Abstract: One example provides a computing system configured to provide scalable, real-time duplex communications across a data network, the computing system comprising one or more processors, and storage comprising instructions executable by the one or more processors to instantiate one or more real-time duplex communication service instances. Each real-time duplex communication service instance comprises a real-time duplex communication framework comprising a client hub configured to receive connections for a plurality of clients and a server hub configured to receive connections for a plurality of servers, and each real-time duplex communication service instance is configured to publish messages regarding a state of the real-time duplex communication framework to a channel accessed by other real-time duplex communication service instances.

Abstract: An anti-human PD-1 monoclonal antibody, and a preparation method therefor and an application thereof. The anti-human PD-1 monoclonal antibody has good bioactivity, can effectively bind with an extracellular region of a human PD-1 protein receptor, and can effectively seal PD-1 protein at protein level and cellular level and block the binding of the PD-1 protein with a ligand PD-L1, thereby effectively enhancing immunity. The monoclonal antibody can be applied independently or jointly with other antitumor drugs to tumor immunotherapy and the diagnosis and screening of patients with PD-L1 positive tumors; and the monoclonal antibody has a promising prospect in the preparation of drugs for treating tumors, resisting autoimmune diseases and the like.

Abstract: The present disclosure discloses a gas mixing device and a gas water heating device. In which, a gas mixing device, comprises: a shell provided with a fuel gas channel for inputting fuel gas, an air channel for inputting air and a gas mixing channel, the fuel gas channel being provided with a first cut-off portion capable of changing a flow area, and the air channel being provided with a second cut-off portion capable of changing a flow area; a moving part movable in the shell, the moving part simultaneously changing the flow areas of the first cut-off portion and the second cut-off portions by moving. The gas mixing device and the gas water heating device can provide a higher regulation ratio, thereby solving the problem that the water temperature is too high in summer.

Abstract: A gas replacement process and a gas replacement apparatus are employed, in the nitro compound hydrogenation reaction process. The gas replacement process at least includes a first step of subjecting a stream to be replaced to the gas replacement in presence of a first replacement gas, and then a second step of subjecting to the gas replacement in presence of the second replacement gas. Assuming the superficial velocity of the first replacement gas is V1, and the superficial velocity of the second replacement gas is V2, then V2/V1?1.5.

Abstract: A fluidized apparatus contains a double-trapezoid structural member. These fluidized apparatuses are used in the nitro compound hydrogenation reaction process. The fluidized apparatus includes a shell, a gas distributor, and an inner chamber defined by an inner wall of said shell and an upper surface of said gas distributor, in the middle region of said inner chamber is disposed a perforated plate, the perforated plate comprise an outer edge region and a center region, assuming the opening rate of the outer edge region is A1 (the unit is %), assuming the opening rate of the center region is A2 (the unit is %), then A1/A2=0-0.95.

Abstract: The present invention relates to a nitro compound hydrogenation reaction process and hydrogenation reaction apparatus, which can achieve the objects of the continuous reaction of the nitro compound and the long-period run of regeneration and activation. The nitro compound hydrogenation reaction process comprises a hydrogenation step, a regeneration step, an optional activation step and a recycling step. There exists at least one step of degassing the spent catalyst between the hydrogenation step and the regeneration step. According to circumstances, there exists at least one step of degassing the regenerated catalyst between the regeneration step and the activation step.

Abstract: The present invention relates to multi-substituted pyridone derivatives and therapeutic use thereof. In particular, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, as well as use thereof as a tyrosine kinase inhibitor, in particular, use thereof in treating a disease associated with tyrosine kinase activity. Each substituent in the formula (I) is defined as in the specification.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Abstract: Provided is an antibody binding to human HER2 or an antigen-binding fragment thereof capable of specifically binding to human HER2. Compared with Perjeta, the combination of the antibody or an antigen-binding fragment thereof and Herceptin has improved biological activity in inhibiting the proliferation of tumor cells overexpressing HER2. The antibody or an antigen-binding fragment thereof has an antigen-binding epitope different from known antibodies binding to human HER2, can be used to prepare a drug for treating a disease related to HER2 overexpression, such as cancer, and has good prospects for clinical application.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Abstract: The present invention relates to a preheating process and a start-up process for the ammoxidation reaction. The preheating process or the start-up process at least includes the step of heating the catalyst bed in the ammoxidation reactor while controlling the reactor operation linear speed to 0.03-0.15 m/s. The start-up process of the present invention has the advantages such as the significantly reduced launch time compared with the prior art and the operation safety.

Abstract: One example provides a computing system configured to provide scalable, real-time duplex communications across a data network, the computing system comprising one or more processors, and storage comprising instructions executable by the one or more processors to instantiate one or more real-time duplex communication service instances. Each real-time duplex communication service instance comprises a real-time duplex communication framework comprising a client hub configured to receive connections for a plurality of clients and a server hub configured to receive connections for a plurality of servers, and each real-time duplex communication service instance is configured to publish messages regarding a state of the real-time duplex communication framework to a channel accessed by other real-time duplex communication service instances.

Abstract: A feed gas feeding system for a propylene ammoxidation reactor comprises a feed gas mixing system and a feed distributor, wherein a propylene and ammonia mixed gas is mixed by the feed gas mixing system and then uniformly distributed in the propylene ammoxidation reactor by the feed distributor. The initial temperature T0 when the propylene and ammonia mixed gas enters the feed distributor is 10-220° C. The feed gas feeding system can prevent the temperature of the gas mixture at any position in the feed distributor from reaching a temperature at which ammonia decomposes into active nitrogen atoms, thereby reducing a risk of brittle nitriding fractures of the feed distributor.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Abstract: A laser diode device includes: a heat sink including a main body portion and an electrical insulating layer on the main body portion; a mounting layer on the electrical insulating layer, in which the mounting layer includes a first mounting pad and a second mounting pad electrically isolated from one another; a laser diode bar on the first mounting pad; a contact bar on the second mounting pad; a first solder layer providing an electrical connection between the contact bar and the second mounting pad; and multiple wire bonds providing an electrical connection from a top surface of the laser diode bar to a top surface of the contact bar.

Abstract: An anti-human PD-1 monoclonal antibody, and a preparation method therefor and an application thereof. The anti-human PD-1 monoclonal antibody has good bioactivity, can effectively bind with an extracellular region of a human PD-1 protein receptor, and can effectively seal PD-1 protein at protein level and cellular level and block the binding of the PD-1 protein with a ligand PD-L1, thereby effectively enhancing immunity. The monoclonal antibody can be applied independently or jointly with other antitumor drugs to tumor immunotherapy and the diagnosis and screening of patients with PD-L1 positive tumors; and the monoclonal antibody has a promising prospect in the preparation of drugs for treating tumors, resisting autoimmune diseases and the like.

Abstract: A fluid distributor includes one or more fluid transport main pipe. The fluid transport main pipe is configured to assume a closed shape when its centerlines and/or centerline extensions are joined end-to-end. Each of the fluid transport main pipe has at least one fluid inlet and is connected with a plurality of fluid transport branch pipes. Each of the fluid transport branch pipes has a plurality of open pores disposed along the length of the fluid transport branch pipe and a connection portion. The connection portion is configured to connect the fluid transport branch pipe to the housing after the fluid transport branch pipe passes through the housing of the vessel into the inner cavity.

Abstract: The present invention provides a feed gas feeding system for a propylene ammoxidation reactor. The feed gas feeding system comprises a feed gas mixing system and a feed distributor. A propylene and ammonia mixed gas is mixed by the feed gas mixing system and then uniformly distributed in the propylene ammoxidation reactor by means of the feed distributor, an initial temperature T0 when the propylene and ammonia mixed gas enters the feed distributor being 10-220° C. The propylene and ammonia feed gas feeding system of the present invention for ammoxidation of propylene and the preparation of acrylonitrile prevents the temperature of a gas mixture at any position in the propylene and ammonia feed distributor from reaching a temperature at which ammonia decomposes into active nitrogen atoms, thereby reducing a risk of brittle nitriding fractures of the propylene and ammonia distributor.