Abstract: The compositions and methods described herein are directed to treating solid tumors using CAR T therapy and/or antibodies targeting GCC. The compositions include CAR comprising an extracellular domain that binds GCC.

Abstract: The present disclosure discloses an acoustic device and a method for determining a transfer function thereof. The acoustic device includes a sound production unit, a first detector, a processor, and a fixing structure. The sound production unit is configured to generate a first sound signal based on a noise reduction control signal. The first detector is configured to obtain a first residual signal including a residual noise signal formed by superposition of an environmental noise and the first sound signal at a location of the first detector. The processor is configured to estimate a second residual signal at a target spatial location that is closer to the ear canal than the first detector, and update the noise reduction control signal based on the second residual signal. The fixing structure is configured to place the acoustic device at a location near a user's ear but not blocking the ear canal.

Abstract: The present disclosure relates to compositions and methods for enhancing infiltration of lymphocytes into tumor tissue, enhancing anti-tumor lymphocyte activities in tumor microenvionment (TME), inhibiting regulatory lymphocyte (e.g., B and T cells) activities in TME, and/or long term benefit of cell therapies. For example, in a method of in vivo cell expansion, the method comprises administering an effective amount of cells comprising an antigen binding molecule to a subject; and administering an effective amount of presenting cells expressing a solid tumor antigen that the binding molecule binds.

Abstract: Microphone signals output by the microphone array satisfy a first model corresponding to a noise signal or a second model corresponding to a target voice signal mixed with a noise signal. A method and system may optimize the first model and the second model respectively by using maximization of a likelihood function and rank minimization of a noise covariance matrix as joint optimization objectives, and determine a first estimate of a noise covariance matrix of the first model and a second estimate of a noise covariance matrix of the second model; and determine, by using a statistical hypothesis testing method, whether the microphone signals satisfy the first model or the second model, so as to determine whether the target voice signal is present in the microphone signals, determine a noise covariance matrix of the microphone signals, and further perform voice enhancement on the microphone signals.

Abstract: A voice activity detection method and system and a voice enhancement method and system are provided. A voice presence probability of a target voice signal present in microphone signals may be determined by calculating a linear correlation between a signal subspace where the microphone signals are located and a target subspace where the target voice signal is located. The voice enhancement method and system may be used to calculate filter coefficients based on the voice presence probability, so as to perform voice enhancement on the microphone signals. The calculation accuracy of the voice presence probability is improved, and the voice enhancement effect is also improved.

Abstract: The present disclosure provides a method for voice enhancement, including: obtaining a first signal and a second signal of a target voice, the first signal being a signal of the target voice collected based on a first position, and the second signal being a signal of the target voice collected based on a second position; determining a first coefficient by processing, based on a position of the target voice, the first position, and the second position, the first signal and the second signal; determining, based on the first signal and the second signal, a plurality of parameters related to a plurality of sound source directions; determining, based on the plurality of parameters and the position of the target voice, a second coefficient; and obtaining a voice-enhanced first output voice signal corresponding to the target voice by processing the first signal and/or the second signal.

Abstract: One or more embodiments of the present disclosure relates to hearing aids. A hearing aid includes a plurality of microphones configured to receive an initial sound signal and convert the initial sound signal into an electrical signal; a processor configured to process the electrical signal and generate a control signal; and a speaker configured to convert the control signal into a hearing aid sound signal. To process the electrical signal and generate the control signal, the processor is configured to: adjust a directivity of the initial sound signal received by the plurality of microphones, so that a sound intensity of a first sound signal from a direction of the speaker in the initial sound signal is always greater than or always less than a sound intensity of a second sound signal from other directions around.

Abstract: The embodiments of the present disclosure provide a method and system for voice enhancement, including: obtaining a first signal and a second signal of a target voice, the first signal and the second signal being voice signals of the target voice at different voice collection positions; determining a target signal-to-noise ratio (SNR) of the target voice based on the first signal or the second signal; determining a processing mode for the first signal and the second signal based on the target SNR; and processing the first signal and the second signal based on the determined processing mode to obtain a voice-enhanced output voice signal corresponding to the target voice.

Abstract: The present disclosure provides an acoustic device including a microphone array, a processor, and at least one speaker. The microphone array may be configured to acquire an environmental noise. The processor may be configured to estimate a sound field at a target spatial position using the microphone array. The target spatial position may be closer to an ear canal of a user than each microphone in the microphone array. The processor may be configured to generate a noise reduction signal based on the environmental noise and the sound field estimation of the target spatial position. The at least one speaker may be configured to output a target signal based on the noise reduction signal. The target signal may be used to reduce the environmental noise. The microphone array may be arranged in a target area to minimize an interference signal from the at least one speaker to the microphone array.

Abstract: An open acoustic device (100) may include a fixing structure (120) configured to fix the acoustic device (100) near an ear of a user without blocking an ear canal of the user; a first microphone array (130) configured to acquire environmental noise (410); a signal processor (140) configured to: determine, based on the environmental noise, a primary route transfer function (420) between the first microphone array (130) and the ear canal of the user; estimate, based on the environmental noise and the primary route transfer function, a noise signal (430) at the ear canal of the user; and generate, based on the noise signal at the ear canal of the user, a noise reduction signal (440); and a speaker (150) configured to output, according to the noise reduction signal, a noise reduction acoustic wave (450), the noise reduction acoustic wave being configured to eliminate the noise signal.

Abstract: The present disclosure provides a method and system for determining a speech presence probability, a speech enhancement method and system, and a headphone. The speech presence probability and a speech absence probability in an iteration operation may be corrected by comparing an entropy of the speech presence probability and an entropy of a speech absence probability, such that a faster convergence speed and better convergence results may be obtained, thereby improving accuracy of an estimation of the speech presence probability and an accuracy of an estimation of a noise spatial covariance matrix, and then improving a speech enhancement effect of a minimum variance distortionless response (MVDR).

Abstract: The present disclosure provides an acoustic device including a microphone array, a processor, and at least one speaker. The microphone array may be configured to acquire an environmental noise. The processor may be configured to estimate a sound field at a target spatial position using the microphone array. The target spatial position may be closer to an ear canal of a user than each microphone in the microphone array. The processor may be configured to generate a noise reduction signal based on the environmental noise and the sound field estimation of the target spatial position. The at least one speaker may be configured to output a target signal based on the noise reduction signal. The target signal may be used to reduce the environmental noise. The microphone array may be arranged in a target area to minimize an interference signal from the at least one speaker to the microphone array.

Abstract: Some embodiments of the present disclosure provide a method for locating a vibration signal source. The method may include obtaining sensing signals of at least two vibration sensing devices located at different locations, each of the sensing signals being generated by one of the at least two vibration sensing devices by sensing a vibration signal generated by a vibration, which is from the same vibration signal source; determining, based on the sensing signals, a time difference between time points when the at least two vibration sensing devices located at different locations receive the vibration signal; and determining, based on the time difference, a location of the vibration signal source.

Abstract: An open acoustic device (100) may include a fixing structure (120) configured to fix the acoustic device (100) near an ear of a user without blocking an ear canal of the user; a first microphone array (130) configured to acquire environmental noise (410); a signal processor (140) configured to: determine, based on the environmental noise, a primary route transfer function (420) between the first microphone array (130) and the ear canal of the user; estimate, based on the environmental noise and the primary route transfer function, a noise signal (430) at the ear canal of the user; and generate, based on the noise signal at the ear canal of the user, a noise reduction signal (440); and a speaker (150) configured to output, according to the noise reduction signal, a noise reduction acoustic wave (450), the noise reduction acoustic wave being configured to eliminate the noise signal.

Abstract: Embodiments of the present disclosure disclose an earphone including a fixing structure, a first microphone array, a processor, and a speaker. The fixing structure is configured to fix the earphone near a user's ear without blocking the user's ear canal and including a hook-shaped component and a body part. The first microphone array is located in the body part and is configured to pick up environmental noise. The processor is located in the hook-shaped component or the body part and is configured to estimate a sound field at a target spatial position using the first microphone array and generate a noise reduction signal based on the estimated sound field. The target spatial position is closer to the user's ear canal than any microphone in the first microphone array. The speaker is located in the body part and is configured to output a target signal according to the noise reduction signal.

Abstract: The invention employs a folding arm conveyor that rotates horizontally. The folding arm conveyor is mainly composed of an undercarriage mounted on the ground of a stockyard, a tower body mounted on the undercarriage, a balance arm, a conveying arm, a tower top, and other main components, wherein the balance arm, the conveying arm, and the tower top are mounted on the tower body. The conveying arm is provided with two portal frames (I) and (II) and an unloading trolley. The tower body is provided with a gyration apparatus and a hopper. The balance arm is provided with a balance trolley. The folding arm conveyor can rotate horizontally, and the conveying arm can be folded and retraced by controlling the wind rope by the windlass, so that the folding arm conveyor can be prevented from colliding with other devices or buildings during the rotation.

Abstract: The present disclosure provides an acoustic device including a microphone array, a processor, and at least one speaker. The microphone array may be configured to acquire an environmental noise. The processor may be configured to estimate a sound field at a target spatial position using the microphone array. The target spatial position may be closer to an ear canal of a user than each microphone in the microphone array. The processor may be configured to generate a noise reduction signal based on the environmental noise and the sound field estimation of the target spatial position. The at least one speaker may be configured to output a target signal based on the noise reduction signal. The target signal may be used to reduce the environmental noise. The microphone array may be arranged in a target area to minimize an interference signal from the at least one speaker to the microphone array.

Abstract: The invention employs a folding arm conveyor that rotates horizontally. The folding arm conveyor is mainly composed of an undercarriage mounted on the ground of a stockyard, a tower body mounted on the undercarriage, a balance arm, a conveying arm, a tower top, and other main components, wherein the balance arm, the conveying arm, and the tower top are mounted on the tower body. The conveying arm is provided with two portal frames (I) and (II) and an unloading trolley. The tower body is provided with a gyration apparatus and a hopper. The balance arm is provided with a balance trolley. The folding arm conveyor can rotate horizontally, and the conveying arm can be folded and retraced by controlling the wind rope by the windlass, so that the folding arm conveyor can be prevented from colliding with other devices or buildings during the rotation.

Abstract: The present disclosure provides an acoustic device including a microphone array, a processor, and at least one speaker. The microphone array may be configured to acquire an environmental noise. The processor may be configured to estimate a sound field at a target spatial position using the microphone array. The target spatial position may be closer to an ear canal of a user than each microphone in the microphone array. The processor may be configured to generate a noise reduction signal based on the environmental noise and the sound field estimation of the target spatial position. The at least one speaker may be configured to output a target signal based on the noise reduction signal. The target signal may be used to reduce the environmental noise. The microphone array may be arranged in a target area to minimize an interference signal from the at least one speaker to the microphone array.