Patents by Inventor Leah E. Appel

Leah E. Appel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF
    Publication number: 20230133629
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Application
    Filed: September 2, 2022
    Publication date: May 4, 2023
    Inventors: Leah E. APPEL, Joshua R. SHOCKEY, D. Christopher SCHELLING
  • Palatable compositions including sodium phenylbutyrate and uses thereof
    Patent number: 11433041
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: September 6, 2022
    Assignee: Acer Therapeutics Inc.
    Inventors: Leah E. Appel, Joshua R. Shockey, D. Christopher Schelling
  • Methods of treating urea cycle disorders and maple syrup urine disease
    Patent number: 11202767
    Abstract: The present invention provides methods for the treatment of urea cycle disorders and Maple Syrup Urine Disease.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: December 21, 2021
    Assignee: Acer Therapeutics Inc.
    Inventors: Leah E. Appel, Joshua R. Shockey, D. Christopher Schelling
  • Palatable compositions including sodium phenylbutyrate and uses thereof
    Patent number: 11154521
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: October 26, 2021
    Assignee: Acer Therapeutics Inc.
    Inventors: Leah E. Appel, Joshua R. Shockey, D. Christopher Schelling
  • Multiparticulates of spray-coated drug and polymer on a meltable core
    Patent number: 11116728
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: September 14, 2021
    Assignee: Bend Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • METHODS OF TREATING UREA CYCLE DISORDERS AND MAPLE SYRUP URINE DISEASE
    Publication number: 20210220304
    Abstract: The present invention provides methods for the treatment of urea cycle disorders and Maple Syrup Urine Disease.
    Type: Application
    Filed: March 9, 2021
    Publication date: July 22, 2021
    Inventors: Leah E. APPEL, Joshua R. SHOCKEY, D. Christopher SCHELLING
  • PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF
    Publication number: 20210186908
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Application
    Filed: March 9, 2021
    Publication date: June 24, 2021
    Inventors: Leah E. APPEL, Joshua R. SHOCKEY, D. Christopher SCHELLING
  • PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF
    Publication number: 20200261385
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Application
    Filed: January 17, 2020
    Publication date: August 20, 2020
    Inventors: Leah E. APPEL, Joshua R. SHOCKEY, D. Christopher SCHELLING
  • MULTIPARTICULATES OF SPRAY-COATED DRUG AND POLYMER ON A MELTABLE CORE
    Publication number: 20190307702
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Application
    Filed: June 13, 2019
    Publication date: October 10, 2019
    Applicant: Bend Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • Multiparticulates of spray-coated drug and polymer on a meltable core
    Patent number: 10357462
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: July 23, 2019
    Assignee: Ben Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF
    Publication number: 20170266115
    Abstract: The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
    Type: Application
    Filed: October 17, 2016
    Publication date: September 21, 2017
    Inventors: Leah E. APPEL, Joshua R. SHOCKEY, D. Christopher SCHELLING
  • Pharmaceutical dosage forms comprising a low-solubility drug and a polymer
    Patent number: 9445998
    Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 20, 2016
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, Walter C. Babcock, Dwayne T. Friesen, Roderick J. Ray, Daniel T. Smithey, Sheri L. Shamblin, Ravi M. Shanker
  • Immediate release dosage forms containing solid drug dispersions
    Patent number: 9211261
    Abstract: High loading immediate release dosage forms containing at least 30 wt % of a solid drug dispersion, at least 5 wt % of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 15, 2015
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, John E. Byers, Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Stephen J. Schadtle
  • Hydrogel-driven drug dosage form
    Patent number: 9028870
    Abstract: A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: May 12, 2015
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, Ronald A. Beyerinck, Mark B. Chidlaw, William J. Curatolo, Dwayne T. Friesen, Kelly L. Smith, Avinash G. Thombre
  • PHARMACEUTICAL DOSAGE FORMS COMPRISING A LOW-SOLUBILITY DRUG AND A POLYMER
    Publication number: 20150064264
    Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Applicant: Bend Research, Inc.
    Inventors: Leah E. Appel, Walter C. Babcock, Dwayne T. Friesen, Roderick J. Ray, Daniel T. Smithey, Sheri L. Shamblin, Ravi M. Shanker
  • HYDROGEL-DRIVEN DRUG DOSAGE FORM
    Publication number: 20110182947
    Abstract: A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
    Type: Application
    Filed: December 27, 2010
    Publication date: July 28, 2011
    Inventors: Leah E. Appel, Ronald A. Beyerinck, Mark B. Chidlaw, William J. Curatolo, Dwayne T. Friesen, Kelly L. Smith, Avinash G. Thombre
  • Method of making pharmaceutical multiparticulates
    Patent number: 7951403
    Abstract: A process for forming drug multiparticulates having improved drug crystallinity is disclosed, comprising modifying a conventional melt-congeal process by adding a volatile cospecies either to the molten mixture or to the process atmosphere, or to both.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 31, 2011
    Assignee: Pfizer Inc.
    Inventors: Dwayne T. Friesen, Marshall D. Crew, Roderick J. Ray, Leah E. Appel
  • Multiparticulate crystalline drug compositions having controlled release profiles
    Patent number: 7887844
    Abstract: A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: February 15, 2011
    Assignee: Pfizer Inc.
    Inventors: Leah E. Appel, Roderick J. Ray, David K. Lyon, James B. West, Scott B. McCray, Marshall D. Crew, Dwayne T. Friesen, Scott M. Herbig, Julian B. Lo
  • Multiparticulate compositions with improved stability
    Patent number: 7736672
    Abstract: A process is described for producing drug-containing multiparticulates with improved stability, characterized by an improvement in one or more of chemical stability, physical stability, or dissolution stability.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: June 15, 2010
    Assignee: Pfizer, Inc.
    Inventors: Roderick J. Ray, Leah E. Appel, Dwayne Thomas Friesen, Marshall D. Crew, Joshua R. Shockey
  • MULTIPARTICULATES OF SPRAY-COATED DRUG AND POLYMER ON A MELTABLE CORE
    Publication number: 20100068276
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Application
    Filed: November 19, 2007
    Publication date: March 18, 2010
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurhu, Edward Dennis LaChapelle