyang Liang
  • Publication number: 20240382596
    Abstract: The present invention relates to the technical field of medicine, and in particular, relates to a composition of vancomycin aqueous solution. The pharmaceutical composition contains vancomycin or a pharmaceutically acceptable salt thereof, N-methylalanine, and water. The stability of vancomycin in the state of an aqueous solution can be improved by using N-methylalanine.
    Type: Application
    Filed: June 21, 2022
    Publication date: November 21, 2024
    Applicants: HAINAN POLY PHARM. CO., LTD., ZHEJIANG POLY PHARMACEUTICAL CO., LTD.
    Inventors: Yifan ZHU, Minhua FAN, Ping LU, Zhenkun ZHAO, Cangsu XU, Hui SHI, Le SHEN
  • Publication number: 20240361487
    Abstract: A radiation protection arrangement, including: a housing, the housing including a first port and a second port; and a tray, the tray having an accommodation space. The tray is allowed to pass through a channel within the housing. The tray has a first end wall, a second end wall, and a bottom portion connected between the first end wall and the second end wall. A shape of the first end wall and/or a shape of the second end wall are/is configured to fit with an inner wall of the housing, so as to block a radiation from leaving the channel from the accommodation space through the second port or the first port. Further provided is a security inspection device, including the radiation protection arrangement.
    Type: Application
    Filed: July 22, 2022
    Publication date: October 31, 2024
    Inventors: Li ZHANG, Yunda SUN, Xin JIN, Wuyang LIANG, Ming CHANG, Le SHEN
  • Patent number: 11906447
    Abstract: A multi-channel static CT device is provided, and the multi-channel static CT device includes: a scanning channel including a plurality of scanning sub-channels; a distributed X-ray source including a plurality of ray emission points arranged around the scanning channel; and a detector module including a plurality of detectors arranged around the scanning channel, wherein the plurality of detectors are arranged corresponding to the plurality of ray emission points.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: February 20, 2024
    Assignees: NUCTECH COMPANY LIMITED, Tsinghua University
    Inventors: Zhiqiang Chen, Li Zhang, Xiaofei Xu, Le Shen, Ming Chang, Hu Tang, Xin Jin, Yunda Sun
  • Patent number: 11768163
    Abstract: The present application discloses a CT system and a detection apparatus for the CT system. The detection apparatus includes: a high-energy detector assembly including a plurality of rows of high-energy detectors arranged along a predetermined trajectory; a low-energy detector assembly including a plurality of rows of low-energy detectors arranged at intervals along the predetermined trajectory, the low-energy detector assembly and the high-energy detector assembly being disposed in a stack; a number of rows of the low-energy detectors is smaller than a number or rows of the high-energy detectors; and each row of the low-energy detectors covers a row of high-energy detectors.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: September 26, 2023
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Li Zhang, Zhiqiang Chen, Qingping Huang, Yunda Sun, Xin Jin, Le Shen, Liang Li, Tiao Zhao
  • Publication number: 20230144259
    Abstract: The method includes: receiving an encoder signal and a ray machine output beam signal, and initially synchronizing the encoder signal and the ray machine output beam signal; recording coded value M of the encoder at moment tm, and coded value N of the encoder at moment tm+1, where M, N, and m are integers; determining that duration from the moment tm to the moment tm+1 is an actual output beam time interval T of the ray machine, when it is determined that a difference value between the coded value M and the coded value N satisfies preset value a, a being an integer; determining gap time TG in the actual output beam time interval T based on a preset output beam time interval TJ of the imaging system and the actual output beam time interval T; and controlling the ray machine not to emit beam within the gap time TG.
    Type: Application
    Filed: November 4, 2022
    Publication date: May 11, 2023
    Inventors: Zhiqiang CHEN, Li ZHANG, Yunda SUN, Zhenhua ZHAO, Xin JIN, Le SHEN, Wuyang LIANG
  • Publication number: 20220091051
    Abstract: A multi-channel static CT device is provided, and the multi-channel static CT device includes: a scanning channel including a plurality of scanning sub-channels; a distributed X-ray source including a plurality of ray emission points arranged around the scanning channel; and a detector module including a plurality of detectors arranged around the scanning channel, wherein the plurality of detectors are arranged corresponding to the plurality of ray emission points.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 24, 2022
    Inventors: Zhiqiang CHEN, Li ZHANG, Xiaofei XU, Le SHEN, Ming CHANG, Hu TANG, Xin JIN, Yunda SUN
  • Publication number: 20220042929
    Abstract: The present application discloses a CT system and a detection apparatus for the CT system. The detection apparatus includes: a high-energy detector assembly including a plurality of rows of high-energy detectors arranged along a predetermined trajectory; a low-energy detector assembly including a plurality of rows of low-energy detectors arranged at intervals along the predetermined trajectory, the low-energy detector assembly and the high-energy detector assembly being disposed in a stack; a number of rows of the low-energy detectors is smaller than a number or rows of the high-energy detectors; and each row of the low-energy detectors covers a row of high-energy detectors.
    Type: Application
    Filed: September 10, 2019
    Publication date: February 10, 2022
    Applicants: Nuctech Company Limited, Tsinghua University
    Inventors: Li ZHANG, Zhiqiang CHEN, Qingping HUANG, Yunda SUN, Xin JIN, Le SHEN, Liang Ll, Tiao ZHAO
  • Patent number: 10984565
    Abstract: An image processing method, comprising: acquiring, by a CT scanning system, projection data of an object; and processing, by using a convolutional neural network, the projection data, to acquire an estimated image of the object. The convolutional neural network comprises: a projection domain network for processing input projection data to obtain estimated projection data; an analytical reconstruction network layer for performing analytical reconstruction to obtain a reconstructed image; an image domain network for processing the reconstructed image to obtain an estimated image, a projection layer for performing a projection operation by using a system projection matrix of the CT scanning system, to obtain a projection result of the estimated image; and a statistical model layer for determining consistency among the input projection data, the estimated projection data, and the projection result of the estimated image based on a statistical model.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: April 20, 2021
    Assignees: Tsinghua University, NUCTECH COMPANY LIMITED
    Inventors: Yuxiang Xing, Kaichao Liang, Le Shen, Li Zhang, Hongkai Yang, Kejun Kang, Zhiqiang Chen, Jianmin Li, Yinong Liu
  • Patent number: 10724969
    Abstract: An X-ray detection method and an X-ray detector are provided. The X-ray detection method according to embodiments of the present disclosure includes: dividing an energy range of photons emitted by an X-ray source into a number N of energy windows, where N is an integer greater than 0; obtaining a weighting factor for each of the number N of energy windows based on linear attenuation coefficients of a substance of interest and a background substance of an imaging target; obtaining a weighting factor matrix for M output channels of an X-ray detector based on the weighting factor for each of the number N of energy windows, where M is an integer greater than 0; and obtaining output results of the M output channels based on the weighting factor matrix and numbers of photons having an energy range falling into individual energy windows of the number N of energy windows.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: July 28, 2020
    Assignees: NUCTECH COMPANY LIMITED, TSINGHUA UNIVERSITY
    Inventors: Yuxiang Xing, Xiaoyue Guo, Zhi Deng, Le Shen, Li Zhang, Zhiqiang Chen, Liang Li
  • Patent number: 10643759
    Abstract: The disclosure relates to a grating and a radiation imaging device. The grating comprises a plurality of stacked grating elements. The grating elements are stacked to form a grid. The grating element comprises a first sheet and a second sheet having two parallel planes. The second sheet is stacked at the first sheet in a length direction of the first sheet. The first sheet is almost impervious to radiation. The present disclosure stacks the sheets having different specifications together to form the grating with uniform grating slits, such that there is no limitation on the thickness of the grating and the grating can be used along with high-energy radiations.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: May 5, 2020
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Li Zhang, Mingzhi Hong, Qingping Huang, Le Shen
  • Patent number: 10641715
    Abstract: An X-ray imaging system and method are provided. The system may include: an X-ray source configured to irradiate X-ray beams; a first grating and a second grating arranged sequentially in an irradiation direction of the X-ray beams; a detector arranged at downstream of the second grating in the irradiation direction; and a controller and data processing device configured to control the X-ray source to irradiate the X-ray beams, to control the detector to receive X-ray beams passing through the first grating and the second grating to generate phase contrast information and/or dark field information, and to perform CT check on an object under check based on the phase contrast information and/or the dark field information to obtain a CT image. In this way, it is possible to obtain more characteristic information about the object under check, so as to achieve more precise material recognition and security check.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: May 5, 2020
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Zhiqiang Chen, Li Zhang, Le Shen, Qingping Huang, Xin Jin
  • Patent number: 10634810
    Abstract: The disclosure provides a scanning imaging system for security inspection of an object and an imaging method thereof, the system comprising: a conveying unit configured for bringing the object to move along a conveying direction; a plurality of radiographic sources at one side of the conveying unit, being arranged successively in a direction vertical to a plane, in which the conveying unit is located, and configured for alternately emitting ray beams to form a scanning area; a linear detector array at the other side of the conveying unit, being configured for detecting first projection images, which are formed after the ray beams emitted by the plurality of radiographic sources penetrate through the object, in the process of the object passing through the scanning area; an imaging unit configured for obtaining a first reconstructed image of the object based on the first projection images of the plurality of radiographic sources.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: April 28, 2020
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Li Zhang, Zhiqiang Chen, Le Shen, Qingping Huang, Yunda Sun, Xin Jin, Hui Ding, Yuxiang Xing
  • Patent number: 10489939
    Abstract: A spectral CT image reconstructing method includes: collecting incomplete original projection data in each of a plurality of energy windows; performing a projection data cross estimation using corresponding original projection data in at least one pair of energy windows constituted by different energy windows of the plurality of energy windows to obtain estimated projection data, wherein each pair of energy windows comprises a first energy window and a second energy window; combining the original projection data and the corresponding estimated projection data to obtain complete projection data; and reconstructing a spectral CT image using the complete projection data.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: November 26, 2019
    Assignees: TSINGHUA UNIVERSITY, NUCTECH COMPANY LIMITED
    Inventors: Yuxiang Xing, Li Zhang, Huayu Zhang, Le Shen
  • Publication number: 20190206095
    Abstract: An image processing method, comprising: acquiring, by a CT scanning system, projection data of an object; and processing, by using a convolutional neural network, the projection data, to acquire an estimated image of the object. The convolutional neural network comprises: a projection domain network for processing input projection data to obtain estimated projection data; an analytical reconstruction network layer for performing analytical reconstruction to obtain a reconstructed image; an image domain network for processing the reconstructed image to obtain an estimated image, a projection layer for performing a projection operation by using a system projection matrix of the CT scanning system, to obtain a projection result of the estimated image; and a statistical model layer for determining consistency among the input projection data, the estimated projection data, and the projection result of the estimated image based on a statistical model.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 4, 2019
    Inventors: Yuxiang XING, Kaichao LIANG, Le SHEN, Li ZHANG, Hongkai YANG, Kejun KANG, Zhiqiang CHEN, Jianmin LI, Yinong LIU