Patents by Inventor Leah C. Byrne

Leah C. Byrne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods of Treating Ocular Diseases
    Publication number: 20240091378
    Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
    Type: Application
    Filed: February 10, 2023
    Publication date: March 21, 2024
    Inventors: David V. Schaffer, Leah C. Byrne, Timothy P. Day, John G. Flannery
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
    Publication number: 20230321282
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: December 14, 2022
    Publication date: October 12, 2023
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • Adeno-associated virus virions with variant capsid and methods of use thereof
    Patent number: 11565000
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: January 31, 2023
    Assignees: The Regents of the University of California, The Trustees of the University of Pennsylvania
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • Adeno-associated virus virions with variant capsid and methods of use thereof
    Patent number: 11565001
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: January 31, 2023
    Assignees: The Regents of the University of California, The Trustees of the University of Pennsylvania
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • Adeno-associated virus virions with variant capsid and methods of use thereof
    Patent number: 11554180
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: January 17, 2023
    Assignees: The Regents of the University of California, The Trustees of the University of Pennsylvania
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
    Publication number: 20220362409
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: June 16, 2022
    Publication date: November 17, 2022
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
    Publication number: 20220331451
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: June 16, 2022
    Publication date: October 20, 2022
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
    Publication number: 20220331450
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: June 16, 2022
    Publication date: October 20, 2022
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
    Publication number: 20210283274
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: July 27, 2017
    Publication date: September 16, 2021
    Inventors: David V. Schaffer, John G. Flannery, William A. Beltran, Leah C. Byrne, Meike Visel
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSIDS AND METHODS OF USE THEREOF
    Publication number: 20200121746
    Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
    Type: Application
    Filed: June 28, 2018
    Publication date: April 23, 2020
    Inventors: David V. Schaffer, Leah C. Byrne, Timothy P. Day, John G. Flannery