Abstract: A blockchain-based lending or loan processing platform is provided. The platform comprises: a blockchain onboarding system comprising a smart contract execution environment (CEE). The blockchain onboarding system is configured to: (1) automatically process loan data from a loan origination system (LOS) for virtual execution of one or more loan contracts within the CEE, and the loan data comprises a plurality of loan-related facts; (2) encrypt the loan-related facts to generate a plurality of encrypted facts associated with one or more loan assets; and (3) generate a plurality of hashes for the encrypted facts. The hashes are recorded on a blockchain, and the combinations of each encrypted fact with its corresponding hash are deposited in an encrypted object store (EOS) separate from the blockchain. The platform also comprises a digital asset registration tool (DART) to track substantially in realtime the control, transfers, assignments and/or ownership of controllable electronic records.

Abstract: Provided herein are methods and compositions for the treatment of ALS using chlorite or a pharmaceutical composition comprising sodium chlorite, for a target ALS patient population. Also provided herein are methods for identifying a target ALS patient population likely to be responsive to treatment with chlorite or a pharmaceutical composition comprising sodium chlorite, the methods including identifying ALS patients with elevated plasma C-reactive protein (CRP) levels and/or patients age 40-65, sporadic ALS pathology, or combinations thereof.