Patents by Inventor Leah E. COWEN

Leah E. COWEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungal modulators
    Patent number: 11773086
    Abstract: The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: October 3, 2023
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Lauren E. Brown, Kaddy Camara, Leah E. Cowen, John A. Porco, Jr., Kali Rae Iyer
  • Hsp90 inhibitors and uses thereof
    Patent number: 11312722
    Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: April 26, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, The Governing Council of the University of Toronto
    Inventors: Lauren Elaine Brown, David S Huang, Leah E. Cowen, Luke Whitesell, Paul Marcyk
  • NOVEL FUNGAL MODULATORS
    Publication number: 20220064152
    Abstract: The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 3, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Lauren E. BROWN, Kaddy CAMARA, Leah E. COWEN, John A. PORCO, JR.
  • HSP90 INHIBITORS AND USES THEREOF
    Publication number: 20200354373
    Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 12, 2020
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, The Governing Council of the University of Toronto
    Inventors: Lauren Elaine BROWN, David HUANG, Leah E. COWEN, Luke WHITESELL, Paul MARCYK