Patents by Inventor Leah Bar-Oz

Leah Bar-Oz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20160324943
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 26, 2015
    Publication date: November 10, 2016
    Applicant: TEVA PHARMACEUTICALS USA, INC.
    Inventors: Avi TOVI, Chaim EIDELMAN, Shimon SHUSHAN, Alon HAGI, Alexander IVCHENKO, Gabriel-Marcus BUTILCA, Leah BAR-OZ, Tehila GADI, Gil ZAOVI
  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20100273982
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 5, 2009
    Publication date: October 28, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20100029916
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 4, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • High purity peptides
    Publication number: 20080287650
    Abstract: The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing about 0.05% to about 0.5% [D-His]-Nesiritide (SEQ. ID NO. 1) as measured by chiral GC/MS.
    Type: Application
    Filed: March 3, 2008
    Publication date: November 20, 2008
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaoui, Eleonora Alterman, Leah Bar-Oz
  • Process for production of Bivalirudin
    Publication number: 20070093423
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: September 14, 2006
    Publication date: April 26, 2007
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • Methods for the production of peptide derivatives
    Publication number: 20060276626
    Abstract: The invention relates to methods for the preparation of peptides which are a C-terminal amide derivatives by a combination of solid-phase synthesis and post assembly solution phase synthesis. The peptides which are a C-terminal amide derivatives are further converted to peptide acetates. The invention also relates to pure peptide acetates and to protected peptide precursors.
    Type: Application
    Filed: May 2, 2006
    Publication date: December 7, 2006
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaovi, Eleonora Alterman, Leah Bar-Oz, Tehila Gadi