Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: The compound as shown in formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof, and a preparation method therefor, and the use thereof as an MAT2A inhibitor. Ring A, ring Q, X, Y, X1, X2, L and R1 in formula (I) are as defined in the description.

Abstract: Fault interrupting devices and methods for controlling the same are disclosed. The fault interrupting devices may include a switch on an electrical power line and a controller configured to operate the switch. The methods for controlling fault interrupting devices may include gathering data, determining from the data that a fault has occurred, opening the fault interrupting device to interrupt the fault, analyzing the data, and determining whether the fault interrupting device can be reclosed based at least partially on the analysis of the data.

Abstract: The present disclosure provides an X-ray backscattering safety inspection system, comprising: one or more backscattering inspection subsystem configured to inspect an object to be inspected by emitting X-ray beams towards the object to be inspected and inspecting scattering signals; and a control subsystem configured to adjust a distance between the backscattering inspection subsystem and locations on a side of the object to be inspected where are irradiated by the X-ray beams in real time according to a size of the object to be inspected such that the scattering signals inspected are optimized. The system may be adapted to objects to be inspected with different sizes or shapes while enhancing backscattering signals for imaging.

Abstract: The present disclosure provides a mobile back scattering imaging security inspection apparatus, comprising: a back scattering scanner (2), a detector (3), a controller (4), and a movable stage (1) configured to carry the back scattering scanner, the detector and the controller and being movable with respect to the object to be inspected; wherein the back scattering scanner is a distributed X-ray source comprising a plurality of target points (201), each of which is able to emit the ray beam individually, and wherein the back scattering scanner, the detector and the controller perform an imaging security inspection operation on the object to be inspected during moving along with the movable stage with respect to the object.

Abstract: The present disclosure provides an X-ray generator with adjustable collimation. The X-ray generator comprises: an assembly of X-ray source, which includes an X-ray tube having a cathode and an anode and a front collimator; a high voltage generator, which is disposed in an extended chamber of a housing for the X-ray tube and which is used for supplying a direct current high voltage between the cathode and the anode of the X-ray tube to excite X-ray beams; a collimation adjustment unit, which is rotatably disposed outside of the front collimator and which is used for adjusting fan-type X-ray beams into continuous pencil-type X-ray beams; and a cooling unit, which is independently mounted to the X-ray tube and which is used for cooling the anode of the X-ray tube; wherein, the assembly of X-ray source, the high voltage generator, the collimation adjustment unit and the cooling unit are integrated as a whole.

Abstract: A hybrid transformer is provided that includes an electromagnetic transformer and an AC-AC converter with a DC bridge. The AC-AC converter is operable to keep the input voltage and current of the hybrid transformer substantially in phase and to reduce fluctuation in the output voltage of the hybrid transformer in the event of an increase or decrease in the input voltage.

Abstract: A method is disclosed for preventing malicious settings changes to IEDs in a power transmission and distribution network. Attempted changes to the protection settings of an IED is detected and transmitted to one or more neighboring IEDs. The neighboring IEDs check for consistency of the new settings and return conformance or nonconformance signals. If a nonconformance signal is received, the attempted setting change is not allowed.

Abstract: The present disclosure provides a human body security inspection system, including: an X-ray source configured to provide X-ray radiation for scanning a human body to be inspected, a detector configured to receive X-ray radiation transmitting through the human body to be inspected and generate a transmission signal, a sensor configured to obtain the weight of the human body to be inspected, a carrying device configured to carry and move the human body to be inspected in a direction such that the human body is scanned, and a controller configured to receive a signal from the sensor, determine the weight of the human body to be inspected based on the signal from the sensor, and determine and control a voltage and/or current applied to the X-ray source and a movement speed of the carrying device according to the weight.

Abstract: The present disclosure relates to a portable backscatter imaging inspection apparatus and an imaging method thereof, the apparatus comprising: an apparatus housing, an X-ray source, a rotating modulation mechanism, a radiation detector, a motion sensor and a controller; the X-ray source, the rotating modulation mechanism, the radiation detector and the motion sensor are disposed within the apparatus housing, wherein the radiation detector is used to receive scatter signal data from a surface of an object under inspection to form a two dimensional (2D) image, the motion sensor is used to collect a three dimensional (3D) motion track and scanning angles of the apparatus during a scanning process, the controller is used to splice and fuse a plurality of 2D images received by the radiation detector based on the 3D motion track and the scanning angles to obtain a stereo image of the surface of the object under inspection.

Abstract: A human body back-scattering inspection method and system are discloses. The method includes: obtaining a back-scattering scan image of a human body under inspection; distinguishing a body image from a background image in the back-scattering scan image; and calculating a feature parameter of the background image to determine whether radioactive substance is carried with the human body. With some embodiments of the present disclosure, it is possible to determine whether any radioactive substance is carried with a human body during back-scattering inspection of the human body. In further embodiments of the present disclosure, it is possible to approximately determine which part(s) of the human body carries the radioactive substance. This improves efficiency of inspection.

Abstract: The present invention provides a human body security inspection method and system. The method comprises: retrieving in real-time scanning row or column image data of a personal to be inspected; transmitting in real-time the image data to an algorithm processing module and processing these image data by the module; automatically recognizing a suspicious matter by a suspicious matter automatic target recognition technique, after retrieving an image data of an entire scanning image of the personal; any of the following three inspection modes is selected, so as to perform a further processing on basis of the recognition result of the suspicious matter, (1) in a manner of automatic target recognition technique, (2) in a combination manner of the automatic target recognition technique and a privacy protection image; and (3) a combination manner of the automatic target recognition technique, a privacy protection image and human intervention.

Abstract: A hybrid distribution transformer is provided that includes an electromagnetic transformer and a voltage source converter that is operable to reduce fluctuation in the output voltage of the hybrid distribution transformer in the event of an increase or decrease in the input voltage.

Abstract: A human body back-scattering inspection system is disclosed. The system comprises a flying-spot forming unit configured to output beams of X-rays, a plurality of discrete detectors which are arranged vertically along a human body to be inspected, and a controlling unit coupled to the flying-spot forming unit and the plurality of detectors, and configured to generate a control signal to control the flying-spot forming unit and the plurality of detectors to perform a partition synchronous scan on the human body to be inspected vertically. The present disclosure utilizes the geometry property of the human body back-scattering inspection system, and proposes a multiple-point synchronous scan mechanism which largely accelerates the inspection of human body.

Abstract: Disclosed is an integrated flying-spot X-ray apparatus comprising a ray generator configured to generate the X-ray, a revolving collimator device provided thereon with at least one aperture and arranged to be rotatable about the ray generator, a frameless torque motor configured to drive the revolving collimator device to rotate about the ray generator, and a cooling device configured to cool the ray generator, wherein the ray generator, the revolving collimator device, the frameless torque motor and the cooling device are mounted on an integrated mounting frame. Compared with the prior art, the integrated flying-spot X-ray apparatus according to the present disclosure has a simple and compact structure and is used as a kernel apparatus for fields of safety inspection and medical treatment.

Abstract: The invention presents a backscattering scintillation detector. The scintillation detector includes a scintillation crystal detector; a X-ray sensitizing screen, which is disposed forward the scintillation crystal detector and where a backscattered X-ray from an object to be detected is processed and then at least part of the processed X-ray is incident to scintillation crystal detector; and photoelectric multiplier, which is disposed backward the scintillation crystal detector and is configured to collect a light signal from scintillation crystal detector and convert it to an electrical signal. Through the above preferable embodiment, a X-ray sensitizing screen, a scintillation crystal detector, and light guiding and wave-drifting technologies are combined together to obtain a novel scintillation detector, which can improve detection of X-ray, transmission of light signal and conversion of light signal to electrical signal.

Abstract: Human body back-scattering inspection systems and methods are disclosed. In the invention, X-rays modulated by the flying-spot forming unit having spirally distributed flying-spots have a distribution having alternating peaks and valleys on the irradiated surface. In this way, scanning starting times can be precisely controlled to cause two devices to have scanning starting times that are different by a half of a cycle. That is, the beams outputted from one device are at maximum when the beams outputted from the other device are at minimum. In other words, even if the ray source of one device emits rays, it will not significantly affect imaging result of the other device. In such way, the two devices may emit rays and perform scanning at the same time, and thus the total scanning time is reduced.

Abstract: The present disclosure provides an X-ray backscattering safety Inspection system, comprising: one or more backscattering inspection subsystem configured to inspect an object to be inspected by emitting X-ray beams towards the object to be inspected and inspecting scattering signals; and a control subsystem configured to adjust a distance between the backscattering inspection subsystem and locations on a side of the object to be inspected where are irradiated by the X-ray beams in real time according to a size of the object to be inspected such that the scattering signals inspected are optimized. The system may be adapted to objects to be inspected with different sizes or shapes while enhancing backscattering signals for imaging.

Abstract: The present disclosure provides a mobile back scattering imaging security inspection apparatus, comprising: a back scattering scanner (2), a detector (3), a controller (4), and a movable stage (1) configured to carry the back scattering scanner, the detector and the controller and being movable with respect to the object to be inspected; wherein the back scattering scanner is a distributed X-ray source comprising a plurality of target points (201), each of which is able to emit the ray beam individually, and wherein the back scattering scanner, the detector and the controller perform an imaging security inspection operation on the object to be inspected during moving along with the movable stage with respect to the object.

Abstract: The present invention provides an X-ray backscattering safety inspection system, comprising: an X-ray source comprising a plurality of target spots each individually controllable to emit X-rays; collimators configured to be respectively passed through the X-ray emitted from the plurality of target spots and output N pencil-shaped X-ray beams, and the N pencil-shaped X-ray beams are irradiated onto N locations of an object to be inspected; and N detectors configured to respectively receive scattering signals from the corresponding locations of the object to be inspected, in which N is a positive integer that is great than or equal to 2. The system may achieve double scannings in one scanning operation, which not only increases scanning speed but also enhances backscattering signal for imaging.